52results about How to "Good antidepressant activity" patented technology

The present invention relates to the preparation process of extract containing three active components including hypericin, Hyperforin and flavones in the total content not less than 50% from hypericum perforatum or other congeneric plant. The three active components are separated from the polar solvent extracted liquid via biphase extraction with non-polar solvent selected based on their difference in polarity. They are then purified separately based on their difference in acid-base property to obtain the extract A with high hypericin and flavones content and extract B with high Hyperforin content. The two extracts are merged through dissolution to obtain hypericum perforatum extract with total active component content not less than 50%. The extract has the obvious activity of resisting depression and may be used as the material of depression treating medicine or functional food.

The invention discloses an antidepressant compound preparation and a preparation method thereof, which is composed of the following raw materials: Hypericum perforatum, Radix Paeoniae Alba, Gardenia, Albizia Julibrissin and Cortex Moutan. Raw materials are weighed in proportion to obtain extracts respectively, and mixed to form a compound preparation. The compound preparation prepared by the present invention has the advantages of simple preparation, safety, less toxic and side effects, no dependence, etc., and can effectively relieve depression.

The invention provides a compound with anti-depression activity and a preparation method and application of the compound, and relates to the technical field of medicine and chemical engineering. The structural formula is as shown in the specification. The structure of the compound is different from that of an existing morpholine compound; and the compound has a bran-new molecular structure and also has good anti-depression activity.

An application of helicidum analog in preparing medicines for preventing and treating depression is disclosed. Its chemical structure is also disclosed.

The invention discloses a total flavonoid extract with antidepressant effect and a preparation method and application thereof. The total flavonoid extract is prepared according to the following preparation method: adding an extraction solvent to dodder seed powder, heating and refluxing for extraction, combining filtrates, and concentrating to obtain The extract; the extract is added to the polyamide column and the macroporous resin column respectively for chromatography, and the obtained eluate is concentrated to obtain the total flavonoid extract of Dodder. The total flavonoids extract prepared by the invention has high purity, and the experimental results show that the total flavonoids of Dodder can obviously shorten the immobility time of TST and FST of CUMS mice without affecting their autonomous activities, indicating that the total flavonoids of Dodder has strong anti-inflammatory properties. Depressive effect and no central excitatory or inhibitory effect. Moreover, total flavonoids from Dodder can activate the TXNIP / NLRP3 inflammasome signaling pathway, which proves that total flavonoids from Dodder can exert antidepressant effect by regulating the TXNIP / NLRP3 inflammasome pathway.

The invention discloses xanthone compounds and their use in depression resistance. The xanthone compounds are compounds shown in the structural formula (I) or their pharmaceutically acceptable salts. An experiment proves that the xanthone compounds have good depression-resistant activity and a part of the xanthone compounds have depression-resistant activity superior to that of venlafaxine. Therefore, the xanthone compounds and their pharmaceutically acceptable salts can be used for preparation of depression-resistant drugs.

The invention relates to a total extract and active parts of betel pinnatifida, a preparation method thereof and an application in preparation of medicine or food for preventing or treating depression. The present invention has the advantages that: the present invention's betel extract and its ethyl acetate extraction part have significant antidepressant activity, and can be used to prepare antidepressant drugs or food; medication is safe, without central excitation or inhibition; the present invention finds high efficiency and low Toxic drugs for the treatment of depression provide a new source for seeking new antidepressants.

The invention discloses a thiazolamide derivative with antidepressant activity, which can be used for preparing antidepressant drugs, broadens the scope of existing antidepressant compounds, and can be used as a leading compound for further optimization. Compared with fluoxetine hydrochloride, the compounds of the present invention have better antidepressant activity. The compound of the present invention has a simple preparation route, mild conditions, and is easy for industrialized large-scale production.

The invention belongs to the technical field of medicine and relates to a pharmaceutical composition with an anti-depression effect. The pharmaceutical composition is prepared from, by weight, 5-100 parts of morinda roots, 5-100 parts of fructus gardenia, 5-100 parts of poria cocos and 1-50 parts of fermented soybeans. The pharmaceutical composition is a refined formula determined with the theory of traditional Chinese medicine as the basis and the modern pharmacological study result as indexes, and can remarkably relieve somatic symptoms such as vigor deficiency, sleep disorder and anorexia of patients while treating mental symptoms such as the amorphous type, hebetude, retardation of thinking and bulesis reduction of depression patients.