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Application of formononetin in cryptococcus neoformans

A technology of formononetin and Cryptococcus neoformans, applied in antifungal agents, medical preparations containing active ingredients, organic active ingredients, etc., to achieve good antifungal activity and broad antifungal spectrum

Inactive Publication Date: 2014-02-12
苏州市马尔泰新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report about the application of formononetin in infectious diseases

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  • Application of formononetin in cryptococcus neoformans
  • Application of formononetin in cryptococcus neoformans

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Embodiment 1

[0011] The specific implementation manners provided by the present invention will be described in detail below.

[0012] (1) Experimental method: conventional in vitro antibacterial test method (see: Antimicrob Agents Chemother 1995,39(5):1169 for details)

[0013] 1. Materials and Methods

[0014] (1) The compound to be tested in the present invention: formononetin, also known as formononetin (7-hydroxy-4'-methoxy isoflavone), its molecular formula is C 16 h 12 o 4 , the molecular weight is 268.26.

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Abstract

The invention relates to application of formononetin in cryptococcus neoformans. The technical scheme of the invention is the application of formononetin in preparing medicaments for treating antifungal infected diseases, wherein the fungus is cryptococcus neoformans. The compound has an excellent antifungal activity on various superficial and deep funguses, has the advantages of high activity, low toxicity, broad antifungal spectrum and the like when being compared with an antifungal medicament in existing clinical application, and can be used for preparing antifungal medicaments.

Description

technical field [0001] The present invention relates to the application of a compound, in particular to the application of formononetin in Cryptococcus neoformans. Background technique [0002] Fungal infectious diseases are divided into four categories according to the parts of the fungus that invade the human body: superficial mycosis, skin mycosis, subcutaneous tissue mycosis and systemic mycosis; the former two are collectively called superficial mycosis, and the latter two are also called For deep mycoses. Fungal infectious diseases are divided into the following types according to different fungi: Candida albicans infectious disease, Candida parapsilosis infectious disease, Candida glabrata infectious disease, Cryptococcus neoformans infectious disease, plaster Microsporum infectious disease, Trichophyton rubrum infectious disease, Aspergillus fumigatus infectious disease. [0003] In recent years, with the wide application of broad-spectrum antibiotics, corticostero...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P31/10
Inventor 朱明华
Owner 苏州市马尔泰新材料有限公司
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