33results about How to "Strong immunogen specificity" patented technology

The invention discloses a carbamazepine immunogen, a carbamazepine specific antibody directly obtained through the immunogen, a detection reagent containing the specific antibody and a method for detecting the content of the carbamazepine in samples to be tested. The immunodetection reagent and the detection method have the advantages that the carbamazepine immunogen is strong in specificity and high in immunogenicity; the prepared carbamazepine immunogen is strong in specificity and high in titer and has no cross reaction with 45 common drugs; the homogeneous enzyme immunodetection reagent containing the carbamazepine specific antibody can conveniently, fast and accurately determine the content of the carbamazepine in the samples and can measure a plurality of samples simultaneously on a full-automatic biochemical analyzer, so that high-throughput and fast measuring of the carbamazepine are achieved, the accuracy is high, the specificity is strong, the accuracy and the detection efficiency are greatly improved compared with the prior art, full automation in the detection process is achieved simultaneously, the requirements on detection staff is not high, and the immunodetection reagent and the detection method are easy to achieve, popularize and use.

The invention discloses a docetaxel immunogen, a synthetic method of the docetaxel immunogen, an anti-docetaxel antibody obtained by the immunogen, a detection reagent and a preparation method of the anti-docetaxel antibody. The docetaxel immunogen disclosed by the invention is synthesized by brand-new docetaxel derivatives and has the advantage of high immunogenicity, an anti-docetaxel specific antibody with high specificity and binding force can be obtained by induction, and any cross reaction with common 62 medicines is avoided. According to the docetaxel detection reagent prepared from the antibody, the content of docetaxel in a sample can be conveniently and accurately determined, and clinical individualized treatment is promoted. Compared with the method in the prior art, the detection reagent disclosed by the invention can realize high-flux and rapid detection on a fully automatic biochemical analyzer and has the advantages of simple and convenient operation, high sensitivity, high specificity, accurate result and the like, the detection cost of the docetaxel can be effectively reduced, and the detection reagent is suitable for large-scale clinical popularization and application.

The invention discloses a cyclosporin A immunogen and a synthesis method thereof, as well as an anti-cyclosporin A antibody obtained from the immunogen, a detection reagent and a preparation method of the cyclosporin A immunogen. The cyclosporin A immunogen prepared by the preparation method disclosed by the invention has high immunogenicity and can obtain the anti-cyclosporin A specific antibody which has high valence and no cross reaction with common 62 medicines by induction; and the cyclosporin A detection reagent prepared from the antibody can precisely and rapidly determine the content of cyclosporin in a sample. Compared with the existing detection reagent in the market, the detection reagent disclosed by the invention has the advantages of simplicity and convenience in operation, high sensitivity, strong specificity, accurate result and the like, can effectively reduce the detection cost of cyclosporin A and is conductive to clinical large-scale popularization and application.

The invention discloses an estriol homogeneous phase enzyme immunoassay reagent as well as a preparation method and a detection method thereof and belongs to the technical field of immunoassay reagents. An estriol immunogen prepared by the invention is high in immunogenicity, can be induced to obtain a high-titer anti-estriol specific antibody and does not have any cross reaction with 62 common drugs. The estriol immunoassay reagent prepared by the antibody is capable of accurately and rapidly determining the estriol content in biological samples such as urea, blood and the like. Compared with the existing assay reagents in the market as well as detection methods and preparation methods thereof, the detection reagent disclosed by the invention has the advantages of simplicity and convenience in operation, high sensitivity, high specificity, accurate result and the like, is capable of effectively reducing the estriol detection cost and is favorable for large-scale clinical popularization and application.

The invention discloses a derivative of 3-(3-hydroxylphenyl)-3-hydroxy-propionic acid (HPHPA), a homogeneous enzyme immunodetection reagent and a preparation method therefor and relates to the technical field of biological detection. An HPHPA immunogen with high immunogenicity and an antibody thereof are prepared by using the derivative of the HPHPA, and the antibody is high in specificity and high in potency and is free of any cross reaction with 92 kinds of common interfering substances; and the HPHPA homogeneous enzyme immunodetection reagent prepared by using the antibody can achieve high-flux and rapid detection on the HPHPA on a fully-automatic biochemical analyzer, the accuracy of detection is high, the specificity is high, and the efficiency of detection is remarkably increased.

The invention relates to an oestrone derivative for detecting oestrone content in a biological sample and a preparation method of the oestrone derivative. The structural formula of the oestrone derivative is shown as a formula (I). Oestrone immunogens with high immunogenicity and corresponding antibodies are prepared in succession by using the oestrone derivative. The oestrone immunogen is high inspecificity and high in immunogenicity, and the anti-oestrone specific antibody is high in specificity and high in titer, is capable of well recognizing and binding oestrone, and does not have any cross reaction with common 92 chaff interferents. The invention further discloses an oestrone enzyme-labeled conjugate, and an oestrone homogeneous enzyme immunoassay detection reagent is prepared by utilizing the anti-oestrone specific antibody and the oestrone enzyme-labeled conjugate. The reagent is capable of conveniently, rapidly, and accurately measuring the oestrone content in the biologicalsample, multiple samples are determined on a full-automatic biochemical analyzer, high throughput and rapid determination of the oestrone is realized, the accuracy is high, the specificity is high, and the accuracy and detection efficiency are greatly improved compared with the previous detection.

The invention discloses deoxy pyridinoline immunogen, an antibody, a detection reagent and a preparing method.The prepared deoxy pyridinoline immunogen is high in immunogenicity and capable of obtaining high-potency specific antibody resisting deoxy pyridinoline through induction and has no cross reaction with 62 common dugs; the deoxy pyridinoline detection reagent prepared from the antibody can accurately and fast determine the content of deoxy pyridinoline in urine and other biological biological samples.Compared with existing detection reagents in the market, the detection reagent has the advantages of being easy to operate, high in sensitivity and specificity, accurate in result, capable of effectively reducing detection cost of deoxy pyridinoline and beneficial for large-scale clinical utilization and popularization.

The invention provides a 5-hydroxyindole acetic acid determination reagent. The 5-hydroxyindole acetic acid determination reagent comprises a 5-hydroxyindole acetic acid specific antibody and an indicator reagent; the 5-hydroxyindole acetic acid specific antibody is a complete antibody molecule generated after an experimental animal is immunized by a 5-hydroxyindole acetic acid immunogen; the 5-hydroxyindole acetic acid immunogen has strong specificity and high immunogenicity, and the prepared anti-5-hydroxyindole acetic acid specific antibody has strong specificity and high titer, and has nocross reaction with common 62 medicines; and according to the invention, a plurality of samples can be simultaneously measured on a full-automatic biochemical analyzer, the high-flux rapid measurementof 5-hydroxyindole acetic acid is realized, the accuracy is high, the specificity is strong, the accuracy and the detection efficiency are greatly improved compared with the prior art, the full automation of the detection process is realized, the requirement on detection personnel is not high, and the 5-hydroxyindole acetic acid determination reagent is easy to realize, popularize and use.

The invention relates to a dipeptide derivative for detecting angiotensin I as well as a preparation method and application thereof. The dipeptide derivative is a leucine-histidine dipeptide derivative and a structural formula is shown as a formula (I) as follows: the formula (I) is shown in the description. According to the dipeptide derivative provided by the invention, the leucine-histidine dipeptide derivative, repeated tests are carried out and an immunogen and a corresponding antibody are prepared in a pioneering manner by selecting two amino acid residues at the tail end of carboxyl ofthe angiotensin I; the obtained antibody can be used for identifying and combining the angiotensin I and a plurality of samples can be simultaneously determined on a full-automatic biochemical analyzer, so that high-throughput and rapid determination of the angiotensin I is realized; the dipeptide derivative has high accuracy and strong specificity; the precision and the detection efficiency are greatly improved when being compared with previous precision and detection efficiency; meanwhile, full automation of a detection process is realized, requirements on inspectors are not high and the dipeptide derivative is easy to realize, popularize and apply.