3results about How to "Simple preparation route" patented technology

The present application provides a gelatin particle and a preparation method thereof, and a hemostatic fluid gelatin composition. The gelatin particle is a cross-linked gelatin particle, and the preparation raw material of the gelatin particle comprises gelatin and a high molecular material containing amino and / or carboxyl; the preparation process of the gelatin particle comprises the steps of forming a gelatin gel from the gelatin and crushing the gelatin gel, wherein the high molecular material is added to mix with the solution of the gelatin or the gelatin gel before or after the formation of the gelatin gel. The gelatin particle and the hemostatic fluid gelatin of the present application can quickly absorb the moisture in the blood after being applied to a bleeding wound, thereby increasing the concentration of red blood cells, blood coagulation factors and the like in the blood, accelerating the endogenous blood coagulation mechanism, and having a good hemostatic effect.

This invention discloses 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide compounds, their preparation methods, and applications, belonging to the field of pharmaceutical technology. Specifically, the general structural formula of the 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide compounds or their pharmaceutically acceptable salts is shown in Formula I, where R1 is defined in the claims and specification. The 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide compounds or their pharmaceutically acceptable salts provided by this invention, as inhibitors of vascular endothelial growth factor receptor 2 (VEGFR-2) kinase and epidermal growth factor receptor (EGFR) kinase, can be used to prepare drugs for the treatment or prevention of tumors related to VEGFR-2 kinase and EGFR kinase, demonstrating good application value and promising development prospects.

The application discloses a kind of high anti-fatigue recyclable epoxidized natural rubber based on double dynamic network and a preparation method thereof, belong to high polymer material and rubber modification technical field.The method first synthesizes precursor monomer containing end double bond and epoxy group, and then activates elemental sulfur to occur ring-opening reaction using activator, to prepare multifunctional crosslinking agent containing dynamic polysulfide bond, hydroxyl and end double bond;Subsequently, the crosslinking agent is mixed with epoxidized natural rubber and compounding agent, and a double dynamic network coordinated by dynamic polysulfide bond and reversible hydrogen bond is constructed in situ by high-temperature hot pressing.The application adopts filler-free strategy, and uses the macroscopic multiscale sacrificial network formed by hydrogen bond and polysulfide bond to achieve high strength and toughness, effectively passivate crack, and give the material extremely high fatigue resistance performance.Meanwhile, the material has excellent solid-state recyclable performance, the preparation route is simple, compatible with traditional rubber processing equipment, and has broad industrial application prospect.