Traditional Chinese medicine composition volatile oil and preparation method and application thereof

A technology of volatile oils and compositions, applied in the field of traditional Chinese medicine, can solve problems such as difficulties, few antidepressant Chinese patent medicines, lack of curative effect and significant adverse reactions, etc., to increase sugar water preference, shorten immobility time, and significantly resist experimental depression in mice Effect

Inactive Publication Date: 2014-12-31
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing synthetic antidepressants often have more adverse reactions in the clinical treatment of depression, and often cause drowsiness, dry mouth, blurred vision, constipation, rapid heartbeat, dysuria and postural Hypotension; occasionally severe cardiovascular side effects, urinary retention, and intestinal paralysis; overdose can cause acute poisoning and even death
Traditional Chinese medicine has accumulated rich clinical experience in the prevention and treatment of depression, but there are not many antidepressant Chinese patent medicines on the market at present, and there is still a lack of Chinese patent medicines for the treatment of depression with significant curative effect and small adverse reactions

Method used

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  • Traditional Chinese medicine composition volatile oil and preparation method and application thereof
  • Traditional Chinese medicine composition volatile oil and preparation method and application thereof
  • Traditional Chinese medicine composition volatile oil and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0023] The preparation of embodiment 1 dropping pill

[0024] Take each raw material by the following weight: Magnolia officinalis 300g, perilla leaf 200g;

[0025] After mixing the above medicines, soak them in 8 times the weight of water for 6 hours, then put them in a flask and count them with glass beads, shake and mix them, connect the volatile oil tester and the reflux condenser tube, add water from the upper end of the condenser tube to fill the volatile oil tester part of the scale, and overflow into the flask until. Put it in an electric heating mantle and heat it slowly to boiling, and keep boiling slightly for 5 hours, until the amount of oil no longer increases, stop heating, let it stand for a long time, separate, and collect a yellow, clear, and fragrant oily liquid, and use anhydrous Sodium sulfate dehydration, obtained volatile oil. Take an appropriate amount of polyethylene glycol base, heat until melted, then add the volatile oil of the traditional Chinese ...

Embodiment 2

[0026] The preparation of embodiment 2 emulsion

[0027] Take each raw material by the following weight: Magnolia officinalis 300g, perilla leaf 200g;

[0028] After mixing the above medicines, soak them in 8 times the weight of water for 6 hours, then put them in a flask and count them with glass beads, shake and mix them, connect the volatile oil tester and the reflux condenser tube, add water from the upper end of the condenser tube to fill the volatile oil tester part of the scale, and overflow into the flask until. Put it in an electric heating mantle and heat it slowly to boiling, and keep boiling slightly for 5 hours, until the amount of oil no longer increases, stop heating, let it stand for a long time, separate, and collect a yellow, clear, and fragrant oily liquid, and use anhydrous Sodium sulfate dehydration, obtained volatile oil. Take an appropriate amount of 0.3% sodium benzoate, a sweetener, and gum arabic, add the volatile oil of the traditional Chinese medi...

Embodiment 3

[0029] The preparation of embodiment 3 aerosol

[0030] Take each raw material by the following weight: Magnolia officinalis 300g, perilla leaf 200g;

[0031] After mixing the above medicines, soak them in 8 times the weight of water for 6 hours, then put them in a flask and count them with glass beads, shake and mix them, connect the volatile oil tester and the reflux condenser tube, add water from the upper end of the condenser tube to fill the volatile oil tester part of the scale, and overflow into the flask until. Put it in an electric heating mantle and heat it slowly to boiling, and keep boiling slightly for 5 hours, until the amount of oil no longer increases, stop heating, let it stand for a long time, separate, and collect a yellow, clear, and fragrant oily liquid, and use anhydrous Sodium sulfate dehydration, obtained volatile oil. The volatile oil of the traditional Chinese medicine composition is fixed to 1000ml with absolute ethanol, and then 300ml of 15% non-i...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and natural medicines, and particularly relates to traditional Chinese medicine composition volatile oil and a preparation method and application thereof. The traditional Chinese medicine composition volatile oil is characterized by comprising the following Chinese herbal medicines by weight: 15-60 parts of mangnolia officinalis and 10-40 parts of perilla leaf. The traditional Chinese medicine composition volatile oil can be prepared into an oral preparation, an inhalant or an externally used ointment by a conventional traditional Chinese medicine preparation method. The beneficial effects of the traditional Chinese medicine composition volatile oil are mainly reflected in that: the traditional Chinese medicine composition volatile oil drug can significantly shorten the forced swimming and tail suspension immobility time of behavioral despair model mice, significantly shorten immobility time in forced swimming test and tail suspension test of chronic stress depression model mice, and significantly increase syrup preference of the chronic stress depression model mice. The result of study shows that the traditional Chinese medicine composition volatile oil has the significant anti experimental depression effect in mice.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a volatile oil of a traditional Chinese medicine composition and a preparation method and application thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Depression is a common mental illness characterized by high prevalence, high relapse rate, high disability rate and high mortality rate. The specific manifestations are: long-lasting depressed mood, and this mood obviously exceeds the necessary limit, lack of self-confidence, feeling a significant decrease in physical energy, and not being able to experience joy in any interesting activities. Such disorders can also cause physical dysfunction in patients, such as sleep disturbance, localized body pain, or loss of appetite. The World Health Organization reports that more than 350 million people worldwide suffer from depression, across all age groups. Depression is the leading cause of di...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61P25/24
Inventor 傅强马世平马占强吉薇薇马春华
Owner CHINA PHARM UNIV
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