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New protopine alkaloid and preparing method and application thereof

A proto-opioid and alkaloid technology, applied in the field of phytochemistry, can solve problems such as reports and no chemical components, and achieve the effects of good purity, convenience for pharmacological and clinical research, and high yield

Active Publication Date: 2019-06-28
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, up to now, there is no report on the relevant chemical components in the research on the antidepressant effect of summer

Method used

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  • New protopine alkaloid and preparing method and application thereof
  • New protopine alkaloid and preparing method and application thereof
  • New protopine alkaloid and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method of a new original opioid alkaloid, the specific steps are as follows:

[0026] (1) Crush 10.0 kg of summer-free tubers to 40 mesh, place them in 90% ethanol, and soak them at room temperature for 12 hours; then heat and reflux to extract 3 times, each time for 5 hours, let stand and filter, combine the filtrates, and store them at low temperature Dry under reduced pressure until there is no alcohol smell to obtain the total extract of summer free (857.5 grams);

[0027] (2) Evenly suspend the total summer extract in 1.5% hydrochloric acid solution, let it stand for 28 hours, and filter to obtain the supernatant;

[0028] (3) Adjust the obtained supernatants with 1.8% ammonia water to two alkaline solutions with pH=9 and pH=11, respectively, and combine the two alkaline solutions to obtain a mixed solution; use petroleum ether, Chloroform and n-butanol were extracted, and then concentrated and dried to obtain petroleum ether fraction extract (38.7 g...

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Abstract

The invention relates to a new protopine alkaloid and a preparing method and application thereof, and belongs to the technical field of phytochemistry. The molecular formula of the new protopine alkaloid is C31H34N2O6, and the new protopine alkaloid is a new compound separated and extracted from active parts of rhizoma corydalis decumbentis; meanwhile, the new compound of the new protopine alkaloid has significant anti-depression activity, and an important theoretical foundation and an experiment basis are laid for China to develop anti-depression drugs with independent intellectual property from the rhizoma corydalis decumbentis.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to a new proto-opioid alkaloid and its preparation method and application. Background technique [0002] Xia Wu, also known as a golden pill, fairy in the cave, falling water drop, etc., is the tuber of the plant Corydalis decumbens of the genus Corydalis genus Corydalis in the family Poppyaceae. Because its above-ground part withers in early summer and is hard to find, it is named Xia Wu. None in summer, bitter in nature, slightly pungent, returns to Liver Meridian. In summer, it has the effects of promoting qi and relieving pain, promoting blood circulation and removing blood stasis. As a common folk herbal medicine, Xiawu is often used to treat high blood pressure, sequelae of poliomyelitis, sciatica, bruises and other diseases. It has pharmacological effects such as dilating blood vessels, directly relaxing smooth muscle, anti-platelet aggregation, and anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/056A61P25/24
Inventor 马勤阁魏荣锐杨明钟国跃
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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