Application of Kaurenoic Acid in the Preparation of Antidepressant Drugs
A kaurenoic acid, anti-depressant technology, applied in the direction of drug combination, anhydride/acid/halide active ingredients, nervous system diseases, etc., to shorten the cumulative immobility time of tail suspension, significant antidepressant effect, shorten forced swimming Effect
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Embodiment 1
[0025] [Example 1] Effect of Kaurenoic Acid on Accumulated Immobility Time of Mice in Forced Swimming
[0026] Male ICR mice were used for 7 days to adapt to the new environment. Mice were divided into blank control group, kaurenoic acid group [7.5, 15, 30 mg / (kg·d)], imipramine group [30 mg / (kg·d)], levodopa group [60 mg / (kg·d)] and galantamine group [1.5 mg / (kg·d)], 12 rats in each group, were administered orally at 10:00 am every day for 7 days. One hour after the last administration, a forced swimming test was performed. The test was carried out in two days: on the first day, the mice were pre-swimmed in deep water at 22±2°C for 15 minutes, and after 24 hours, they were forced to swim for 6 minutes under the same conditions, and the cumulative immobility time of swimming within 4 minutes after the statistics (i.e. the mouse stops struggling or the mouse is in a floating state, with slight movements of the limbs to keep the head above the water), the results are shown in...
Embodiment 2
[0027] [Example 2] Effect of Kaurenoic Acid on Cumulative Immobility Time of Mouse Tail Suspension
[0028] Male ICR mice were used for 7 days to adapt to the new environment. Mice were divided into blank control group, kaurenoic acid group [7.5, 15, 30 mg / (kg·d)], imipramine group [30 mg / (kg·d)], levodopa group [60 mg / (kg·d)] and galantamine group [1.5 mg / (kg·d)], 12 rats in each group, were administered orally at 10:00 am every day for 7 days. 1 h after the last administration, the tail suspension test was performed. About 1 cm away from the tip of the tail of the mouse, stick it on the bracket of the tail suspension box (25×25×30 cm) with adhesive tape, so that the mouse is in an upside-down state, and the hanging time is 6 minutes. Immobility time (that is, the mouse stops struggling or does not have any activity), the results are shown in figure 2 . The results showed that after the positive drugs, kaurenoic acid [7.5, 15, 30 mg / (kg d)], levodopa, and galantamine, t...
Embodiment 3
[0029] [Example 3] Effect of Kaurenoic Acid on Body Weight of Chronic Stress Depressed Rats
[0030]SD rats, male, were used for 7 days to adapt to the new environment. Except for the animals in the blank control group, the animals in the other groups were given the following series of chronic stress stimuli: (1) Food deprivation for 24 hours; (2) Water deprivation for 24 hours; (3) Exposure to an empty bottle for 1 hour; (4) Cage tilted (45°) for 7 h; (5) lighting overnight; (6) dirty cage (add 200 mL water and 100 g sawdust to the cage) for 24 h; (7) forced swimming at 8 °C for 6 min; (8) body Limit 2 h; (9) Exposure to foreign objects (eg, a piece of plastic) for 24 h. The above stress stimuli were randomly scheduled to be completed within 1 week and repeated for at least 4 weeks. After the modeling is completed, the degree of depression of the model is evaluated through sugar water preference and body weight test. Rats were divided into blank control group, kaurenoic ac...
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