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Ginseng-royal jelly nanoemulsion oral liquid and preparation method thereof

A technology of milk oral liquid and royal jelly, which is applied in the field of nanoemulsion oral liquid containing ginseng royal jelly and its preparation, can solve the problems of not being retrieved, and achieve the effects of increasing solubility, high transparency, and good thermodynamic stability

Inactive Publication Date: 2014-04-23
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are 19 Chinese patents on "Nanoemulsion Oral Liquid" retrieved, but no patent application for "Ginseng Royal Jelly Nanoemulsion Oral Liquid" was retrieved. Therefore, a nanoemulsion oral liquid based on royal jelly and ginseng was developed to establish a The national innovative nanoemulsion oral liquid, a big brand with independent intellectual property rights, not only exerts the health benefits of ginseng and royal jelly, but also upgrades the technology of oral liquid, which has important social significance and economic benefits

Method used

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  • Ginseng-royal jelly nanoemulsion oral liquid and preparation method thereof
  • Ginseng-royal jelly nanoemulsion oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Select the oil phase, surfactant and co-surfactant by calculating the HLB value, and draw the pseudo-ternary phase diagram according to the ratio of 9:1-1:9 to determine the optimal ratio.

[0040] 2) Accurately weigh 0.4g of lecithin, 1.0g of sucrose ester, 2.5g of propylene glycol, 0.55g of olive oil, 0.19g of ginsenoside, 0.5g of royal jelly, and 6.0g of honey water for later use.

[0041] 3) Put lecithin, sucrose esters, propylene glycol and olive oil into a beaker, stir quickly in a water bath at 25°C, then slowly add honey water dropwise, and keep stirring until a clear and transparent light yellow solution appears and then adding ginsenosides and royal jelly into the system to obtain an oil-in-water type ginseng royal jelly nanoemulsion oral liquid with a particle size of less than 100 nm.

[0042] 4) Carry out animal experiments, calculate pharmacokinetic parameters, and analyze its targeting and gastrointestinal absorption mechanism.

Embodiment 2

[0044] 1) Select the oil phase, surfactant and co-surfactant by calculating the HLB value, and draw the pseudo-ternary phase diagram according to the ratio of 9:1-1:9 to determine the optimal ratio.

[0045] 2) Accurately weigh 0.4g of lecithin, 3.0g of propylene glycol, 0.6g of olive oil, 0.35g of ginsenoside, 0.5g of royal jelly, and 6.0g of honey water for later use.

[0046] 3) Add lecithin, sucrose esters, propylene glycol and olive oil into a beaker, stir quickly in a water bath at 25°C, then slowly add honey water dropwise, and keep stirring until a clear, transparent light yellow solution appears , and then add ginsenoside and royal jelly into the system to obtain the oil-in-water type ginseng royal jelly nanoemulsion oral liquid with a particle size of less than 100 nm.

[0047] 4) Carry out quality testing and animal experiments, calculate pharmacokinetic parameters, and analyze its targeting and gastrointestinal absorption mechanism.

Embodiment 3

[0049] 1) Select the oil phase, surfactant and co-surfactant by calculating the HLB value, and draw the pseudo-ternary phase diagram according to the ratio of 9:1-1:9 to determine the optimal ratio.

[0050] 2) Weigh 0.4g of lecithin, 0.5g of caprylic acid macrogol glyceride, 0.5g of lauric acid sucrose ester (LWA-1570), 3.0g of propylene glycol, 0.55g of isopropyl myristate, and 0.25g of ginsenoside g, royal jelly 0.5g, distilled water 5.5g for subsequent use.

[0051] 3) Put lecithin, caprylic capric acid macrogol glyceride, lauric acid sucrose ester (LWA-1570), propylene glycol and isopropyl myristate into a beaker, and rapidly in a water bath at 25°C Stir evenly, then slowly add distilled water dropwise to it, and keep stirring until a clear and transparent light yellow solution appears, then add ginsenoside and royal jelly into the system to obtain an oil-in-water ginseng royal jelly nanoemulsion oral liquid with a particle size of less than 100nm .

[0052] 4) Carry ou...

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Abstract

The invention relates to the technical fields of a nanoemulsion drug delivery system in the pharmaceutics and gastrointestinal transmembrane transport and absorption in the biopharmaceutics, and specifically relates to a nanoemulsion oral liquid containing ginseng and royal jelly, and a preparation method thereof. The nanoemulsion oral liquid comprises a natural or food-grade emulsifier and an oil phase, and also an aqueous phase, wherein the aqueous phase contains fruit juice water, vegetable juice water or honey water and double distilled water; the emulsifier / co-emulsifier accounts for 10.30%-80.60%, the oil phase accounts for 1.0%-40.80%, ginsenoside accounts for 0.10%-38.0% and the royal jelly accounts for 0.10%-25.0%, the balance is the aqueous phase, and the total ingredients are 100%. The results of animal experiments show that the oral liquid is good in gastrointestinal transmembrane transport and absorption effects, non-toxic, harmless and free of pollution.

Description

technical field [0001] The invention relates to the technical field of nanoemulsion drug-carrying system and oral liquid gastrointestinal transmembrane transport and absorption, and belongs to the research field of pharmacy nanoemulsion new technology and biopharmaceutical oral liquid gastrointestinal transmembrane transport absorption, and specifically relates to a drug containing Nanoemulsion oral liquid of ginseng royal jelly and its preparation method. Background technique [0002] Ginseng royal jelly is a health product made by adding ginseng ingredients to royal jelly and adding glucose, sorbic acid, etc. The combination of the two can condense the natural essence, which can enhance body resistance, delay aging, regulate physiological functions, and fight cancer. , antibacterial, anti-inflammatory, promote tissue regeneration and beauty effects. It has a certain auxiliary effect on hepatitis, rheumatoid arthritis, bronchial asthma, anemia and recovery of vitality afte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K36/258A61K35/64A61P39/00A23L1/076A23L21/20A61K35/644
Inventor 丁志英杜娟刘雅竹张越
Owner JILIN UNIV
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