Preparation method for decellularized periosteal matrix gel material sourced from natural tissue

An acellular bone and gel material technology, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of inability to obtain sufficient specific surface area, low retention of bioactive substances, and no periosteal ECM gel. Biological activity, promoting in situ regeneration, increasing the effect of repair function
CN110237303AActive Publication Date: 2019-09-17ZHEJIANG DISAI BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG DISAI BIOTECHNOLOGY CO LTD
Publication Date
2019-09-17

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Abstract

The invention discloses a preparation method for a decellularized periosteal matrix gel material sourced from natural tissue. By conducting freeze drying on decellularized periosteal matrix sourced from mammal, bioactive molecules are kept to the maximum degree; the decellularized periosteal matrix gel material sourced from natural tissue is ground into powder, the grain size of the powder is controlled, the contact area of a solution is increased, in this way, digestion is promoted, and finally the standard and uniform decellularized periosteal matrix gel having a good osteogenic activity potential is obtained. In addition, EDC crosslinking growth factors have a good promoting effect when regenerated bone tissue is regenerated excellently and grows into with vascularization. The decellularized periosteal matrix gel material can be used for repairing bone defects, bone disunion and other kinds of bone regeneration obstacles caused by all kinds of clinical pathogeneses.
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Description

technical field

[0001] The invention belongs to the technical field of bone tissue repair and regeneration, and in particular relates to a preparation method of an acellular periosteum matrix gel material derived from natural tissue. Background technique

[0002] Bone defect is a common clinical disease, which often causes bone nonunion, delayed union or nonunion, and local dysfunction, which causes pain to patients, restricts their mobility, and seriously affects their quality of life. Although traditional synthetic materials can provide sufficient mechanical support, they have poor biological activity, insufficient osteoinductivity, are not easy to degrade, and even cause foreign body reactions. At present, autologous bone grafting and allogeneic bone grafting are the main methods for treating bone defects and osteonecrosis. There is an urgent need to develop new bone tissue engineering materials with good bone healing and regenerative repair effects.

[0003] Extracellu...

Claims

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