Enrofloxacin nano emulsion and method for preparing same

A technology of enrofloxacin and nanoemulsion, which is applied in the directions of emulsion delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve the problem of increasing the labor volume of intensive farms, increasing the cost of feeding and management, and the stress of animal injection. Large-scale problems such as large-scale industrial production, convenient clinical administration, and high drug concentration are achieved.

Inactive Publication Date: 2010-06-23
HENAN INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because enrofloxacin itself has the disadvantages of poor solubility in water, bitter taste, and poor palatability, its use and curative effect in animal oral administration are greatly affected, such as powder
The injection in its conventional dosage form has a short time of action in the body, and it needs to be repeatedly administered when used, which causes great injection stress to animals, and is time-consuming and troublesome, which increases the labor of intensive farms; although the suspension dosage form is administered The number of times is less than that of the injection type, but it also has the disadvantages of strong stress stimulation to individual animals during injection administration, which is not conducive to group administration and increases the cost of feeding and management

Method used

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  • Enrofloxacin nano emulsion and method for preparing same
  • Enrofloxacin nano emulsion and method for preparing same
  • Enrofloxacin nano emulsion and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Weigh 16.0g of enrofloxacin bulk drug, 30.0g of castor oil polyoxyethylene ether (EL-40), 3.3g of isopropyl myristate (IPM) and 20.0g of acetic acid, 34.8g of distilled water, and set aside ;

[0023] (2) dissolving the enrofloxacin crude drug of the prescribed amount in acetic acid, and adding castor oil polyoxyethylene ether (EL-40) and isopropyl myristate (IPM) of the prescribed amount, mixing for subsequent use;

[0024] (3) the distilled water of recipe quantity is used as water phase;

[0025] (4) At room temperature, slowly add the above-mentioned distilled water into the system while continuously stirring until a clear and transparent liquid is formed, that is, an enrofloxacin nanoemulsion with a particle size of 10-100 nm and a clear and uniform appearance is obtained.

Embodiment 2

[0027] (1) Weigh 0.1g of enrofloxacin bulk drug, 28.0g of polyoxyethylene ether hydrogenated castor oil (RH 40), 5.0g of ethyl acetate, 5.0g of propionic acid, and 51.0g of distilled water, and set aside;

[0028] (2) dissolving the enrofloxacin crude drug of the prescribed amount in propionic acid, and adding polyoxyethylene ether hydrogenated castor oil (RH 40) and ethyl acetate, mixing for subsequent use;

[0029] (3) the distilled water of recipe quantity is used as water phase;

[0030] (4) At room temperature, slowly add the above-mentioned distilled water into the system while continuously stirring until a clear and transparent liquid is formed, that is, an enrofloxacin nanoemulsion with a particle size of 10-100 nm and a clear and uniform appearance is obtained.

Embodiment 3

[0032] (1) Weigh 5.0 g of enrofloxacin bulk drug, 32.0 g of Tween-80, 1.6 g of isopropyl myristate (IPM), 21.5 g of lactic acid and 33.0 g of distilled water, and set aside;

[0033] (2) Dissolve the enrofloxacin bulk drug in the prescribed amount in lactic acid, add Tween-80 and isopropyl myristate (IPM), mix well and set aside;

[0034] (3) the distilled water of recipe quantity is used as water phase;

[0035] (4) At room temperature, slowly add the above-mentioned distilled water into the system while continuously stirring until a clear and transparent liquid is formed, that is, an enrofloxacin nanoemulsion with a particle size of 10-100 nm and a clear and uniform appearance is obtained.

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Abstract

The invention provides enrofloxacin nano emulsion and a method for preparing the same and relates to a veterinary medicine preparation. The invention aims to provide the enrofloxacin nano emulsion which has the advantages of good solubility and palatability, strong medicinal effect and long medicament acting time and a method for preparing the same. The enrofloxacin nano emulsion is prepared from the following raw materials in part by weight: 0.1 to 16.0 parts of enrofloxacin medicinal materials, 28.0 to 32.0 parts of surface active agent, 0.2 to 21.5 parts of auxiliary surface active agent, 1.6 to 5.0 parts of oil, and 33.0 to 54.0 parts of distilled water. The enrofloxacin nano emulsion has the advantages of simple preparation method, low production cost and easy mass industrialized production.

Description

Technical field: [0001] The invention relates to veterinary drug preparations, in particular to an enrofloxacin nanoemulsion and a preparation method thereof. Background technique: [0002] Enrofloxacin is a third-generation quinolone antibacterial drug specially used for animals. It not only has good antibacterial effects on bacteria in the stationary phase and growth phase, but also has a broad antibacterial spectrum, strong bactericidal activity, wide distribution in the body, and high tissue concentration. Other antibacterial drugs have no cross-resistance, less toxic and side effects, etc., so they are widely used in veterinary clinics, mainly for the treatment of bacterial infectious diseases and mycoplasma infections in animals. [0003] At present, the common dosage forms of enrofloxacin mainly include powder, injection and suspension. Because enrofloxacin itself has the disadvantages of poor solubility in water, bitter taste and poor palatability, its use and curat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/496A61K47/34A61K47/44A61P31/04A61K47/14A61K47/26
Inventor 杨雪峰赵恒章王自良张晓建杨理张慧辉
Owner HENAN INST OF SCI & TECH
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