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Use of 20(S)-protopanoxadiol derivatives and 20(S)-protopanaxatriol derivatives in preparation of antidepressant medicines

A technology of protopanaxadiol and protopanaxatriol, which can be used in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as undisclosed uses

Active Publication Date: 2013-07-24
SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent 200510016774.4 discloses the synthesis method of dammar-20S-24(S)-epoxy-3β, 12β, 25-triol and its application in the preparation and treatment of coronary heart disease, myocardial ischemia, ischemic shock, arrhythmia and Use in drugs for reperfusion injury, but does not disclose its use in the preparation of drugs for the treatment or prevention of depressive mental illness

Method used

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  • Use of 20(S)-protopanoxadiol derivatives and 20(S)-protopanaxatriol derivatives in preparation of antidepressant medicines
  • Use of 20(S)-protopanoxadiol derivatives and 20(S)-protopanaxatriol derivatives in preparation of antidepressant medicines
  • Use of 20(S)-protopanoxadiol derivatives and 20(S)-protopanaxatriol derivatives in preparation of antidepressant medicines

Examples

Experimental program
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Effect test

Embodiment 1

[0097] 10g Dama-20S-24(R)-epoxy-3β, 12β, 25-triol, add an appropriate amount of lactose, mix well, use 70% ethanol as a binder, granulate, and put into capsules to obtain capsules , each containing 20 (S)-protopanaxadiol derivatives 20mg.

Embodiment 2

[0099] 10g Dama-20S-24(S)-epoxy-3β, 6β, 12β, 25-tetraol, add an appropriate amount of lactose, mix well, use 70% ethanol as a binder, granulate, and put into capsules to get Capsules, each containing 20(S)-protopanaxadiol derivatives 20mg.

Embodiment 3

[0101] 10g Dama-20S-24(R)-epoxy-3β, 12β, 25-triol, add an appropriate amount of lactose, mix well, use 70% ethanol as a binder, granulate, dry, and add an appropriate amount of magnesium stearate , Tablet compression to obtain tablets, each tablet containing 50 mg of 20(S)-protopanaxadiol derivatives.

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Abstract

The invention relates to a new use of 20(S)-protopanoxadiol derivatives and 20(S)-protopanaxatriol derivatives, and mainly relates to a use in the preparation of medicines for treating or preventing depressive mental diseases. 20(S)-protopanoxadiol and 20(S)-protopanaxatriol are used as raw materials, and undergo oxidative cyclization to prepare dammara-20S-24(R)-epoxy-3beta,12beta,25-triol, dammara-20S-24(S)-epoxy-3beta,12beta,25-triol, dammara-20S-24(S)-epoxy-3beta,6beta,12beta,25-tetrol or dammara-20S-24(R)-epoxy-3beta,6beta,12beta,25-tetrol. Researches of pharmacological experiments show that dammara-20S-24(R / S)-epoxy-3beta,12beta,25-triol and dammara-20S-24(R / S)-epoxy-3beta,6beta,12beta,25-tetrol can obviously shorten the tail immobility time of mice in mouse tail suspension tests of a classic depression model, and can obviously shorten the swimming immobility time of the mice in mouse forced swimming model tests, so dammara-20S-24(R / S)-epoxy-3beta,12beta,25-triol and dammara-20S-24(R / S)-epoxy-3beta,6beta,12beta,25-tetraol have potential development values in the preparation of medicines for treating or preventing depressive mental diseases.

Description

technical field [0001] The present invention relates to new uses of 20(S)-protopanaxadiol derivatives and 20(S)-protopanaxatriol derivatives, in particular to their use in preparing medicines for treating or preventing depression-type mental diseases. Background technique [0002] Depression is a disease characterized by emotional depression as the main manifestation. In mental diseases, it belongs to the category of affective mental disorders. The manifestations of depression can be generally referred to as "three lows", that is, low mood, slow thinking and depression. The core symptoms are depression, and the psychological symptoms are anxiety, self-blame, delusions or hallucinations, decreased attention and memory, suicidal tendencies, etc.; fatigue, etc. Depression is a common and frequently-occurring disease that endangers human health. In my country, the incidence of affective psychosis is 0.76%. The incidence of depression is high, but its causes are still unclear....

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P25/24A61P25/18
Inventor 王记华卢寿福许长江张文静汪沁琳杨子荣
Owner SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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