Daimeton (sodium) suspension injection and preparation thereof

A technology of sulfamethoxine and sodium methotrexate, which is applied in the field of suspensions, can solve the problems of short half-life, strong irritation, and inconvenient administration of animals, and achieve improved curative effect, improved production performance, and improved bioavailability degree of effect

Inactive Publication Date: 2008-12-17
CHONGQING FANGTONG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pH value of sulfamethoxine sodium injection is 9.5-11.0, the administration route is intravenous injection, and the administration frequency is 1-2 times a day for 2-3 consecutive days. Therefore, there are strong irritation, Disadvantages such as inconvenient administration and short half-life to animals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] ①20% Sulfamethoxine Suspension Injection

[0023] A kind of sulfamethoxine suspension injection, its full prescription is:

[0024] Sulfamethoxine 200g

[0025] Aluminum stearate 3g

[0026] Oily vehicle up to 1000ml

[0027] The preparation method of described sulfamethoxine suspension injection is carried out as follows:

[0028] Take 1000ml of oily medium, sterilize at 150°C for 1h, cool to below 60-80°C, and set aside; take 3g of aluminum stearate, soak in 500ml of sterilized oily medium, heat to 120°C, keep for 1h, stir to make stearin Acid aluminum oil gel, cooled to below 50°C; add the prescribed amount of sulfamethoxine, stir evenly, put it in a colloid mill and grind for 30 minutes, add sterilized oily solvent to the full amount, mix evenly, filter with a 200-mesh silk sieve, and While stirring, it was divided into ground glass bottles, covered with rubber stoppers, crimped caps, and sterilized by autoclaving at 121°C for 20 minutes.

[0029] ②20% Sulfamet...

Embodiment 2

[0037] ①1% Sulfamethoxine Suspension Injection

[0038] A kind of sulfamethoxine suspension injection, its full prescription is:

[0039] Sulfamethoxine 10g

[0040] Aluminum stearate 3g

[0041] Oily vehicle up to 1000ml

[0042] The preparation method of described sulfamethoxine suspension injection is carried out by the preparation method described in Example 1.

[0043] ②1% Sulfamethoxine Sodium Suspension Injection

[0044] A kind of sulfamethoxine sodium suspension injection, its complete prescription is:

[0045] Sulfamethoxine Sodium 10g

[0046] Aluminum stearate 3g

[0047] Oily vehicle up to 1000ml

[0048] The preparation method of described sulfamethoxine sodium suspension injection is carried out by the preparation method described in Example 1.

Embodiment 3

[0050] ①50% Sulfamethoxine Suspension Injection

[0051] A kind of sulfamethoxine suspension injection, its full prescription is:

[0052] Sulfamethoxine 500g

[0053] Aluminum stearate 3g

[0054] Oily vehicle up to 1000ml

[0055] The preparation method of described sulfamethoxine suspension injection is carried out by the preparation method described in Example 1.

[0056] ②50% Sulfamethoxine Sodium Suspension Injection

[0057]A kind of sulfamethoxine sodium suspension injection, its complete prescription is:

[0058] Sulfamethoxine Sodium 500g

[0059] Aluminum stearate 3g

[0060] Oily vehicle up to 1000ml

[0061] The preparation method of described sulfamethoxine sodium suspension injection is carried out by the preparation method described in Example 1.

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PUM

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Abstract

The invention relates to a new veterinary medicine preparation (sulfamonomethoxine suspension injection or sulfamonomethoxine sodium suspension injection) and a preparation method thereof; the new veterinary medicine preparation is prepared by taking sulfamonomethoxine or sulfamonomethoxine sodium as main drug and other excipients for assist. The percentage of the main ingredients in the suspension is as follows: 1%-50% (W / V) of sulfamonomethoxine or sulfamonomethoxine sodium and the rest of drug excipients; the excipients include a suspending agent and a disperse medium. The invention takes oil solvent as the disperse medium to prepare sulfamonomethoxine or sulfamonomethoxine sodium into a long-acting and sustained-release preparation; by adopting intramuscular injection for drug administration, the in vivo acting time of the drug can be significantly prolonged, the times of drug administration are reduced and the blood concentration of diseased livestock can keep stable. The new veterinary medicine preparation of the invention is safe, stable, effective and controllable in quality, thus being widely applicable to the treatment of bacterial infection and parasitic infestation in livestock.

Description

technical field [0001] The invention relates to a suspension used for treating diseases in animals, in particular to a sulfamethoxine suspension injection, a sulfamethoxine sodium suspension injection and a preparation method thereof. Background technique [0002] Sulfamethoxine is one of the sulfonamides with the strongest antibacterial effect in vivo and in vitro. The acetylated compound of this product has high solubility in urine and low toxicity, and has a good effect on the prevention and treatment of bacterial infections in livestock and poultry. In addition, it has a significant preventive effect on coccidiosis and toxoplasmosis in animals. In my country, it was first recorded in the Pharmacopoeia of the People's Republic of China (1985 edition, 1990 edition), and later recorded in the "People's Republic of China Veterinary Pharmacopoeia" (1990 edition, 2000 edition, 2005 edition). Methoxypyrimidine sodium salt and its preparations. In foreign countries, it was reco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/635A61K47/12A61K47/44A61P31/04A61P33/02
Inventor 吴俊伟
Owner CHONGQING FANGTONG ANIMAL PHARMA
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