103results about How to "Short preparation route" patented technology

The invention discloses polyimide foam and a preparation method thereof. Aromatic dianhydride and/or aromatic acid ester, alcohol with low molecular, a catalyst and a surface active agent are mixed proportionally in a polar solvent and react so as to form foam precursor solution. The foam precursor solution and isocyanate react in a mould and freely foam into a foam intermediate. The intermediate is solidified by microwave radiation or/and oven heating to obtain solid polyimide foam. The preparation process has short path, simple technology, good stability for storage of the foam precursor solution, adaptation to processing technologies of pouring, spray coating, extrusion, and the like, no occurrence of defects of cracked foam, foam combination, subsidence and incomplete amination, low preparation cost as well as uniform hold diameter and stable performance of the solid polyimide form, and is convenient for popularization and application.

The invention discloses modified polyimide foam and a preparation method thereof. The preparation method comprises the following steps: aromatic dianhydride and/or aromatic acid ester, siloxane with active terminal group, low molecular alcohol, a catalyst and a surface active agent are mixed into a polar solvent according to proportion and react to form foaming precursor solution which reacts with isocyanate to form foaming intermediate solution; and the foaming intermediate solution carries out foaming freely in a mold and forms a modified foaming intermediate which is radiated by microwave or/and heated and cured in an oven, and then the solid polyimide foam is obtained. The method has short route of preparation process and simple technique; the foaming precursor solution has good stability of storage, is suitable for the processing techniques of casting, painting, extruding and the like, and the defects of broken foam, parallel foam, depression and incomplete imidizate of materials do not occur; the polyimide foam has even aperture, high stability, low rigidity, good flexibility and good processability; and the preparation cost is low, thus being convenient to promotion and application.

The invention discloses a preparation method of brivaracetam (formula IV). The preparation method comprises the following steps: carrying out ammonolysis on (R)-4-propyl-dihydrofuran-2-one and (S)-2-amino butyric acid as raw materials to obtain an intermediate II, then carrying out steps of esterification, chlorination and cyclization to obtain an intermediate III, and finally, carrying out an ammonolysis step to obtain the brivaracetam (IV), wherein the steps of esterification, chlorination and cyclization are operated in a combination mode. The preparation method provided by the invention ismild in condition, is simple and convenient to operate, has easily obtained raw materials, and is suitable for large-scale industrial production.

The invention discloses self-crosslinking type LED package adhesive resin and a preparing method thereof. According to the preparing method, 100-105 weight parts of phenyltrimethoxysilane, 100-120 weight parts of diphenyldimethoxysilane, 10-20 weight parts of methyl-vinyl-cyclosiloxane, 30-50 weight parts of disiloxane, 20-60 weight parts of distilled water, 100-200 weight parts of solvent and 0.03-0.05 weight part of catalyst are sequentially added to a container, constant-temperature stirring is conducted for 3-5 h at 60-80 DEG C, stirring reaction is conducted for 4-8 h after temperature is increased to 100-120 DEG C, the pH value of obtained reaction liquid is adjusted to be 7, then reduced pressure distillation is conducted so as to remove the solvent and residual water, and finally the self-crosslinking type LED package adhesive resin high in light transmittance and refraction index is obtained. The resin can achieve self-crosslinking curing reaction under a certain condition, and the thermal decomposition temperature of a cured product is quite high.

The invention belongs to the field of compound preparation, and specifically discloses a preparation method of an anti-tumor medicine chlorambucil. The preparation method comprises the steps of performing a Vilsmeier reaction on a raw material N,N-dihydroxyethylaniline and phosphorus oxychloride and DMF so as to prepare 4-[bi(2-chloroethyl)amino]benzaldehyde, then performing a witting reaction on4-[bi(2-chloroethyl)amino]benzaldehyde and methoxymethyl triphenylphosphonium chloride so as to prepare 4-[bi(2-chloroethyl)amino]-BETA-methoxystyrene, reacting under an acid condition so as to obtain4-[bi(2-chloroethyl)amino]phenylacetaldehyde, and finally, reacting with Meldrum's acid in triethylamine and formic acid systems so as to prepare a target product. The raw material N,N-dihydroxyethylaniline is cheap, has a wide source and is easy to obtain; the whole reaction process has high yield, production conditions are mild, the steps are short, and post treatment and purification are easyto operate, so that the preparation method is applicable to commercial large scale production, and meets the rapidly growing market demands.

The invention discloses resin for an UV-curing LED packaging adhesive and a preparation method. The resin is prepared from phenyl hydrogen-containing silicone oil and a urethane acrylate compound through reaction under the action of a platinum catalyst; the light transmittance of the resin ranges from 81% to 90%, the transmissivity of the resin at the room temperature ranges from 1.5011 to 1.5455, and the curing time of the resin under the UV light irradiation ranges from 10 s to 60 s. The resin for the UV-curing LED packaging adhesive has the characteristics of high light transmittance, high reflective index, UV-curing capability and the like, can be used in the LED packaging field, and can be used in the technical fields of industries such as instruments, meters, household appliances, machinery, automobiles, electric products and the like.

The invention discloses a preparation method of boric acid functional group resin, belongs to the field of resin, and aims to solve the technical problems of poor adsorption material selectivity, lowadsorption capacity, high price, lack of accurate regulation and control in the material modification process and difficulty in efficient introduction of specific boric acid functional groups in the existing extraction and separation process of polyhydric alcohols, polyhydric phenols, saccharides and other high-added-value derivatives. The method comprises the following steps: selecting an anilineboric acid monomer with higher reaction activity and aniline and benzylamine boronic acid pinacol ester monomers, and loading the monomers on a polystyrene resin skeleton through an efficient and mild nucleophilic substitution reaction or loading the monomers on a polyacrylic resin skeleton through a condensation reaction to prepare the boric acid functional group resin with high functional grouploading capacity and high selectivity. The method overcomes the defects of low boric acid functional group loading rate, poor stability, poor recyclability and the like of the existing material, canefficiently and mildly load the boric acid function based on the resin carrier, and can effectively enrich and separate the polyhydroxy compound with the cis-vicinal diol or m-diol structure.

The invention discloses UV (ultraviolet) cured LED packaging adhesive resin and a method for preparing the same. The method includes sequentially adding 100-105 parts of diethoxysilane, 10-20 parts of hydrogen-containing mixed rings, 30-50 parts of hydrogen-containing double-seal heads, 20-60 parts of distilled water, 100-200 parts of solvents and 0.03-0.05 part of catalysts into a container, carrying out constant-temperature reaction at the temperature of 60-90 DEG C, increasing the temperature until the temperature reaches 100-120 DEG C, carrying out constant-temperature reaction, treating reaction and carrying out post-treatment to obtain phenyl hydrogen-containing silicone oil; enabling the phenyl hydrogen-containing silicone oil and ethoxylation trimethylolpropane triacrylate to react to each other under the effect of the platinum catalysts to obtain the UV cured LED packaging adhesive resin. The UV cured LED packaging adhesive resin and the method have the advantages that the UV cured LED packaging adhesive resin is high in light transmittance, has a high refractive index and can be used in the field of LED packaging and the technical fields of industries of instruments, apparatuses, household appliances, machinery, automobiles, electronic and electrical appliances and the like.

The invention provides aqueous fluorine-containing resin which is characterized by comprising the following preparation raw materials in parts by weight: 30-60 parts of isophorone diisocyanate, 50-100parts of polyether polyol, 5-10 parts of dimethylolpropionic acid, 10-20 parts of a fluorine-containing chain extender, 5-10 parts of a neutralizing agent, 10-20 parts of ethanediamine and 230-460 parts of deionized water, wherein polyether polyol comprises one or a mixture of two of PTMG1000 and N210,and the neutralizing agent is triethylamine. A preparation method is mild in experiment conditions, simple to operate, and suitable for industrial production, and the aqueous fluorine-containing resin can be widely used for protecting airplanes, ships, buildings, traffic and various mechanical equipment.

The invention discloses a preparation method of a polysubstituted pyrroloquinoline derivate. The preparation method is characterized in that aminochalcone and aldehyde are condensed to obtain chalcone imine; the chalcone imine and glycinate imine are subjected to series cyclizing through Michael/Mannich and then are subjected to acidizing, and thus the polysubstituted pyrroloquinoline derivate containing four chiral centers, as shown in formula (I), can be generated based on high diastereoselectivity. The preparation method is on the basis of series reaction, and has the advantages that the environmental protection is achieved; the synthesizing steps are simple and convenient; the atom economy is ensured; the diastereoselectivity is high; in addition, the reaction conditions are mild; the substance is wide in applicable scope; the operation is simple and safe; the preparation method is applicable to industrial production.

The invention discloses a synthesis method of hexafluoroisobutene. The synthesis method comprises the following steps of 1, making heptafluoroisobutenyl methyl ether react with borohydride in an I type solvent, conducting filtering and rectification after the reaction finishes to obtain hexafluoroisobutenyl methyl ether; 2, making hexafluoroisobutenyl methyl ether obtained in the step 1 react with acid, and conducting rectification after the reaction finishes to obtain hexafluoroisobutyraldehyde; 3, under the action of a catalyst, leading hydrogen into hexafluoroisobutyraldehyde obtained in the step 2 for a reaction, and conducting filtering after the reaction finishes to obtain hexafluoroisobutanol; 4, making hexafluoroisobutanol obtained in the step 3 react with alkali in an II type solvent, and collecting and rectifying the reaction product to obtain the hexafluoroisobutene product. The synthesis method of hexafluoroisobutene has the advantages of being simple in technology, high in yield, easy to operate and low in cost.

The invention provides a macrocyclic amide metal complex and a preparation method and an application thereof. The metal complex has the structural formula represented by the formula I; the formula I is defined in the specification, wherein R is CH3 or F, M is one of Fe, Co, Mn or Cu, and M' is K, Na or Li. The invention also provides the method for preparing the metal complex, wherein the method comprises a first-stage reaction, a second-stage reaction and a third-stage reaction. The invention further provides the application of the metal complex, wherein the metal complex is applied in oxidation reaction of alcohols organic matters and aldehydes organic matters. The metal complex provided by the invention can be prepared by a variety of routes, the preparation process is short, operations are simple, sources of used raw materials are rich, properties are stable, a central metal does not belong to precious metals, is low in price and is non-toxic or is low in toxicity, and the complex has excellent application properties in the oxidation reaction.

The invention discloses high-viscosity self-crosslinking LED package gum resin and a preparation method thereof. The preparation method comprises the following steps: sequentially adding the following components in parts by weight into a container: 100-105 parts of phenyltrimethoxysilane, 100-120 parts of diphenyldimethoxysilane, 10-20 parts of hydrogenous annulus, 20-60 parts of distilled water, 30-50 parts of divinyl tetramethyl disiloxane, 100-200 parts of a solvent and 3-5 parts of a catalyst; heating to 40-60 DEG C, and stirring at a constant temperature for 4-8 hours; heating to 100-130 DEG C, and stirring and reacting at a constant temperature for 4-8 hours; rinsing the reaction liquid to be neutral by using distilled water; distilling at reduced pressure of -0.096MPa at 200 DEG C to remove the solvent and residual moisture so as to obtain the high-viscosity self-crosslinking LED package gum resin which has the characteristics of high light transmittance and high refractive index.

The invention belongs to the technical field of methods for preparing temsirolimus, and relates to a method for preparing temsirolimus. The method comprises the following steps of: 1) adding 2,2-bis(hydroxymethyl) propionic acid, organic alkali and chlorosilane into an organic solvent, and reacting to obtain a compound I; 2) dissolving the compound I and the alkali in the organic solvent, adding 2,4,6-trichlorobenzene formyl chloride, reacting, adding reaction liquid into an organic solvent of a compound A and 4-(N,N-dimethylamino) pyridine, and reacting to generate a compound B; and 3) reacting the compound B and acid to obtain the temsirolimus. Compared with the prior art, the method has the advantages of short preparation route, high yield, simplicity of operation and low cost, and is suitable for industrial production.

The invention discloses a tetrahydrofuran benzodihydropyran polycyclic compound shown as a formula (I). The tetrahydrofuran benzodihydropyran polycyclic compound is prepared by the following steps: performing 3+2 cycloaddition on isatin diazo, ortho-substituted benzaldehyde and nitrophenyl alkene under the catalysis of rhodium acetate to construct a multi-substituted tetrahydrofuran intermediate; adding a base and performing intramolecular Michael addition to further cyclize so as to synthesize the tetrahydrofuran benzodihydropyran polycyclic compound. The compound has excellent inhibitory activity on histone deacetylase.