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Use of cinnamyl-(6'-O-alpha-L- arabopyranose)- O-beta-D-glucopyranoside in preparing antidepressant medicine
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A technology of arabinopyranoside and glucopyranoside, which is applied in the application field of preparing antidepressant drugs, can solve the problem that the antidepressant effect of monomer rosavin has not been reported and the like
Inactive Publication Date: 2012-03-21
上海嘉达信息科技有限公司
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[0015] At present, the antidepressant effect of monomer rosavin in animal experiments has not been reported
Method used
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[0142] Take rosavin, lactose, and sodiumcarboxymethyl starch through a 80-mesh sieve and mix evenly, add 5% povidone K30 in 70% ethanol solution to make a soft material, pass through a 40-mesh sieve to granulate. 50-60 ℃ oven blast drying. The dry granules are sieved through a 40-mesh sieve. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.
[0149] Take rosavin, microcrystallinecellulose, and cross-linked povidone through a 80-mesh sieve and mix evenly, add an appropriate amount of 5% povidone K30 in 70% ethanol solution to make a soft material, and pass through a 40-mesh sieve to granulate. 50-60 ℃ oven blast drying. The dry granules are sieved through a 40-mesh sieve. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.
[0156] Get rosavin and povidone and add appropriate amount of ethanol to heat and dissolve, put the rotary evaporator to remove ethanol, cool, pulverize, pass through a 40 mesh sieve, add the prescribed amount of magnesiumstearate, and mix well. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.
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Abstract
The invention relates to applications of a compound cinnamyl-(6'-O-alpha-L-arabopyranose)-O-beta-D-glucopyranoside in pharmaceutical field. The compound can effectively resist blepharoptosis caused by reserpine or akinesia, resist small mouse thrill caused by L-5-HT, resist small mouse tail suspension or acquired desperation depression by a forced swinging method, strengthen L-dopa behavioural effect, and has no exciting or inhibiting effect to nerve centres. The action mechanism thereof may be related to breaking reuptake of NA, DA transmittances so as to increase concentration of the two transmittances in synaptic spaces. The compound has no toxic reactions in acute toxicity experiences on mice so that the compound with experience dosage has relatively high security and good anti-depression effect and can be used to treat depression.
Description
technical field [0001] The present invention relates to the use of chemical substances in the field of medicine. More specifically the application of the compound cinnamyl-(6'-O-α-L-arabinopyranose)-O-β-D-glucopyranoside (rosavin) in the preparation of antidepressant drugs Background technique [0002] Compound cinnamyl-(6'-O-α-L-arabinose)-O-β-D-glucopyranoside (rosavin), its structural formula is: [0003] [0004] Molecular formula: C 20 h 28 o 10 ; [0005] Molecular weight: 428.44 [0006] Appearance: white powder; [0007] CAS: 84954-92-7: [0008] Melting point: 171-173°C (ethanol); [0009] Optical rotation: -56.5° (chloroform / methanol 1:1); UVλ max 252nm belongs to the phenylpropanoid glycosides, originally in the CrassulaceaeplantRhodiola rosea. [0010] In 1983, G.G.Zapesochnaya and V.A.Kurkin first isolated three new cinnamyl alcoholglycoside compounds in the rhizome of Rhodiola rosea, and named them: rosin, rosavin, rosarin[]. The three compound...
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