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Gastric retention long acting preparation and preparation method thereof

A gastric retention and long-acting technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pill delivery, etc. It can solve problems such as short retention time, complicated production process, and uneven drug release. , to achieve the effect of easy control of the production process, stable and reliable quality, and suitable for large-scale batch production

Pending Publication Date: 2020-01-31
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] One of the objectives of the present invention is to provide a long-acting gastric retention preparation to solve the problems of short retention time, inability to release the drug uniformly, and complicated production process of the existing gastric retention long-acting drug preparations.

Method used

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  • Gastric retention long acting preparation and preparation method thereof
  • Gastric retention long acting preparation and preparation method thereof
  • Gastric retention long acting preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh 4mg of huperzine A and 1.5g of hydroxypropylmethylcellulose K100M, take 0.5ml of 75% ethanol to dissolve huperzine A, pour it into K100M evenly, and mix well to obtain a soft material; use a special mold to press Become the sustained-release drug microtablet of diameter 1.9mm, dry for subsequent use.

[0036] Take a medical sterile silicone tube with a length of 9cm (the inner diameter of the longitudinal section is 2mm, the outer diameter is 3mm), and one side of the tube wall is opened with a hole diameter of 0.5mm, and holes are evenly opened between the 0.5cm to 8.5cm section of the silicone tube 7 pieces; the 0.5cm to 8.5cm section of the open-hole silicone tube is filled with sustained-release drug microchips, and the space 0.5cm away from both ends is sealed by filling the silicone rubber special adhesive; the silicone section is sutured and sealed with degradable sutures, A closed drug-containing silicone ring is formed, and the silicone ring is folded and...

Embodiment 2

[0038]According to the method of Example 1, a long-acting gastric retention preparation containing 4 mg of huperzine A was prepared, and the resulting gastric retention long-acting preparation was put into a glass bottle, 10 ml of water was added, the bottle stopper was sealed, and 6 groups were parallelized. Put it into a shaking table, the rotating speed of the shaking table is 75r / min, measure the absorbance value by ultraviolet light every day, then change the water 10ml, continue to put it into the shaking table, and measure for 15 days. Record daily measurement data, calculate the average value, draw daily release and cumulative release curves, the results are as follows image 3 shown.

Embodiment 3

[0040] Weigh 4mg of huperzine A and 1.5g of hydroxypropyl methylcellulose K100M, take 0.5ml of 75% ethanol to dissolve huperzine A, pour it into K100M evenly, and mix well to obtain a soft material; use a special mold Press into sustained-release drug microtablets with a diameter of 1.9 mm, and dry for subsequent use.

[0041] Take a medical sterile silicone tube with a length of 9cm (the inner diameter of the longitudinal section is 2mm, the outer diameter is 3mm), and one side of the tube wall is opened with a hole diameter of 0.5mm, and holes are evenly opened between the 0.5cm to 8.5cm section of the silicone tube 9 pieces; the 0.5cm to 8.5cm section of the open-hole silicone tube is filled with sustained-release drug microchips, and the space 0.5cm away from both ends is sealed by filling the silicone rubber special adhesive; the silicone section is sutured and sealed with degradable sutures, A closed drug-containing silicone ring is formed, and the silicone ring is folde...

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Abstract

The invention provides a gastric retention long acting preparation and a preparation method thereof. The gastric retention long acting preparation comprises a gastric coated capsule shell and a medicine release unit, wherein the medicine release unit is folded into a geometric shape to be arranged in the gastric coated capsule shell and comprises a capillary member and a biology biodegradable connecting fitting, two ends of the capillary member are closed and one or more medicine release holes are formed in the wall of a pipe, and medicines are placed in the medicine release holes; and the biology biodegradable connecting fitting is used for enabling two ends of the capillary member to be connected. The preparation method is simple, the gastric retention long acting preparation is smooth in medicine release rate, and the medicine release holes of different numbers and different diameters are formed in the capillary member to regulate the medicine release rate and the medicine release time. The degradation time of the biology biodegradable connecting fitting is used for controlling the residence time of the preparation in the gaster.

Description

technical field [0001] The invention relates to an oral slow-controlled release preparation, in particular to a gastric retention long-acting preparation and a preparation method thereof. Background technique [0002] Oral sustained-release preparations can maintain the effective blood concentration of the drug within 12-24 hours, which to a certain extent makes up for the strong first-pass effect, inaccurate positioning, high fluctuation of blood drug concentration, and poor patient tolerance of traditional oral preparations. Insufficient, improve the bioavailability of the drug. However, due to the interference of factors such as gastric emptying, gastric motility, and gastric contents, most oral preparations are incompletely absorbed in the gastrointestinal tract and have low bioavailability. [0003] The research and development of gastric retention drug preparations provides a more effective drug delivery route for the treatment of gastrointestinal diseases, and also p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/24A61K9/44A61K47/38A61K31/4748
CPCA61K9/0065A61K9/4808A61K9/4866A61K31/4748
Inventor 胡连栋
Owner HEBEI UNIVERSITY
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