Bibenzil compound 13,13'-O-iso-propylidene riccardia D and its extraction and separation method and use

The technology of a compound and acetone is applied to the application field in the preparation of antifungal drugs, and can solve the problems of unseen and few antifungal compounds, and achieve the effects of strong antifungal effect, novel structure and good application prospect.

Inactive Publication Date: 2006-06-28
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, more than 80 bibenzyl compounds have been obtained from liverworts, but there is no report on the substitution of isopropylidene on the bibenzyl structure
[0003] At present, due to the lack of antifungal compounds from natural sources, people have done a lot of work in the development of new drugs and the use of natural raw materials to extract new drugs, trying to find a strong antifungal effect and overcome the resistance of synthetic antibacterial drugs. However, among the many reports retrieved, there is no report about 13,13'-O-isopropylidene phylloxane D (13,13'-O-isoproylidenericcardin)

Method used

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  • Bibenzil compound 13,13'-O-iso-propylidene riccardia D and its extraction and separation method and use
  • Bibenzil compound 13,13'-O-iso-propylidene riccardia D and its extraction and separation method and use
  • Bibenzil compound 13,13'-O-iso-propylidene riccardia D and its extraction and separation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The ground money (Marchantia polymorpa L.) collected from the area of ​​1000-1500 meters above sea level in Mount Emei, Sichuan Province was naturally dried and crushed to 8.95Kg, soaked in 8 times the volume of ground money in ether at 28°C for 5 days, filtered under normal pressure, collected ether and extracted Liquid I, repeated 4 times, combined extract I. Soak the medicinal dregs after the last extraction with 3 times the amount of methanol at 28°C for 4 times, each time for 3 days, filter under normal pressure, collect the methanol extracts, combine them, and concentrate under reduced pressure (vacuum degree 0.09Mpa) in a rotary evaporator at 60°C To obtain the methanol extract, extract the extract 3 times with ether equivalent to 3 times the amount of the extract, collect and combine the ether extract II, combine the two parts of the ether solution I and II, and then distill at 60°C to a fluid extract. Evaporate to dryness to obtain the total ether extract. Mix...

Embodiment 2

[0045] Naturally dry and crush Marchantia polymorpa L. collected from Emei Mountain, Sichuan Province, at an altitude of 1000-1500 meters to obtain 9.50Kg, soak in ether at 23°C for 4 days at 5 times the volume of Marchantia, filter under normal pressure, and collect ether for extraction. Solution I, repeated 6 times, combined extract I; soaked the medicinal dregs after the last extraction with 2 times the amount of methanol at 35°C for 5 times, each time for 2 days, filtered under normal pressure, collected methanol extracts, combined, and used a rotary evaporator Concentrate at 70°C under reduced pressure (vacuum degree 0.09Mpa) to obtain the methanol extract, extract the extract 4 times with ether equivalent to 2 times the amount of the extract, collect and combine the ether extract II, and combine the two parts of the ether solution I and II Afterwards, it was distilled at 70°C to a liquid extract, and evaporated to dryness naturally to obtain the total ether extract. Mix ...

Embodiment 3

[0047] Naturally dry and crush the picked Marchantia polymorpa L. to obtain 8.25Kg, soak 10 times the volume of Marchantia polymorpa in ether at 35°C for 7 days, filter under normal pressure, collect the ether extract I, repeat 3 times, and combine the extract I . Soak the medicinal dregs after the last extraction with 4 times the amount of methanol at room temperature for 3 times, each time for 2 days, filter under normal pressure, collect the methanol extracts, combine them, and concentrate on a rotary evaporator at 50°C under reduced pressure (vacuum degree 0.09Mpa) to obtain For the methanol extract, extract the extract twice with ether equivalent to 5 times the amount of the extract, collect and combine the ether extract II, combine the two parts of the ether solution I and II, and distill at 50°C to a liquid extract, and let it evaporate naturally. Dry to obtain the total ether extract. Mix the above-mentioned ether total extract with 3 times the amount of 300 mesh sili...

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Abstract

The invention relates to a compound of the general formula (1): 13, 13'-O-isopropylidene substrate Jungermanniaceae D. The invention also relates to a method of extracting and separating the compound and uses of the compound in preparation of antifungal drug. The compound exploits a new road to develop and apply the new generation antifungal drug derived from nature.

Description

technical field [0001] The present invention relates to a bibenzyl compound and its extraction and separation method and application, in particular to a bibenzyl compound 13,13'-O-isopropylidene riccardin D (13,13'-O-isoproylidenericcardin) and The method for extracting and separating it from Mossia genus and its application in the preparation of antifungal drugs. Background technique [0002] Bibenzyl compounds are more common in bryophytes, structurally with C 6 -C 2 -C 6 The mother nucleus and its dimers exist, and are divided into different structural types based on the connection between the benzene rings, usually named according to the plant source; due to the different substituents of the benzene rings, many compounds are produced, named in turn according to the structural type they belong to. Such as dichantin B-H, J-L, phylloxin C, isophylloidin C, etc. (Susanne F., Ulrich HM., Brigirl DN., et al Biosynthesis of Cyclic Bisbibenzyls in Marchantia polymorpha. Phyto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/08A61K31/55A61P31/10C07D321/00C07D313/00
Inventor 娄红祥牛冲范培红
Owner SHANDONG UNIV
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