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A compound with antidepressant activity and its preparation method and application

An antidepressant and compound technology, which is applied in the field of compounds with antidepressant activity and their preparation, can solve the problems of consuming a lot of time and energy, and achieve the effect of good antidepressant activity

Active Publication Date: 2017-10-13
NANHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For many years, researchers have tried to prepare a new compound with good antidepressant activity outside the existing morpholine compounds through various synthetic methods. However, there is no relationship between the antidepressant activity of morpholine compounds and their structures. The correlation law can be followed, and at the same time, the synthesis experiment and the antidepressant activity experiment screening need a lot of time and energy. Up to now, the industry is still working hard to develop new compounds with good antidepressant activity

Method used

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  • A compound with antidepressant activity and its preparation method and application
  • A compound with antidepressant activity and its preparation method and application
  • A compound with antidepressant activity and its preparation method and application

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Embodiment Construction

[0015] In order to facilitate the understanding of those skilled in the art, the present invention will be further described below in conjunction with specific examples, and the contents mentioned in the examples are not intended to limit the present invention.

[0016] 1. Preparation of new compounds:

[0017] Add 0.005mol 1-(p-trifluoromethylphenyl)-2-bromo-acetone and 10mL NMP (about 0.104mol) to a 50mL round bottom flask, stir to dissolve evenly, then add 0.02mol phenylglycinol to react During the reaction, heat and control the temperature at 50±3°C and use nitrogen protection; stop the reaction after 1h, then add 20mL of distilled water, stir for several minutes, filter and dry the obtained filter cake, and then recrystallize with ethanol , collect the precipitated crystals and vacuum-dry them to obtain an intermediate product; finally, place the intermediate product in a reaction vessel, dissolve it with anhydrous ether, and slowly pass dry HCl gas into it while stirring...

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Abstract

The invention provides a compound with anti-depression activity and a preparation method and application of the compound, and relates to the technical field of medicine and chemical engineering. The structural formula is as shown in the specification. The structure of the compound is different from that of an existing morpholine compound; and the compound has a bran-new molecular structure and also has good anti-depression activity.

Description

technical field [0001] The invention relates to the technical field of medicine and chemical industry, in particular to a compound with antidepressant activity and its preparation method and application. Background technique [0002] Depression is a kind of mental disease, which can lead to suicide in severe cases. It not only brings huge mental pressure to patients, but also adds a heavy burden to patients' families and society. The global economic loss caused by depression exceeds 2,000 yuan every year. One hundred million U.S. dollars. [0003] Traditional antidepressants have a slow onset of action and severe side effects, and the current clinical options for antidepressants are very limited. Clinically commonly used antidepressants containing morpholine ring structures include Moclobemide, Reboxetine, and Manifaxine. The above antidepressants have good clinical therapeutic effects and few side effects specialty. However, except for the common morpholine ring, the abo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D265/32A61P25/24
CPCC07D265/32
Inventor 肖新荣郑友霖郭倩唐小敏田芳杰罗甜
Owner NANHUA UNIV
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