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New application of traditional Chinese medicine composition in preparation of antidepressant drugs

A composition and technology of traditional Chinese medicine, which is applied in the field of new application of traditional Chinese medicine composition in the preparation of antidepressant drugs, which can solve the problems of complex ingredients and many flavors of prescriptions

Active Publication Date: 2019-04-02
TONGYAO PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned traditional Chinese medicine composition has a certain curative effect on depression, but the prescription has many medicinal flavors and complex ingredients

Method used

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  • New application of traditional Chinese medicine composition in preparation of antidepressant drugs
  • New application of traditional Chinese medicine composition in preparation of antidepressant drugs
  • New application of traditional Chinese medicine composition in preparation of antidepressant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Composition: Citrus aurantium 100g, Magnolia officinalis 80g, Coptidis 100g, Pinellia 60g, Dried ginger 40g, Malt 40g, Atractylodes macrocephala 60g, Poria cocos 40g, Codonopsis 50g, Licorice 40g.

[0034] Preparation method: take Citrus aurantium, Magnolia officinalis and Atractylodes macrocephala, add 10 times the amount of water, soak for 1 hour, steam distillation and extraction for 6 hours, collect volatile oil, water extract and medicinal residues respectively, dissolve with an equal amount of ethanol, and set aside; weigh β-cyclodextrin with 8 times the amount of volatile oil is made into a saturated aqueous solution at 45-55 ° C, and the volatile oil dissolved in ethanol is added while stirring, and continuously stirred at 45-55 ° C for 3 hours, refrigerated overnight, filtered, and aired Dry to get β-cyclodextrin inclusion compound of volatile oil, set aside. The distilled aqueous solution is collected in another container for later use; medicinal dregs and Copti...

Embodiment 2

[0035] Example 2 Effects on Cell Survival Rate of Corticosterone-Induced PC12 Nerve Cell Injury Model

[0036] 1 Experiment purpose

[0037] By intervening the PC12 nerve cell injury model induced by corticosterone, the recovery effect of the traditional Chinese medicine composition of the present invention on the nerve cell injury model was observed at different concentrations.

[0038] 2 Experimental materials and experimental equipment:

[0039] 2.1 Experimental reagents

[0040] PC12 cells (ATCC), imported fetal bovine serum (CLARK), imported horse serum (Life Technology), 96-well cell culture plate (NEST), MTT powder (Sigma), corticosterone (Sigma).

[0041] 2.2 Experimental drugs

[0042] Embodiment 1 Chinese medicine composition. Dissolve in DMSO respectively to configure 200mg / mL stock solution.

[0043] 2.3 Main experimental equipment, see Table 1.

[0044] Table 1 Experimental equipment

[0045]

[0046] 3 Experimental methods

[0047] 3.1 Experimental pri...

Embodiment 3

[0056] Example 3 Effects on Mitochondrial Membrane Potential of Corticosterone-Induced PC12 Nerve Cell Injury Model

[0057] 1 Experiment purpose

[0058] By intervening the PC12 nerve cell injury model induced by corticosterone, the recovery effect of the traditional Chinese medicine composition of the present invention on the mitochondrial membrane potential of the nerve cell injury model is observed.

[0059] 2 Experimental materials and experimental equipment:

[0060] 2.1 Experimental reagents

[0061] Mitochondrial membrane potential probe kit (C2006, Biyuntian).

[0062] 2.2 Experimental drugs

[0063] Example 1 Chinese medicine composition, dissolved in DMSO, and configured as a 200 mg / mL stock solution.

[0064] 2.3 The main experimental equipment is Cytation 5 cell phase system (Bio Tek).

[0065] 3 Experimental methods

[0066] 3.1 Experimental principle

[0067] The process of apoptosis is often accompanied by the disruption of mitochondrial transmembrane po...

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Abstract

The invention relates to the technical field of traditional Chinese medicine, and in particular, relates to an application of a traditional Chinese medicine composition in preparation of antidepressant drugs. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of fructus aurantii, 4-8 parts of white atractylodes rhizome, 4-8 parts of rhizoma pinellinae praeparata, 5-15 parts of rhizoma coptidis, 3-7 parts of codonopsis pilosula, 2-6 parts of liquorice, 2-6 parts of poria cocos, 4-12 parts of cortex magnoliae officinalis, 2-6parts of malt, and 2-6 parts of dry ginger. Experiments show that the traditional Chinese medicine composition can improve the cell survival rate of a corticosterone-induced PC12 nerve cell injury model, restore the mitochondrial membrane potential, inhibit the expression of apoptotic genes and / or promote apoptosis and inhibit the gene expression; the traditional Chinese medicine composition significantly reduces the tail suspension immobility time and forced swimming immobility time of mice, and increases the serum 5-hydroxytryptamine content; the depressive behavior of the mice is improved obviously, and the results show that the composition has remarkable curative effect on depression.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a new application of a traditional Chinese medicine composition in the preparation of antidepressants. Background technique [0002] Depression is a clinical syndrome characterized by low mood, reduced speech, slow behavior, and emotional disturbances such as guilt and self-blame. In recent years, with the changes in the working and living environment, people are under increasing pressure. How to prevent and improve depression has become a topic of concern. [0003] At present, western medicine mainly adopts antidepressants, tranquilizers, sleeping pills, antipsychotics and other drugs to treat depression, which have large toxic and side effects, strong dependence and high price. [0004] The prior art also discloses a variety of antidepressant Chinese medicine compositions, such as patent CN104173933 which discloses a Chinese medicine composition for treat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P25/24
CPCA61K36/076A61K36/284A61K36/344A61K36/484A61K36/575A61K36/718A61K36/752A61K36/8888A61K36/8998A61K36/9068A61K2236/331A61K2236/39A61P25/24A61K2300/00
Inventor 高嵩徐建唐晓桐田淋淋吴萍赵源慧徐云
Owner TONGYAO PHARMA GROUP CORP
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