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Sulfamonomethoxine (sodium) mixed suspension injection and preparation method thereof

A technology of sulfa-metamethoxine and sodium methoxine, which is applied in the field of suspensions, can solve the problems of short half-life of animals, strong irritation, and inconvenient rural medicines, so as to improve curative effect, improve production performance, and reduce drug administration The effect of times

Inactive Publication Date: 2014-06-11
QINGDAO BOITE BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pH value of sulfamethoxine sodium injection is 9.5-11.0. The administration route is intravenous injection, and the administration frequency is 1-2 times a day for 2-3 consecutive days. Disadvantages such as inconvenient medicine and short half-life to animals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] ①20% Sulfamethoxine Suspension Injection

[0029] A kind of sulfamethoxine suspension injection, its complete prescription is:

[0030] Sulfamethoxazole 200g

[0031] Aluminum stearate 3g

[0032] Oily vehicle to 1000mI

[0033] The preparation method of described sulfa-methoxyamylophilic suspension injection, carries out as follows:

[0034] Take 1000ml of oily solvent, sterilize at 150°C for 1h, cool to below 60-80°C, and set aside; take 3g of aluminum stearate, soak in 500ml of sterilized oily solvent, heat to 120°C, keep for 1h, stir to make stearin Acid aluminum oil gel, cooled to below 50°C; add the prescribed amount of sulfamethoxine, stir evenly, put it in a colloid mill and grind for 30 minutes, add sterilized oily solvent to

[0035] The whole amount, mixed evenly, filtered through a 200-mesh silk sieve, distributed into ground glass bottles while stirring, covered with rubber stoppers, rolled caps, and sterilized by autoclaving at 121°C for 20 minut...

Embodiment 2

[0045] ①20% Sulfamethoxine Suspension Injection

[0046] A kind of sulfamethoxine suspension injection, its complete prescription is:

[0047] Sulfamethoxine l0g

[0048] Aluminum stearate 3g

[0049] Oily vehicle up to 1000ml

[0050] The preparation method of described sulfamethoxine suspension injection is carried out by the preparation method described in Example 1.

[0051] ②20% Sulfamethoxine Sodium Suspension Injection

[0052] A kind of sulfamethoxine suspension injection, its complete prescription is:

[0053] Sodium sulfamethoxate l0g

[0054] Aluminum stearate 3g

[0055] Oily solvent up to 1000m1

[0056] The preparation method of described sulfamethoxine sodium suspension injection is carried out by the preparation method described in Example 1.

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Abstract

The invention relates to a novel veterinary preparation, namely sulfamonomethoxine suspension injection or sulfamonomethoxine sodium suspension injection, and a preparation method thereof. The preparation is prepared by using sulfamonomethoxine or sulfamonomethoxine sodium as a main drug and other auxiliary materials. The suspension injection comprises 1-45 percent (W / V) of the main component sulfamonomethoxine or sulfamonomethoxine sodium and medicinal auxiliary materials, wherein the auxiliary materials comprise a suspending agent, dispersion medium and an antioxidant. According to the preparation method, a long-acting sustained-release preparation is prepared from sulfamonomethoxine or sulfamonomethoxine sodium by using an oily solvent as a dispersion medium, is administrated in an intramuscular injection mode, can be used for remarkably prolonging the time of drug action in a body and reducing the number of administration times, and provides a stable plasma concentration to ill livestock. The suspension injection is safe, stable, effective and controllable in quality, and can be widely applied to livestock bacterial infection and parasitic infection.

Description

technical field [0001] The invention relates to a suspension used for treating diseases in animals, in particular to a sulfamethoxine suspension injection, a sulfamethoxine sodium suspension injection and a preparation method thereof. Background technique [0002] Sulfamethoxine is one of the sulfonamides with the strongest antibacterial effect in vivo and in vitro. The acetylated compound of this product has high solubility in urine and low toxicity, and has a good effect on the prevention and treatment of bacterial infections in livestock and poultry. In addition, it has a significant preventive effect on coccidiosis and toxoplasmosis in animals. my country first recorded in "Pharmacopia of the People's Republic of China" (1985 edition, 1990 edition), and later in "China Pharmacopoeia" [0003] Veterinary Pharmacopoeia of the People's Republic of China (1990 edition, 2000 edition, 2005 edition) recorded sulfamethoxine, sulfamethoxine sodium salt and its preparations. I...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/635A61P31/04
Inventor 郝智慧丁兆朋杨芬芳
Owner QINGDAO BOITE BIOPHARM
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