A kind of fushenone hydrobromide soluble powder and preparation method thereof

A halofuginone hydrobromide, soluble technology, applied in powder delivery, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of high packaging and transportation costs, difficulty in halofuginone hydrobromide, and inability to drink from poultry, etc., and achieves improvement. Hydrophilicity, good water solubility, and the effect of solving clinical drinking water administration problems

Active Publication Date: 2022-02-08
HENAN SOAR VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hydrogenone hydrobromide is difficult to dissolve in water. Most of the products currently on the market are hydrobromide premixes, which cannot be used for poultry drinking, but can only be used for mixing, which greatly limits clinical application.
CN201611053242.2 discloses a haloethanone hydrobromide solution and a preparation method thereof, which dissolves haloethanone hydrobromide into a liquid dosage form through an organic solvent, but this invention contains a large amount of organic solvents, which are harmful to animal bodies Potential hazards, plus high packaging and shipping costs for liquid dosage forms

Method used

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  • A kind of fushenone hydrobromide soluble powder and preparation method thereof
  • A kind of fushenone hydrobromide soluble powder and preparation method thereof
  • A kind of fushenone hydrobromide soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription of Huoshanone Hydrobromide Soluble Powder:

[0025] Hemosanone hydrobromide 0.6 g;

[0026] Self-emulsifying monoglyceride A165 2.0 g;

[0027] Triethylene glycol 20.0 g;

[0028] Beta-cyclodextrin 77.4 g.

[0029] The preparation method of fusanone hydrobromide soluble powder:

[0030] (1) According to the above prescription, measure fushenone hydrobromide, self-emulsifying monoglyceride A165, triethylene glycol, and β-cyclodextrin; Add the alcohol into the reaction tank, keep the temperature at 70°C, stir and emulsify for 30 minutes, mix evenly and pass through the colloid mill, the gap between the stator and the rotor is 25 μm, grind for 3 times, and obtain the peroxide hydrobromide self-emulsifying concentrate ;

[0031] (2) Pulverize the above-mentioned β-cyclodextrin, pass through a 100-mesh sieve, and then mix evenly with the self-emulsifying concentrate obtained in step (1) to obtain a semi-solid;

[0032] (3) Dry the semi-solid obtained in st...

Embodiment 2

[0034] Prescription of Huoshanone Hydrobromide Soluble Powder:

[0035] Hemosanone hydrobromide 2.0 g;

[0036] Polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer 20.0g;

[0037] Diethylene glycol monoethyl ether 1.0 g;

[0038] Mannitol 77.0 g.

[0039] The preparation method of fusanone hydrobromide soluble powder:

[0040] (1), according to the above-mentioned prescription measure hiradhenone hydrobromide, polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, diethylene glycol monoethyl ether, mannitol; Add ketone, polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and diethylene glycol monoethyl ether into the reaction tank, keep the temperature at 50 °C, stir and emulsify for 30 min, mix well and pass through the colloid mill , the size of the gap between the stator and the rotor is 25 μm, grinding 3 times to obtain the hydrogen bromide self-emulsifying concentrate;

[0041] (2) Pulveri...

Embodiment 3

[0044] Prescription of Huoshanone Hydrobromide Soluble Powder:

[0045] Hemosanone hydrobromide 1.5 g;

[0046] Macrogol glyceride laurate 6.5 g;

[0047] Glycerol formal 2.0 g;

[0048] Water-soluble starch 90.0 g.

[0049] The preparation method of fusanone hydrobromide soluble powder:

[0050] (1) According to the above prescription, measure fushenone hydrobromide, macrogolglycerol laurate, glycerin formal, and water-soluble starch; Add formaldehyde into the reaction tank, hold the temperature at 40 ℃, stir and emulsify for 30 minutes, mix evenly and pass through the colloid mill, the gap between the stator and the rotor is 25 μm, and grind 3 times to obtain the self-emulsifying concentrated solution of peroxide hydrobromide ;

[0051] (2) Pulverize the above-mentioned water-soluble starch, pass through a 100-mesh sieve, and then mix evenly with the self-emulsifying concentrate obtained in step (1) to obtain a semi-solid;

[0052] (3) Dry the semi-solid obtained in st...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and discloses a soluble hiruzenone hydrobromide powder and a preparation method thereof. It is made of the following raw materials in weight percent: 0.6-2% hemosanone hydrobromide, 2.0-30.0% emulsifier, 1.0-20.0% co-emulsifier, and 50.0-90.0% soluble solid adsorption material. Preparation method: Mix hiruzenone hydrobromide, emulsifier and co-emulsifier uniformly at 40-70°C, pass through colloid mill treatment, and cool to room temperature to obtain hiradhenone hydrobromide self-emulsifying concentrate; water-soluble solid After the adsorption material is pulverized, it is uniformly mixed with the hydrobromide self-emulsifying concentrate to obtain a semi-solid; the semi-solid is dried and pulverized to obtain a hydrobromide soluble powder. The hydrobromide soluble powder prepared by the present invention has water solubility, not only solves the problem of clinical drinking water administration, but also has advantages and is more convenient than the liquid hydrobromide solution in terms of packaging, carrying, and transportation. It has a good application prospect for treating coccidiosis.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a soluble hiruzenone hydrobromide powder and a preparation method thereof. Background technique [0002] Changshanone has two isomers, cis and trans, and the trans is the active ingredient. The anti-coccidiostat activity of trans Changshanone is 25 times higher than that of cis, which may be related to the cis Changshan The hydroxyl group on the piperidine group in the ketone is related to the ketone group replaced by the quinazolinone to form a hemiketal. This product is an anticoccidial drug with a small dosage, and has a wide anticoccidial spectrum, and is effective against various coccidia in chickens; it is also effective against Eimeria minor and Eimeria glandularis in turkeys Strong effect; it can inhibit the early reproductive spores of coccidia and the first and second generation schizonts, and can control the discharge of oocysts, reduci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/517A61K47/14A61K47/10A61P33/02A61K9/107
CPCA61K9/145A61K9/146A61K31/517A61P33/02A61K9/107
Inventor 胡帅罗显阳李凌峰赵硕磊郝小倩高贵超崔俊亚
Owner HENAN SOAR VETERINARY PHARMA
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