The invention relates to the technical field of traditional Chinese medicine, and in particular, relates to an application of a traditional Chinese medicine composition in preparation of antidepressant drugs. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of fructus aurantii, 4-8 parts of white atractylodes rhizome, 4-8 parts of rhizoma pinellinae praeparata, 5-15 parts of rhizoma coptidis, 3-7 parts of codonopsis pilosula, 2-6 parts of liquorice, 2-6 parts of poria cocos, 4-12 parts of cortex magnoliae officinalis, 2-6parts of malt, and 2-6 parts of dry ginger. Experiments show that the traditional Chinese medicine composition can improve the cell survival rate of a corticosterone-induced PC12 nerve cell injury model, restore the mitochondrial membrane potential, inhibit the expression of apoptotic genes and/or promote apoptosis and inhibit the gene expression; the traditional Chinese medicine composition significantly reduces the tail suspension immobility time and forced swimming immobility time of mice, and increases the serum 5-hydroxytryptamine content; the depressive behavior of the mice is improved obviously, and the results show that the composition has remarkable curative effect on depression.