7 results about "Bird flu" patented technology

The invention relates to the technical field of bird flu host species identification, in particular to a new bird flu high-risk host species identification method based on virus sharing entropy. According to the method, on the basis of spatial distribution prediction of bird flu host species, the bird flu virus sharing entropy of the bird flu host species is calculated species by species according to the overlapping areas of the target host species and all other host species by extracting the distribution area overlapping area of the target host species and any other host species, and the bird flu virus sharing entropy of the bird flu host species is obtained. And quantitatively analyzing the possibility that the target host species and other host species are subjected to avian influenza cross-species transmission infection. By comparing and analyzing the entropy value of the shared entropy of the avian influenza virus, the avian influenza host species with high virus reassortment risk are identified, and a scientific basis is provided for prevention and control of epidemic diseases.

The invention discloses a recombinant HVT for co-expressing an H9 subtype AIV HA gene, an IBV S gene and an IBDV VP2 gene and application of the recombinant HVT, and belongs to the technical field of medicine or veterinary medicine. The recombinant HVT is a recombinant HVT vaccine strain H30201 for co-expressing the H9 subtype AIV HA gene, the IBV S gene and the IBDV VP2 gene, which is obtained by inserting an expression cassette containing the H9 subtype AIV HA gene and the QX type IBV S gene between 95322-95323 nucleotides of an HVT FC126 strain and inserting an expression cassette containing the IBDV classic virulent strain VP2 gene between 112071-112088 nucleotides of an HVT genome at the same time through virus rescue. The invention also provides application of the recombinant HVT vaccine strain in preparation of vaccines for H9 subtype avian influenza, infectious bronchitis and infectious bursal disease.

The invention discloses an avian influenza space-time distribution characteristic sampling monitoring method and device, and relates to the field of avian influenza data processing, and the method comprises the steps: obtaining multi-source data of a research region; the multi-source data comprises an avian influenza outbreak data set, a land utilization data set, a vegetation index data set, a climate change data set, a population density data set and a topographic data set; performing time sequence analysis on the outbreak starting time according to months by using the avian influenza outbreak data set, counting the outbreak frequency per month, and determining the avian influenza outbreak time characteristics of the research area; performing avian influenza outbreak risk hot spot area and key factor identification according to the multi-source data by using a maximum entropy model to obtain avian influenza outbreak space distribution characteristics of the research area; the bird flu outbreak time characteristic and the bird flu outbreak space distribution characteristic form a bird flu space-time distribution characteristic, and the bird flu outbreak time characteristic and the bird flu outbreak space distribution characteristic aim at overcoming the defects in the existing monitoring technology and providing scientific basis and technical support for bird flu prevention and control.

The application provides an intelligent analysis platform for risk assessment of wild bird flu virus recombination, relates to the technical field of influenza virus monitoring and risk assessment, and comprises a multi-source monitoring data acquisition module, a data preprocessing module, a virus sequence intelligent analysis module, a recombination risk assessment module, a spatial situation analysis and visualization module and a report generation and early warning module connected in sequence through an API interface. The intelligent analysis platform for risk assessment of wild bird flu virus recombination can realize multi-source monitoring data acquisition, virus sequence intelligent analysis, recombination risk quantitative assessment and spatial visualization early warning, and provides whole-process technical support for influenza virus recombination prevention and control.

The present invention relates to an environmentally friendly epidemic prevention composition that has the function of killing phospholipid enveloped viruses, and contains 10-40% by weight of polyoxyethylene lauryl ether, 0.01-10% by weight of polyoxyethylene 2-ethylhexyl ether, 0.01-10% by weight of polyoxyethylene polyoxypropylene alkyl ether, and the remaining amount of solvent, based on a total of 100% by weight. The environmentally friendly epidemic prevention composition according to the present invention has a 100% SARS-CoV-2 virus removal rate in 1 minute, an effect of killing 100% highly pathogenic avian influenza viruses in 1 to 10 minutes, and an IC20 value of 100% for human epithelial keratinocyte cells (HaCaT), human bronchial epithelial cells (BEAS-2B), and human monocyte cells (THP-1) is 100%. 50 The value (%) is in the range of 0.003 to 0.0045, indicating that the compound has low cytotoxicity and antibacterial activity against both non-pathogenic and pathogenic strains.

The invention provides a recombinant herpesvirus turkey for co-expressing a supervirulent strain of an infectious bursal disease virus, a novel variant VP2 gene and an H9 subtype avian influenza virus HA gene as well as a construction method and application of the recombinant herpesvirus turkey. The method comprises the following steps: inserting an expression framework containing a chicken infectious bursal disease virus novel variant VP2 gene and an H9 subtype avian influenza virus HA gene between 95322-95323 nucleotides of a turkey herpesvirus genome; meanwhile, a chicken infectious bursal disease virus super virulent strain VP2 gene expression framework is inserted between the 112071-112088 site nucleotides of a turkey herpesvirus genome, and a recombinant turkey herpesvirus vaccine strain H20401 which co-expresses the chicken infectious bursal disease virus super virulent strain, the novel variant VP2 gene and the H9 subtype avian influenza virus HA gene is obtained through rescue. The vaccine prepared from the recombinant turkey herpesvirus provided by the invention can provide multiple protection against a chicken infectious bursal disease virus supervirulent strain, a novel variant and an avian influenza virus, and has a good market application prospect.

The invention discloses a recombinant herpesvirus turkey strain for expressing an H9 subtype AIV HA gene and an IBV S gene and application of the recombinant herpesvirus turkey strain, and belongs to the technical field of medicine or veterinary medicine. The recombinant turkey herpesvirus strain is obtained by inserting an expression framework containing a chicken beta actin promoter, an AIV HA gene and IBV S gene coding sequence, a posttranscriptional regulatory sequence of a dial rat hepatitis virus and a rabbit beta globulin polyadenylic acid sequence into an HVT genome. The recombinant virus strain obtained by the invention has good in-vitro replication ability and genetic stability. After SPF chickens are immunized, the SPF chickens can obtain immune protection on H9 subtype AIV (avian influenza virus) and QX type IBV (infectious bursal virus). The invention provides a new technical means for simultaneously preventing the H9 subtype avian influenza and the avian infectious bronchitis.