Application of coniferin to preparation of antidepressant drugs

An antidepressant, coniferin technology, applied in the field of medicine, to achieve the effect of expanding the scope of application, shortening forced swimming, and shortening the cumulative immobility time of tail suspension

Inactive Publication Date: 2019-03-15
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no application of coniferin in the preparation of antidepressant drugs

Method used

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  • Application of coniferin to preparation of antidepressant drugs
  • Application of coniferin to preparation of antidepressant drugs
  • Application of coniferin to preparation of antidepressant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] [Example 1] Effect of coniferin on cumulative immobility time of mice forced to swim

[0026] Male ICR mice were used for 7 days to adapt to the new environment. Mice were divided into blank control group, coniferin group [7.5, 15, 30 mg / (kg d)], imipramine group [30 mg / (kg d)], levodopa group [60 mg / ( kg•d)] and galantamine group [1.5mg / (kg•d)], 12 rats in each group, administered orally at 10:00 am every day for 7 days. One hour after the last administration, a forced swimming test was performed. The test was carried out in two days: on the first day, the mice were pre-swimmed in deep water at 22±2°C for 15 minutes, and after 24 hours, they were forced to swim for 6 minutes under the same conditions, and the cumulative immobility time of swimming within 4 minutes after the statistics (i.e. the mouse stops struggling or the mouse is in a floating state, with slight movements of the limbs to keep the head above the water), the results are shown in figure 1 . The res...

Embodiment 2

[0027] [Example 2] Effect of coniferin on cumulative immobility time of tail suspension in mice

[0028] Male ICR mice were used for 7 days to adapt to the new environment. Mice were divided into blank control group, coniferin group [7.5, 15, 30 mg / (kg d)], imipramine group [30 mg / (kg d)], levodopa group [60 mg / ( kg•d)] and galantamine group [1.5mg / (kg•d)], 12 rats in each group, administered orally at 10:00 am every day for 7 days. 1 h after the last administration, the tail suspension test was performed. About 1 cm away from the tip of the tail of the mouse, stick it on the bracket of the tail suspension box (25×25×30 cm) with adhesive tape, so that the mouse is in an upside-down state, and the hanging time is 6 minutes. Immobility time (that is, the mouse stops struggling or does not have any activity), the results are shown in figure 2 . The results showed that the cumulative immobility time of the tail suspension of the mice after the action of positive drugs, conife...

Embodiment 3

[0029] [Example 3] Effect of coniferin on body weight of rats with chronic stress depression

[0030]SD rats, male, were used for 7 days to adapt to the new environment. Except for the animals in the blank control group, the animals in the other groups were given the following series of chronic stress stimuli: (1) Food deprivation for 24 hours; (2) Water deprivation for 24 hours; (3) Exposure to an empty bottle for 1 hour; (4) Cage tilted (45°) for 7 h; (5) lighting overnight; (6) dirty cage (add 200 mL water and 100 g sawdust to the cage) for 24 h; (7) forced swimming at 8 °C for 6 min; (8) body Limit 2 h; (9) Exposure to foreign objects (eg, a piece of plastic) for 24 h. The above stress stimuli were randomly scheduled to be completed within 1 week and repeated for at least 4 weeks. After the modeling is completed, the degree of depression of the model is evaluated through sugar water preference and body weight test. Rats were divided into blank control group, coniferin g...

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Abstract

The invention discloses application of coniferin to the preparation of antidepressant drugs. Coniferin has obvious effect on treatment of depression. According to the application, coniferin is prepared into oral administration, percutaneous administration or parenteral administration used for treating depression.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to the medical application of coniferin, in particular to the application of coniferin in a medicine for effectively treating depression. Background technique [0002] Depression is a common mood disorder, with significant and persistent low mood as the main clinical feature, its prevalence is increasing globally, and it is expected to become the second largest disease after coronary heart disease by 2020. The incidence of depression in my country is about 4%. Depressed patients show inability to adapt to society, slow thinking, memory loss, etc. They are high-risk groups of suicide, self-mutilation, and self-abuse, which constitute a major social health crisis. Not only that, clinical studies have found that depression coexists with various diseases such as Parkinson's disease and diabetes, which brings serious neuropsychiatric burden to patients. Therefore, depression has become ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P25/24
CPCA61K31/7034A61P25/24
Inventor 颜露韦敏宋萍萍钱怡云郑生智
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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