Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of coniferin to preparation of antidepressant drugs

An antidepressant, coniferin technology, applied in the field of medicine, to achieve the effect of expanding the scope of application, shortening forced swimming, and shortening the cumulative immobility time of tail suspension

Inactive Publication Date: 2019-03-15
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no application of coniferin in the preparation of antidepressant drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of coniferin to preparation of antidepressant drugs
  • Application of coniferin to preparation of antidepressant drugs
  • Application of coniferin to preparation of antidepressant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] [Example 1] Effect of coniferin on cumulative immobility time of mice forced to swim

[0026] Male ICR mice were used for 7 days to adapt to the new environment. Mice were divided into blank control group, coniferin group [7.5, 15, 30 mg / (kg d)], imipramine group [30 mg / (kg d)], levodopa group [60 mg / ( kg•d)] and galantamine group [1.5mg / (kg•d)], 12 rats in each group, administered orally at 10:00 am every day for 7 days. One hour after the last administration, a forced swimming test was performed. The test was carried out in two days: on the first day, the mice were pre-swimmed in deep water at 22±2°C for 15 minutes, and after 24 hours, they were forced to swim for 6 minutes under the same conditions, and the cumulative immobility time of swimming within 4 minutes after the statistics (i.e. the mouse stops struggling or the mouse is in a floating state, with slight movements of the limbs to keep the head above the water), the results are shown in figure 1 . The res...

Embodiment 2

[0027] [Example 2] Effect of coniferin on cumulative immobility time of tail suspension in mice

[0028] Male ICR mice were used for 7 days to adapt to the new environment. Mice were divided into blank control group, coniferin group [7.5, 15, 30 mg / (kg d)], imipramine group [30 mg / (kg d)], levodopa group [60 mg / ( kg•d)] and galantamine group [1.5mg / (kg•d)], 12 rats in each group, administered orally at 10:00 am every day for 7 days. 1 h after the last administration, the tail suspension test was performed. About 1 cm away from the tip of the tail of the mouse, stick it on the bracket of the tail suspension box (25×25×30 cm) with adhesive tape, so that the mouse is in an upside-down state, and the hanging time is 6 minutes. Immobility time (that is, the mouse stops struggling or does not have any activity), the results are shown in figure 2 . The results showed that the cumulative immobility time of the tail suspension of the mice after the action of positive drugs, conife...

Embodiment 3

[0029] [Example 3] Effect of coniferin on body weight of rats with chronic stress depression

[0030]SD rats, male, were used for 7 days to adapt to the new environment. Except for the animals in the blank control group, the animals in the other groups were given the following series of chronic stress stimuli: (1) Food deprivation for 24 hours; (2) Water deprivation for 24 hours; (3) Exposure to an empty bottle for 1 hour; (4) Cage tilted (45°) for 7 h; (5) lighting overnight; (6) dirty cage (add 200 mL water and 100 g sawdust to the cage) for 24 h; (7) forced swimming at 8 °C for 6 min; (8) body Limit 2 h; (9) Exposure to foreign objects (eg, a piece of plastic) for 24 h. The above stress stimuli were randomly scheduled to be completed within 1 week and repeated for at least 4 weeks. After the modeling is completed, the degree of depression of the model is evaluated through sugar water preference and body weight test. Rats were divided into blank control group, coniferin g...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of coniferin to the preparation of antidepressant drugs. Coniferin has obvious effect on treatment of depression. According to the application, coniferin is prepared into oral administration, percutaneous administration or parenteral administration used for treating depression.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to the medical application of coniferin, in particular to the application of coniferin in a medicine for effectively treating depression. Background technique [0002] Depression is a common mood disorder, with significant and persistent low mood as the main clinical feature, its prevalence is increasing globally, and it is expected to become the second largest disease after coronary heart disease by 2020. The incidence of depression in my country is about 4%. Depressed patients show inability to adapt to society, slow thinking, memory loss, etc. They are high-risk groups of suicide, self-mutilation, and self-abuse, which constitute a major social health crisis. Not only that, clinical studies have found that depression coexists with various diseases such as Parkinson's disease and diabetes, which brings serious neuropsychiatric burden to patients. Therefore, depression has become ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P25/24
CPCA61K31/7034A61P25/24
Inventor 颜露韦敏宋萍萍钱怡云郑生智
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com