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Application of epimedium extractive in the preparation of medicine for preventing and treating depression

A technology of epimedium extract and depression, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the effects of wide distribution, large output, and reduced production costs

Inactive Publication Date: 2005-06-22
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Previously, there were no reports at home and abroad that Epimedium extract, Epimedium total flavonoids, and Icariin had antidepressant activity

Method used

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  • Application of epimedium extractive in the preparation of medicine for preventing and treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Effects of Epimedium total flavonoids (55% icariin content) on the behavioral indicators of the mouse tail suspension model

[0037] Animal model: mouse tail suspension model

[0038] Rationale: A major symptom of depression is a reduction in motivated behavior. In the tail-suspension experimental model, the tail-suspension mice struggled to overcome abnormal postures, which is the motivational behavior of the mice, but after a certain period of time, they appeared intermittently immobile, showing a "disappointed" state. The immobility referred to here reflects a state called "behavioral despair and variant" or "failure to adapt to stress". A state of unmotivated hopelessness. The mouse tail suspension behavior despair model is sensitive to most antidepressants, and the operation is simple and fast, so it is widely used in the screening of such drugs.

[0039] Experimental drug: fluoxetine hydrochloride (fluoxetine, Changzhou No. 4 Pharmaceutical Factory) ...

Embodiment 2

[0067] Embodiment 2: The influence of the total flavonoids of Epimedium (icariin content is 55%) on the behavioral indicators of the mouse forced swimming model

[0068] Animal model: mouse forced swimming model

[0069] Rationale: A major symptom of depression is a reduction in motivated behavior. In the forced swim model, mice are forced to swim in a confined space, and they first exhibit motivated behaviors of struggling and trying to escape, followed by a state of immobility known as "desperation." The immobility referred to here reflects a state called "behavioral despair and variant" or "failure to adapt to stress". A state of unmotivated hopelessness. The mouse forced-swimming behavior despair model is sensitive to most antidepressants, and the operation is simple and fast, so it is widely used in the screening of such drugs.

[0070] Experimental drug: with embodiment 1

[0071] Experimental animal: same as embodiment 1

[0072] experimental method:

[0073] 1) m...

Embodiment 3

[0089] Example 3: Effects of Epimedium total flavonoids (55% icariin content) on the activity of MAO enzymes (including MAO-A, MAO-B) in the brain of depression model mice

[0090] Principle: Research on the mechanism of antidepressant action in recent years has shown that the antidepressant effect of drugs is closely related to the functional state of monoamine neurons in organisms: by inhibiting the activity of monoamine oxidase, it can selectively inhibit the degradation of intersynaptic monoamine transmitters, Increase its concentration, thereby enhancing the function of monoamine neurons. Therefore, the activity of monoamine oxidase (MAO) is considered to be an important indicator of depression pathology. The present inventors examined the enzymatic activities of MAO-A and MAO-B in the brains of mice.

[0091] Experimental Materials and Instruments

[0092] Experimental material: fluoxetine hydrochloride (fluoxetine, Changzhou Fourth Pharmaceutical Factory)

[0093] Am...

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Abstract

The invention relates to the novel use of pharmaceutical preparations in the field of pharmacy, more specifically the use of barrenwort flavones and barrenwort glycosides monomers as active components in preparing medicament for preventing and treating suppression. Pharmaceutical test shows that, the barrenwort flavones and barrenwort glycosides monomer can appreciably shorten rat's tail suspension time and forced swimming standby time, reverse the decrease of mouse sucrose consumption caused by CMS, suppress animal brain monoamines oxidation enzyme an and B, thus achieving the purpose of suppression resistance.

Description

1. Technical field [0001] The invention relates to a new application of the epimedium extract, in particular to the application of the epimedium extract in the preparation of drugs for preventing and treating depression. 2. Background technology [0002] Depression refers to an affective disorder syndrome characterized by low mood. The main clinical manifestations are depressed mood, fatigue, anhedonia, thinking and movement retardation, accompanied by anxiety, sleep disturbance, loss of appetite, despair and suicidal delusions. Clinically, depression often coexists with other serious diseases such as heart disease, stroke, cancer, and immune diseases. The World Health Organization survey report on the prevalence of mental illness shows that depression has become a common disease that endangers human physical and mental health in modern society, and it is becoming more and more serious. [0003] Most of the commonly used antidepressant drugs in clinical practice are artifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P25/24
Inventor 孔令东潘颖钟海波
Owner NANJING UNIV
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