Antifungal medicine composition

A technology of antifungal drugs and compositions, applied in the field of pharmacy, can solve problems such as high recurrence rate and large toxic and side effects

Inactive Publication Date: 2005-11-02
XIANGBEI WELMAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although there are many types of antifungal agents, they also have

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] In vitro antibacterial effect of cyclosporine A or FK-506 combined with fluconazole against Trichophyton rubrum, Microsporum lanoides, Trichophyton gypsumiformis, Epidermophyton flocculum and Candida albicans

[0042] The experimental method refers to the liquid-based dilution method antifungal susceptibility testing scheme (National Committee for Clinical Laboratory Standards. 1998. Reference method for broth dilution antifungal susceptibility testing of conidium-forming filamentous fungi. Proposed standard M38- P. National Committee for Clinical Laboratory Standards, Wayne, Pa.)

[0043] (1) Bacterial solution preparation:

[0044] Add 1ml of sterilized 0.85% normal saline to the fungal slant inoculated on the SDA medium on the slant, gently suck out the mixture of spores and hyphae with a sterilized dropper, count on a hemocytometer, and adjust the bacterial solution with RPMI 1640 culture solution Concentration to 0.4-5×10 4 CFU / ml.

[0045] (2) Liquid preparatio...

Embodiment 2

[0056] In vitro antibacterial effect of cyclosporine A (CsA) or FK-506 and bifonazole against Trichophyton rubrum, Microsporum lanoides, Trichophyton gypsumoides, Epidermophyton flocculum, and Candida albicans

[0057] The antibacterial effect was measured with the same test method as in Example 1, the only difference being that fluconazole was replaced with bifonazole. The results are shown in Table 2.

[0058] drug

Bai Nian

red hair

wool

plaster

Xu table

CsA

＞64

＞64

＞64

＞64

＞64

FK-506

＞64

＞64

＞64

＞64

＞64

BIF

2.5

0.125

0.125

0.5

0.25

BIF+CsA (2μg / ml)

＜0.125

＜0.125

＜0.125

0.125

＜0.125

BIF+FK-506 (2μg / ml)

＜0.125

＜0.125

＜0.125

0.125

＜0.125

[0059] Note: Candida albicans = Candida albicans

[0060] Trichophyton ...

Embodiment 3

[0065] In vitro antibacterial effect of cyclosporine A (CsA) or FK-506 combined with terbinafine against Trichophyton rubrum, Microsporum lanoides, Trichophyton gypsumoides, Epidermophyton flocculus, Candida albicans

[0066] The antibacterial effect was measured with the same test method as in Example 1, except that the fluconazole was replaced with terbinafine. The results are shown in Table 3.

[0067] drug

Bai Nian

red hair

wool

plaster

Xu table

CsA

＞64

＞64

＞64

＞64

＞64

FK-506

＞64

＞64

＞64

＞64

＞64

TEB

12.5

0.0025

0.01

0.005

0.005

TEB+CsA (2μg / ml)

6.25

＜0.00125

0.00125

＜0.00125

＜0.00125

TEB+FK-506 (2μg / ml)

1.5625

＜0.00125

0.0025

＜0.00125

＜0.00125

[0068] Note: Candida albicans = Candida albicans

[0069] Trichophyton rubrum = Trichophyton rubrum

[0070] Wool =...

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PUM

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Abstract

The present invention discloses one kind of antifungal medicine composition for treating superficial fungous diseases. The antifungal medicine composition contains cell synthesis factor inhibitor type immunological inhibitor; azepexole or allyl amine type antifungal agent; and pharmaceutically acceptable carrier. The immunological inhibitor and the antifungal agent account for 0.001-99.9 % of the total composition and has weight ratio of 0.01-100. The composition of the present invention may be used in treating tinea corporis, tinea capitis, tinea manuum and other superficial fungous diseases.

Description

technical field [0001] The invention relates to the field of pharmacy, and more specifically relates to an antifungal pharmaceutical composition for treating superficial mycosis, the composition contains immunosuppressants and antifungal agents such as azoles or allylamines. Background technique [0002] Infections caused by fungi are generally divided into two categories: superficial mycoses and deep mycoses. [0003] Deep fungal infections are usually caused by Candida albicans, Cryptococcus neoformans, etc. [0004] Superficial fungal infections are usually caused by various phytophytes, and there are many types, which can be divided into Trichophyton, Epidermophyton, Microsporum, etc. The main pathogenic species are Trichophyton rubrum, Gypsum Superficial fungi such as Trichophyton-like, Microsporum canis, and Epidermophyton flocculus. Often invade skin, hair, nail (toe) etc., the disease that is caused by them is called dermatophytosis, is referred to as " ringworm " ...

Claims

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Application Information

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IPC IPC(8): A61K45/00
Inventor 俞强陈嘉王希玲贺娜张怡轩戴端芳
Owner XIANGBEI WELMAN PHARMA CO LTD
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