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A kind of fluoroquinolone antibiotic capsule for pet and preparation method thereof

A fluoroquinolone and antibiotic technology, which is applied in the field of pet fluoroquinolone antibiotic capsules and its preparation, can solve the problems of inability to achieve enteric coating effect, and achieve convenient clinical administration, good stability, and improved bioavailability. Effect

Active Publication Date: 2022-08-05
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Chinese patent CN109464482A discloses compound enrofloxacin enteric-coated capsules and a preparation method for preventing and treating yellow and white scours of piglets. The enteric-coating materials described in this patent include ethyl cellulose and polyethylene glycol, which are all water-soluble When the capsule passes through the digestive tract and stomach, the capsule shell has been dissolved by the digestive juice, while ethyl cellulose and polyethylene glycol cannot protect the drug from being released in the gastric juice, so this patent cannot be used clinically It achieves the effect of enteric coating and is only suitable for pigs

Method used

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  • A kind of fluoroquinolone antibiotic capsule for pet and preparation method thereof
  • A kind of fluoroquinolone antibiotic capsule for pet and preparation method thereof
  • A kind of fluoroquinolone antibiotic capsule for pet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0031] Embodiment 1-6 Fluoroquinolone antibiotic capsule specific prescription and dosage

[0032]

Embodiment 1～6

[0033] The preparation method of embodiment 1~6 is as follows:

[0034] (1) Handling and weighing of raw and auxiliary materials: Pass the raw materials and all auxiliary materials through an 80-mesh sieve respectively for use; weigh all raw materials and auxiliary materials according to the prescribed amount and mark them well.

[0035] (2) Preparation of coating liquid: soak the coating powder in 95% ethanol for 24 hours overnight, add stabilizer and stir for at least 10 hours, add lubricant and keep stirring before use.

[0036] (3) Granulation and drying: the fluoroquinolone raw materials and the filler are double-diluted, and after passing through an 80-mesh sieve three times, a 20% aqueous binder solution is added for mixing, and the granulation and spheronization are carried out with an extrusion spheronizer. and dried at 50°C for 2 hours.

[0037] (4) Fluidized bed coating: the atomization pressure is 1.5 to 3.0 bar, the spray rate is 5 to 15 g / min, the inlet air temp...

Embodiment 7

[0042] Example 7 In vitro simulated intestinal release test

[0043] Determination method of release rate: According to the second method of release rate determination method in the appendix of "Veterinary Pharmacopoeia of the People's Republic of China" 2015 edition, high performance liquid chromatography was used for sample injection measurement, and the release rate of the capsule preparation prepared in the Example was determined.

[0044] Test material: prepare the enteric-coated capsule preparation of prafloxacin according to the method in Example 4, commercially available ciprofloxacin capsules for human use in 0.25g specifications, Comparative Example 1, Comparative Example 2 (blank capsules are used for each sample) shell for dispensing to meet the testing amount required by the Veterinary Pharmacopoeia).

[0045] test results:

[0046] Dissolution testing of capsule preparations

[0047] preparation Dissolution % in acid Dissolution % in Alkali Ex...

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Abstract

The invention relates to a fluoroquinolone antibiotic capsule for pets and a preparation method thereof, belonging to the technical field of pet medicine. The capsules of the present invention are composed of capsule contents and capsule shells. The content of the capsule includes a pill core and a coating liquid, wherein the components in the pill core and their weight percentages are: 60.0-90.0% of fluoroquinolone antibiotics, 1.0-5.0% of adhesive, 5.0-39.0% of filler, The weight percent composition of the coating liquid is: coating powder 97.0-99.8%, lubricant 0.1-2.0%, stabilizer 0.1-2.0%. The invention is mainly applied to the prevention and treatment of gram-positive bacteria, negative bacteria, mycoplasma and mycoplasma in pet dogs and cats, and has the advantages of broad-spectrum sterilization, good palatability, rapid action, remarkable curative effect, convenient use and the like.

Description

technical field [0001] The invention belongs to the technical field of pet medicine, in particular to a fluoroquinolone antibiotic capsule for pets and a preparation method thereof. Background technique [0002] The number of pets is very large. According to professional statistics in 2010, 63% of households in the United States (about 71,100 households) have pets, including about 50 million dogs, 60 million cats, and 45 million poultry. , 75 million other small mammals and reptiles and tens of millions of fish; 62 million households in Europe have pets, 60 million cats, 27 million dogs and 35 million birds ; In my country, there are about 150 million pet dogs and 30-50 million cats. [0003] Pet skin diseases account for about 30% of clinical cases. Although skin diseases generally do not lead to death, the treatment cycle is long and prone to recurrence, and some cases, especially intractable skin diseases, cannot be cured for a long time. Staphylococcus infection is a ver...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/62A61K47/32A61K47/26A61K47/38A61K45/00A61K31/4709A61P31/04
CPCA61K9/5042A61K45/00A61K31/4709A61P31/04
Inventor 李梁刘爱玲李守军李亚玲吴燕子王娟张朋丽
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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