Use of cinnamyl-(6'-O-alpha-L- arabopyranose)- O-beta-D-glucopyranoside in preparing antidepressant medicine

A technology of arabinopyranose and glucopyranose, which is applied in the field of preparation of antidepressant drugs, and can solve the problems that the antidepressant effect of monomer rosavin has not been reported.

Inactive Publication Date: 2009-06-17
上海嘉达信息科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] At present, the antidepressant effect of monomer rosavin in animal experiments has not been reported

Method used

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  • Use of cinnamyl-(6'-O-alpha-L- arabopyranose)- O-beta-D-glucopyranoside in preparing antidepressant medicine
  • Use of cinnamyl-(6'-O-alpha-L- arabopyranose)- O-beta-D-glucopyranoside in preparing antidepressant medicine
  • Use of cinnamyl-(6'-O-alpha-L- arabopyranose)- O-beta-D-glucopyranoside in preparing antidepressant medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0139] Preparation of rosavin ordinary capsules

[0140] Prescription: rosavin 40mg

[0141] Lactose 155mg

[0142] Carboxymethyl Starch Sodium 5mg

[0143] 5% povidone (K30) in 70% ethanol solution

[0144] Take rosavin, lactose, and sodium carboxymethyl starch through a 80-mesh sieve and mix evenly, add 5% povidone K30 in 70% ethanol solution to make a soft material, pass through a 40-mesh sieve to granulate. 50-60 ℃ oven blast drying. The dry granules are sieved through a 40-mesh sieve. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.

Embodiment 2

[0146] Preparation of rosavin ordinary capsules

[0147] Prescription: rosavin 40mg

[0148] Microcrystalline Cellulose 155mg

[0149] Crospovidone 5mg

[0150] 5% povidone (K30) in 70% ethanol solution

[0151] Take rosavin, microcrystalline cellulose, and cross-linked povidone through a 80-mesh sieve and mix evenly, add an appropriate amount of 5% povidone K30 in 70% ethanol solution to make a soft material, and pass through a 40-mesh sieve to granulate. 50-60 ℃ oven blast drying. The dry granules are sieved through a 40-mesh sieve. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.

Embodiment 3

[0153] Preparation of rosavin ordinary capsules

[0154] Prescription: rosavin 40mg

[0155] Povidone (K30) 160mg

[0156] Proper amount of ethanol

[0157] Magnesium Stearate 1mg

[0158] Get rosavin and povidone and add appropriate amount of ethanol to heat and dissolve, put the rotary evaporator to remove ethanol, cool, pulverize, pass through a 40 mesh sieve, add the prescribed amount of magnesium stearate, and mix well. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.

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PUM

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Abstract

The invention relates to applications of a compound cinnamyl-(6'-O-alpha-L-arabopyranose)-O-beta-D-glucopyranoside in pharmaceutical field. The compound can effectively resist blepharoptosis caused by reserpine or akinesia, resist small mouse thrill caused by L-5-HT, resist small mouse tail suspension or acquired desperation depression by a forced swinging method, strengthen L-dopa behavioural effect, and has no exciting or inhibiting effect to nerve centres. The action mechanism thereof may be related to breaking reuptake of NA, DA transmittances so as to increase concentration of the two transmittances in synaptic spaces. The compound has no toxic reactions in acute toxicity experiences on mice so that the compound with experience dosage has relatively high security and good anti-depression effect and can be used to treat depression.

Description

technical field [0001] The present invention relates to the use of chemical substances in the field of medicine. More specifically the application of the compound cinnamyl-(6'-O-α-L-arabinopyranose)-O-β-D-glucopyranoside (rosavin) in the preparation of antidepressant drugs Background technique [0002] Compound cinnamyl-(6'-O-α-L-arabinose)-O-β-D-glucopyranoside (rosavin), its structural formula is: [0003] [0004] Molecular formula: C 20 h 28 o 10 ; [0005] Molecular weight: 428.44 [0006] Appearance: white powder; [0007] CAS: 84954-92-7; [0008] Melting point: 171-173°C (ethanol); [0009] Optical rotation: -56.5° (chloroform / methanol 1:1); UVλ max 252nm [0010] Belongs to phenylpropanoid glycosides, originally in the Crassulaceae plant Rhodiola rosea. [0011] In 1983, G.G.Zapesochnaya and V.A.Kurkin first isolated three new cinnamyl alcohol glycoside compounds in the rhizome of Rhodiola rosea, and named them: rosin, rosavin, rosarin[]. [0012] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61P25/24
Inventor 惠永正吴伟泳杨翎
Owner 上海嘉达信息科技有限公司
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