131 results about "Methane sulfonate" patented technology

In an example of a method for recovering lead from a lead material including lead sulfide, methane sulfonic acid is selected as a leaching acid for the lead material. The lead material is exposed to a solution including the methane sulfonic acid and i) ferric methane sulfonate or ii) oxygen, which leaches lead from the lead sulfide in the lead material, and generates a liquid leachate including a lead-methane sulfonate salt. The liquid leachate is purified, and lead is recovered from the purified liquid leachate using electrolysis.

An iontophoresis device may be capable of preventing the generation of gas or ions upon energization, and/or may be capable of preventing the alteration of active agent ions due to an electrode reaction. Energization from an electrode to an active agent reservoir may be performed through an ionic liquid. The ionic liquid may include an anion such as PF6-, BF4-, AlCl4-, ClO4-, a hydrogen sulfate ion, bis-trifluoro-alkyl-sulfonyl-imide, or trifluoro-methane-sulfonate, and a cation such as an imidazolium derivative, a pyridinium derivative, a piperidinium derivative, a pyrolidinium derivative, and a tetra-alkyl-ammonium derivative.

The invention relates to a gel-type polymer electrolyte and a preparation method thereof. The gel-type polymer electrolyte membrane is prepared by using amine terminated nitrile rubber as a matrix of the solid electrolyte, dissolving the matrix, lithium salt, epoxidized polysilsesquioxane, and 1-butyl-3-methylimidazolium trifluoro methane sulfonate in an organic solvent, pouring the solvent on a teflon template, and carrying out heat treatment in a baking oven after volatilizing tetrahydrofuran. Compared with the prior art, the operation is simple; the membrane forming is easy; and the prepared membrane is smooth and uniform, has good mechanical properties, high room-temperature conductivity, and stable electrochemical window, and the prepared membrane used as solid electrolyte materials for the lithium ion battery has an application prospect.

The invention discloses a method for detecting methyl methane sulfonate by gas chromatography and tandem mass spectrometry. The method is characterized by comprising the following steps: (1) placing a sample to be detected into a volumetric flask, adding acetonitrile to make up to the volume of 10 to 25 ml, carrying out vortex mixing for 1 to 5 min, carrying out ultrasonic extraction for 10 to 15 min, sieving the obtained product by a filter membrane with the specification of 0.22 [mu]m and carrying out sample injection to detect the methyl methane sulfonate in the sample; (2) under the detection conditions, using a gas chromatography and tandem mass spectrometry combined instrument GC-MS/MS as a detection instrument for detecting the methyl methane sulfonate. In the step (1), 0.05 to 0.50 g of the sample to be detected is taken, accuracy reaches 0.1 mg, the sample to be detected is placed in the volumetric flask, the acetonitrile is added to make up to the volume of 10 to 25 ml, vortex mixing is carried out for 1 to 5 min and ultrasonic extraction is carried out for 10 to 15 min. the method can simply, rapidly, conveniently and efficiently carry out qualitative and quantitative detection on MMS (methyl methane sulfonate) in medicine raw materials, chemical reagents and foods by using the GC-MS/MS.

The invention relates to the technical field of medicament, and provides a novel azole antifungal compound and salts thereof, a preparation method and application thereof. The compound has a chemical structure formula as the right, wherein, X is hydroxide radical; Ar is 2,4-difluorophenyl; R1 is hydrogen or a linear chain with 1 to 6 carbon atoms or low alkyl group with unsaturated or saturated branched chain; and R2 is selected from hydrogen, alkyl, halogen, cyano-group, nitryl and alkoxyl, can be positioned on ortho, meta, para positions of a benzene ring, and can be mono-substituted or multi-substituted. Salts of the compound can be hydrochloride, nitrate, hydrobromide or methane sulfonate. Pharmacological tests prove that the compound has strong antifungal activity, has the advantages of high efficiency, low toxicity, wide antifungal spectrum and the like compared with the prior antifungal medicines applied in clinic, and can be used for preparing antifungal medicines.

The invention discloses a recyclable environment friendly electrolytic stripping solution, a preparation method and a usage method, the recyclable environment friendly electrolytic stripping solution comprises the following components by weight: 10-30% of methanesulfonic acid, 3-10% of tin methane-sulfonate, 1-5% of polyoxytrimethylene polyethenoxy ether, 1-5% of phytic acid and the balance of water. The recyclable environment friendly electrolytic stripping solution has the characteristics of stripping effect, no generation of toxic and harmful gas, recyclable stripping solution, safety, environmental protection, complete satisfaction of environmental requirements of the formula material and stable products, the waste liquid generated during the usage process can be directly and continuously used through electrolysis; the process has the advantages of simplicity, energy efficiency, and convenient usage.

The invention discloses a Paecilomyces thermophila mutant strain and a mutation induction method and application thereof. The mutation induction method includes: Paecilomyces thermophila screened from high-temperature-fermented compost and used for producing high-temperature-resistant and acid-resistant glucose oxidase is used as the original strain, protoplast ultraviolet and ethyl methane sulfonate compound mutation induction is performed, and the screened strain is subjected to budding spore diethyl sulfate-microwave compound mutation induction to obtain the Paecilomyces thermophila mutant strain. The Paecilomyces thermophila mutant strain is preserved in China General Microbiological Culture Collection Center on January 11th, 2016, and the preservation number of the mutant strain is CGMCC No. 13182. Compared with a conventional mutation induction method, the mutation induction method has the advantages that the method is high in efficiency and simple in fast in screening, the productivity of the mutant strain is high, the yield of the mutant stain is 277.65% of that of the Paecilomyces thermophila original strain, fermentation liquor enzyme activity reaches 185U/ml, production cost is lowered, and the glucose oxidase produced by the mutant strain is good in high-temperature resistance and acid resistance and can be used as feed enzyme applied to feed industry.

The present invention relates to a process of preparing benzisoxazole methane sulfonic acid-chloride (BOS—Cl) as an zonisamide intermediate via chlorination of benzisoxazole methane sulfonate. The present invention also discloses a process of preparing zonisamide via amidation of BOS—Cl. More particularly, the present invention provides a process of preparing zonisamide, comprising the steps of: a) chlorinating BOS, salts or esters thereof, with SOCl₂ in an organic solvent and/or in the presence of a catalyst to form BOS—Cl; and b) amidating BOS—Cl in the presence of ammonia selected from the group consisting of aqueous ammonia in a biphasic system, masked ammonia and dry ammonia to form zonisamide.

The invention relates to foliage fertilizer suitable for grape planting and a preparation method. The foliage fertilizer comprises, by weight, 30-35 fermented organic fertilizer, 20-25 parts of urea,10-15 parts of mushroom residue powder, 8-12 parts of plant ash, 6-10 parts of animal bone powder, 3-6 parts of calcium superphosphate, 2-5 parts of potassium phosphate, 1-3 parts of manganese sulfate, 1-3 parts of boric acid, 0.5-1.5 parts of zinc sulfate and 0.2-0.5 part of ethyl methane sulfonate. By adopting the foliage fertilizer and the preparation method, the problem of using waste materials is solved, sufficient and comprehensive nutrient elements are provided for growing of grape plants, nutrition needed by the plants can be quickly supplemented, and the foliage fertilizer is easy forleaves of the plants to absorb, can promote branches and buds to grow and can make grape fruits to expand, so that fruit yield is increased, and yield and income are increased for growers.

The invention provides a method for preparing tin methane sulfonate through hydrogen-free electrolysis, and relates to the field of manufacturing the tin methane sulfonate through industrial electrolytic synthesis and can be used for directly preparing a tin methane sulfonate solution through using an electrolytic process. According to the method provided by the invention, electrolyte is a methanesulfonic acid solution; a cathode of an electrode is a gas diffusion electrode, and an anode of the electrode is solid tin; the cathode and the anode are separated through a membrane; the electrolyte temperature is controlled within a range of 0-60 DEG C; a current density is set within a range of 10-800 A/m<2>; the electrolyte is stopped until a content of free methyl sulfuric acid in the anode electrolyte is up to 0.1-10 g/L; and the anode electrolyte is filtered and concentrated, so as to prepare the tin methane sulfonate solution with different concentrations. The method provided by the invention is suitable for being carried out at the constant temperature and the constant pressure, so that the tin methane sulfonate solution with high purity can be directly obtained. The method provided by the invention has the characteristics of being simple in process, free from separation, high in product purity, low in energy consumption and low in cost.

The invention provides a method for synthesizing crylic acid by catalyzing acetylene carbonyl through palladium. Acetylene, carbon monoxide and water are used as raw materials and are catalyzed to synthesize the crylic acid under the conditions that the reaction temperature is between 15 and 70 DEG C and the pressure is between 1.5 and 6MPa. The adopted catalyst uses palladium diacetate as a main catalyst; the dosage of the main catalyst is less than that of a traditional nickel-copper catalyst and is only 1/50; sulfoacid, such as methane sulfonate, trifluoromethane sulfonic acid, p-toluenesulfonic acid or the like, serves as an aid; an addition amount of the additive is that the ratio of n(-SO3H) to n(Pd2<+>) is equal to 1:1-10:1; and organic phosphine such as 2-pyridyl diphenylphosphine (2-PyPPh2) as a ligand. Compared with the nickel-copper catalyst, the catalyst has remarkable advantages that: under the mild conditions, such as the temperature of 40 DEG C and the pressure of 5 MPa, the catalyst can catalyze the acetylene carbonyl to synthesize the crylic acid at high efficiency, can effectively avoid the acetylene and the crylic acid undergoing polymerization and other side reactions, saves energy, and has safe operation and low operating expense.

The invention mainly provides a medicago sativa plant resistant to herbicide and a method, particularly relates to a method for screening medicago sativa plants resistant to the herbicide by utilizing chemical mutagen EMS (ethyl methane sulfonate) for mutagenesis of medicago sativa, and discloses a culture medium screening method for glyphosate-resisting medicago sativa plants. The method is characterized by including the following steps: (1) germinating seeds by an MS culture medium; (2) performing dosage screening; (3) subjecting medicago sativa seeds to mutagenesis by median lethal dose of the EMS; (4) screening the glyphosate-resisting medicago sativa plants; (5) rescreening the resistant plants. The method has the advantages of being simple and easy to implement, taking effect fast and capable of allowing single plants of herbicide-resistant medicago sativa to be obtained within a short time. A mutagenesis way is adopted. The chemical mutagen EMS is utilized to mutate the medicago sativa seeds to generate point mutation, the single plants of the herbicide-resistant medicago sativa are screened by two ways of the culture medium and soil screening, new germplasm resources are provided for conventional breeding, and certain references are provided for herbicide-resistant breeding of other plants.

Sulfonic acid type semi-bright pure-tin electroplating liquid comprises methanesulfonic acid with the concentration being 100-120g/L, tin methane sulfonate with the concentration being 200-250g/L, a brightener with the concentration being 2-8g/L, a stabilizer with the concentration being 5-10g/L, a lubricant with the concentration being 10-15g/L and a grain refiner with the concentration being 2-5g/L. The stabilizer comprises ethyl alcohol with the concentration being 2.5-4 mol/L, sodium sulfite with the concentration being 3.0-5.0 mol/L and ferrous sulfate with the concentration being 0.5-1.5 mol/L. According to the semi-bright pure-tin electroplating liquid, alkyl stannous sulfonate is adopted as main salt, and the sulfonic acid type semi-bright pure-tin electroplating liquid is high in dispersing capacity, stable and efficient under the cooperative effect of the brightener, the stabilizer, alkyl sulfonate, a wetting agent, the grain refiner and other components.

A method for producing mutant of hemerocallis middendorffii by in vitro mutagenesis of ethyl methane sulfonate (EMS) amis to provide an EMS in vitro mutagenesis method for breed improvement of hemerocallis and creation of new germplasm resources and to obtain a target variant strain. The method for producing the mutant of the hemerocallis middendorffii by the in vitro mutagenesis of the ethyl methane sulfonate adopts the 1 to 2cm flower buds in normal growth and development state of the hemerocallis middendorffii as materials, inoculates callus induced by taking ovaries as explants to a differential medium, and green buds are differentiated. After the callus with buds is subjected to differentiation culture for 10 days, a callus block is treated with EMS semi-lethal dose at a concentration of 0.75-1.0 percent (w/v). The treated callus is inoculated to the differentiation medium for differentiation culture to obtain regenerated plants. When the regenerated plants grow to 1 to 2 cm high, the regenerated plants are cut down from the callus and put in a subculture medium to conduct subculture for 15 days, hemerocallis septoria tritici toxin semi-lethal dose at a concentration of 40 percent (v/v) is taken as directional selection pressure for stress screening, and disease-resistant mutant plants are obtained.

The invention discloses a rustproof repairing method for a reinforced concrete structure, belonging to the technical field of building materials. The rustproof repairing method provided by the invention adopts a method for repairing a composite aluminum wire mesh by cement-based polymer repairing mortar to repair the reinforced concrete with cracks. The polymer repairing mortar comprises the following components in percentage by weight: 35% of high-alumina cement, 11% of talcum powder, 43% of quartz sand, 4% of anhydrous anhydrite powder, 2% of silane modified phenylpropyl glue powder, 1.3% of water reducing agent, 0.7% of shrinkage reducing agent and 3% of tin methane sulfonate. The rustproof repairing method provided by the invention can remarkably improve the mechanical properties of the reinforced concrete structure and also can remarkably improve the rustproof capacity and durability of the reinforced concrete structure. Moreover, the rustproof repairing method has a simple technical process and low material cost, and can be extensively applied to the reinforcing field of the concrete structures.

The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate salt by precipitation. This process minimizes decomposition of deferoxamine B.

The invention relates to a method for preparing a solution of tin methane sulfonate for electroplating. The method is characterized by comprising the following steps that: 1) an anion exchange membrane is used for dividing an electrolytic cell into a cathode chamber and an anode chamber, wherein the electrolyte used in the anode chamber is a solution of methane sulfonic acid with the mass concentration of between 20 and 40 percent, and the electrolyte used in the cathode chamber is a solution of methane sulfonic acid with the mass concentration of between 10 and 50 percent; the anode in the anode chamber is made of a tin plate or tin flower, and the cathode in the cathode chamber is made of a tin plate or copper plate; and 2) the anode and the cathode are connected with a DC power supply for electrolysis, the electrolytic temperature is between 20 and 60 DEG C, and under the action of the DC with the voltage of 1.8 to 3V, the anode is subjected to anodic dissolution and enters the anode chamber; and when the concentration of tin ion in the anode chamber reaches between 100 and 130g/L, the electrolysis stops, and the electrolyte in the anode chamber is taken out and filtered, and the filtrate is subjected to vacuum concentration at a temperature of between 40 and 120 DEG C, so that the solution of tin methane sulfonate, of which the content of tin ion is 300 to 310g/L, can be obtained. The method has the advantages of less equipment investment, simple process and high product purity.

The invention relates to a method for preparing nafamostat hydrochloride and nafamostat mesylate. The method comprises the following steps of: reacting n-guanidine benzoyl chloride hydrochloride with a methanesulfonic acid 6-guanyl-2-isonaphthol compound under an action of an alkali organic solvent to prepare nafamostat hydrochloride, wherein the alkali organic solvent does not comprise dicyclohexyl carbodiimide; and reacting the nafamostat hydrochloride and the methanesulfonic acid under a mixed liquid of the water and the organic solvent to prepare the nafamostat mesylate. The preparation method is simple in process, high in yield, low in content of impurities and suitable for industrial production.

The invention discloses a method for preparing micro-nano needle conical structure for copper interconnection by electrochemical deposition; a conductive base material is used as a cathode and is placed in a electroplating solution containing copper ions, complexing agents and additives, after current is applied, the electrocrystallization grows vertically along one-dimension which is vertical to the surface direction, thereby the micro-nano needle conical structure for copper interconnection is formed on the conductive base material surface; the copper ion is provided by copper methane sulfonate or is mainly provided by copper methane sulfonate, and is supplemented by more than one or two of cupric chloride, copper pyrophosphate and cupric nitrate. The invention provides a preparation method which has the advantages of simple process, low cost without special requirements for substrate shape and material, and is suitable for industrialized batch production of micro-nano needle conical structure for copper interconnection; in addition, according to the preparation method provided by the invention, a copper needle conical crystal structure can be directly formed on the surface of the required base material, and the structure can be used as device and material, thereby providing possibility for realization of industrialized production and wide application.

The invention discloses a method for synthesis of 1-(4, 5-dihydro-2-thiazolinyl)-3-mercaptoazetidine hydrochloride. With 2-methylthio-2-thiazoline (I) as the raw material, the method of the invention comprises the steps of: in the presence of alkali, reacting 2-methylthio-2-thiazoline (I) with 3-hydroxyazetidine hydrochloride so as to obtain 1-(4, 5-dihydro-2-thiazolinyl)-3-hydroxyazetidine (II), and reacting (II) with methyl sulfonylchloride in the presence of alkali so as to obtain 1-(4, 5-dihydro-2-thiazolinyl)-3-methane sulfonate group azetidine (III), subjecting (III) to a reaction with potassium thioacetate so as to obtain 1-(4, 5-dihydro-2-thiazolinyl)-3-thioacetic acid ester group azetidine (IV), in the presence of alkali, subjecting (IV) to hydrolysis and then to acidification with dilute hydrochloric acid, thus obtaining the 1-(4, 5-dihydro-2-thiazolinyl)-3-mercaptoazetidine hydrochloride (V). With easily available and inexpensive starting material, the method of the invention simplifies the synthesis route, improves the raw material utilization ratio and the overall yield. An intermediate obtained in the reaction can be subjected to refinement by a recrystallization method or to a next reaction directly, so that the yield is high and the "three wastes" produced during the reaction process are few. In addition, with low cost, the method of the invention is beneficial for industrial production.

The invention provides electroplating liquid of a cyanide-free silver plated tin alloy and an electroplating method. Silver methane sulfonate and tin methane sulfonate are used as main salt of a silver plated tin alloy; carving sulfonic acid is used as a complexing agent; other additive components are compounded for improving the effect; cyanide-free electroplating silver tin alloy solution contains no cyanide, is free of poison and harm to environments and human bodies, is reasonable in formula, and is excellent in stability; pulse electroplating is used during electroplating, so that such problems as high plating layer strain and brittleness and weak binding force are effectively solved, and a plating layer with good binding performance with a basal body, low strain and good compactness and brightness is obtained; the obtained silver plated tin alloy layer is suitable for application of reflecting layers, high electric conducting layers and brazing plating layers in the fields of photoelectricity and microelectronics; and the formed plating layer can improve the microelectronic packing electric conductivity and reliability, and largely reduces the signal distortion caused by circuit resistance.

An improved process for the preparation of Montelukast and its pharmaceutically acceptable salts comprises of reacting (S) Benzenepropanol α-[3-[2-(7-chloro2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate compound of formula (II) with 1-(mercapto methyl)cyclo propane acetic acid or its ester or nitrile in presence of alkali or alkaline carbonates and/or alkali or alkaline earth metal alkoxide in a suitable polar aprotic solvent with or without combination of C₁-C₄ alcoholic solvents and then treating with organic amine in a suitable ester and/or acetone and/or aliphatic or aromatic hydrocarbon solvents, and converting the corresponding amine salt compound of montelukast into its sodium salt compound of formula (I) using sodium ion source in methanol, without converting into montelukast free acid.