11 results about "Mycophenolic acid" patented technology

Mycophenolic acid, (MPA) is a non-competitive reversible inhibitor of the inosine monophosphate dehydrogenase (IMPDH), a key rate-limiting enzyme in the de novo purine synthesis pathway and also called mycophenolate, is an immunosuppressant drug used to prevent rejection in organ transplantation. It was initially introduced as the prodrug mycophenolate mofetil (MMF, trade name CellCept) to improve oral bioavailability. More recently, the salt mycophenolate sodium (trade name Myfortic) has also been introduced. Enteric-coated mycophenolate sodium is an alternative MPA formulation. However, the kinetics of EC-MPS differ in that the drug is enteric coated, dissolves at pH levels of ≥ 5,with the goal of delaying the delivery of MPA until it reaches the small intestine...