The invention discloses a natural astaxanthin-containing premix compound which comprises the following components according to weight ratio: 30-80g/kg of broken wall haematococcus pluvialis powder, 150-300g/kg of bean pulp, 150-200g/kg of calcium hydrophosphate, 150-250g/kg of mountain flour, 50-70g/kg of table salt, 0.6-0.9g/kg of nicotinic acid, 0.1-0.2g/kg of D-calcium pantothenate, 0.0016-0.0024g/kg of biotin, 7.5-12.5g/kg of choline chloride, 0.256-0.512g/kg of copper salt based on the content of copper, 1-2g/kg of ferric salt based on the content of ferrum, 1.2-2.4g/kg of zinc salt based on the content of zinc, 1.3-2.6g/kg of manganese salt based on the content of manganese, 0.02-0.04g/kg of iodate salt based on the content of iodate, 0.003-0.007g/kg of selenium salt based on the content of selenium, 20-35g/kg of methionine, 0.33-1.0g/kg of ethoxy quinoline, 1-3g/kg of phytase, 5-15g/kg of composite microecologics, 1-3g/kg of xylo-oligosaccharide and 80-120g/kg of bentonite. The natural astaxanthin-containing premix compound can remarkably improve the laying rate, reduce mortality and elimination rate, ensure proper colors of red-yolk eggs, promote the feed conversion rate, improve the production performance of laying hens and the eggshell quality, reduce the occurrence of diseases, and improve the economic efficiency.