13 results about "Anti-Anxiety Effect" patented technology

The invention belongs to the technical field of nerve drugs, and particularly relates to application of an orexin receptor 1 antagonist and / or an orexin receptor 2 antagonist in preparation of drugs for treating insomnia or anxiety, and the compound is a compound and salt shown in the following structure. In in-vivo experiments, the traditional Chinese medicine composition shows a more excellent anti-insomnia effect and shows a good anti-anxiety effect. In addition, the structure also has better stability and pharmacokinetic characteristics, such as higher exposure and half-life period.

The application discloses application of prostaglandin A2 in preparation of a medicine for treating anxiety and the medicine, belongs to the technical field of biological medicine, and particularly relates to application of prostaglandin A2 in preparation of a medicine for treating anxiety. The application proves that prostaglandin A2 can exert a multi-target anti-anxiety effect from the aspects of overall behavior, cell function, neural loop structure and molecular level through a chronic restraint stress (CRS) mouse model, a PC12 cell model damaged by corticosterone (CORT) and multi-level molecular, loop and behavior analysis. Prostaglandin A2 can treat anxiety by improving anxiety-like behavior and reversing behavior phenotype damage.

This invention discloses a plant essential oil spray with anti-anxiety and antidepressant effects and its preparation process, available in daytime and nighttime versions. The plant essential oil mixture is prepared by coupled flash extraction with anhydrous ethanol and 1-octyl-3-methylimidazolium bromide, followed by microfiltration-nanofiltration and vacuum distillation. The excipients and essential oils are then mixed and bottled into spray bottles equipped with an automatic spraying device to obtain the daytime and nighttime plant essential oil sprays. The daytime version stimulates the autonomic nervous system, reduces mental fatigue, improves cognitive mood, and exerts an anti-anxiety effect during the day; the nighttime version regulates neurotransmitter levels, significantly calms and soothes the mind, and adapts to the differences in human mood and nervous state between day and night. This invention features high extraction efficiency, stable essential oil quality, and the product possesses both anti-anxiety and antidepressant effects. It is convenient to use, highly safe, and suitable for daily mood regulation, psychological stress relief, and intervention for anxiety and depression tendencies.

This invention discloses the application of prostaglandin A2 in the preparation of drugs for treating anxiety disorders and the related pharmaceutical formulation. It belongs to the field of biomedical technology, and specifically relates to the application of prostaglandin A2 in the preparation of drugs for treating anxiety disorders. Through chronic restraint stress (CRS) mouse models, corticosterone-induced (CORT)-damaged PC12 cell models, and multi-level molecular, circuit, and behavioral analyses, this invention demonstrates that prostaglandin A2 can exert multi-target anti-anxiety effects at the levels of overall behavior, cellular function, neural circuit structure, and molecularity. Prostaglandin A2 can treat anxiety disorders by improving anxiety-like behaviors and reversing behavioral phenotypic damage.

The invention discloses preparation and application of a twin drug with synergistic anti-depression and anti-anxiety effects, the twin drug is formed by connecting a drug A and a drug B through a covalent bond, the drug A is desmethylvenlafaxine, and the drug B is a non-steroidal anti-inflammatory drug. On one hand, the twin drug increases the content of neurotransmitters (5-hydroxytryptamine and noradrenaline) in hippocampus, on the other hand, the twin drug plays a synergistic anti-depression and anti-anxiety role through playing anti-inflammatory, anti-oxidation, neuronal cell protection and other roles, and the anti-depression and anti-anxiety effects of the twin drug are superior to those of any single drug or a composition of drugs A and B. The twin drug has the potential of treating depression, anxiety, neuroinflammation and nervous system related diseases; meanwhile, the medicine taking compliance of a patient can be improved.

The invention provides application of agomelatine in preparation of a medicine for treating sicca syndrome, and relates to the technical field of biomedicine, agomelatine is a novel anti-depression medicine, and the main action mechanism of agomelatine is that anti-depression and anti-anxiety effects are achieved by activating melatonin receptors (MT1 and MT2) and antagonizing a 5-HT2c receptor. According to the application, an 8w-old NOD mouse is selected as a sicca syndrome model mouse, and meanwhile, an ICR mouse is selected as a normal mouse of the same control. NOD mice are randomly divided into a blank control group, a hydroxychloroquine (HCQ) treatment group (50 mg / kg), a melatonin (MLT) treatment group (15 mg / kg) and an agomelatine (AGO) treatment group (50 mg / kg). And observing the disease degree of the sicca syndrome mouse after 4W treatment. A specific verification experiment proves that the agomelatine in the application can be used for remarkably improving the sicca syndrome.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a medicine for improving or treating mixed anxiety and depressive disorder and application thereof. The medicine is prepared from the following raw materials in parts by weight: 10-30 parts of codonopsis pilosula, 10-30 parts of moutan bark, 10-30 parts of liquorice, 10-30 parts of radix angelicae pubescentis, 10-30 parts of radix bupleuri, 10-30 parts of honey-fried licorice root, 10-30 parts of radix paeoniae alba, 10-30 parts of radix puerariae, 10-20 parts of radix saposhnikoviae, 3-20 parts of rhizoma cimicifugae, 10-20 parts of notopterygium root, 10-30 parts of radix rehmanniae recen, 10-30 parts of poria cocos, 10-30 parts of rhizoma acori graminei and 10-30 parts of polygala tenuifolia. The medicine for improving or treating mixed anxiety and depressive disorder, provided by the invention, treats anxiety and depression after stress by a treatment method mainly comprising invigorating spleen and supplementing qi, and dispersing and clearing fire, not only can improve anxiety and depressive mental symptoms of patients, but also can improve somatochemical symptoms of digestive systems and skeletal muscle systems, and can improve the curative effect of the patients. By reducing blood sugar and serum cortisol rise caused by stress, the anti-anxiety effect can be continuously achieved for 14 days after drug withdrawal, the treatment effect is good, and safety and reliability are achieved.

The invention relates to the technical field of microorganisms, in particular to a probiotic composition for relieving anxiety and application, and the probiotic composition comprises lactobacillus rhamnosus LGD-0817, lactobacillus rhamnosus LDL-1708, lactobacillus plantarum LEP-1208 and lactobacillus plantarum MCA-3066. The probiotic composition is used for fermenting the traditional Chinese medicine composition, the obtained traditional Chinese medicine fermentation composition contains probiotics and traditional Chinese medicine fermentation liquor, the probiotics and the traditional Chinese medicine fermentation liquor can effectively achieve a synergistic effect, and the medicine effect of improving and treating depression is achieved; the traditional Chinese medicine fermentation composition plays a role through a plurality of ways, on one hand, the CRF content of hypothalamus and the ACTH content secreted by pituitary are reduced, so that the level of serum corticosterone is regulated and controlled, and the anti-depression and anti-anxiety effects are achieved; on the other hand, the 5-HT level of the central nervous system can be increased, the anti-depression effect is achieved, and it is prompted that the compound has the prospect of developing new anti-depression and anti-anxiety drugs and has clinical practical value.

A traditional Chinese medicine compound composition with anti-anxiety effect and its preparation method and application are disclosed. The traditional Chinese medicine compound composition with anti-anxiety effect is prepared by compounding the Paeoniae Radix Alba extract, the Gardeniae Fructus extract, the Albiziae Flos extract and the Moutan Cortex extract. The traditional Chinese medicine compound composition has no toxic side effects and has remarkable treatment effect, and can be used as a dietary supplement or a health-care food ingredient to prevent and treat anxiety disorder, and promote mental health. It can be seen that the traditional Chinese medicine compound composition is suitable for promotion and application.

The application discloses a brain peptide enzymolysis active peptide and a preparation method and application thereof, and belongs to the technical field of active peptide preparation. The brain peptide enzymolysis active peptide VVAVP is successfully prepared by adopting a specific preparation method to perform enzymolysis and purification on a pig brain extract, and the enzymolysis yield and enzymolysis purity are significantly improved by adopting the preparation method. In addition, the efficacy of the prepared short peptide is verified, and the experimental results show that the short peptide VVAVP can play an anti-anxiety role on an anxiety mouse model, and the treatment effect is equivalent to that of a positive control group, so that it is indicated that the active peptide VVAVP has certain emotion regulation ability.

This invention belongs to the field of biomedical technology, specifically relating to a novel use of Yueju tablets in anxiolytic activity. Specifically, the Yueju tablets provided by this invention exhibited significant anxiolytic activity in a mouse acute anxiety model experiment, showing superior efficacy compared to the positive control drug fluoxetine in some models, and can be used to develop anxiolytic drugs. Preliminary mechanistic studies have shown that it exerts a significant anxiolytic effect by reducing neuroinflammation and protecting neuronal integrity.

The invention discloses a brain peptide enzymolysis active peptide as well as a preparation method and application thereof. Belongs to the technical field of active peptide preparation. The specific preparation method is adopted, the pig brain extract is subjected to enzymolysis and purification, the brain peptide enzymolysis active peptide VVAVP is successfully prepared, and the enzymolysis yield and the enzymolysis purity are remarkably improved by adopting the preparation method. In addition, efficacy verification is carried out on the prepared oligopeptide, and experimental results show that the oligopeptide VVAVP can play a certain anti-anxiety role on an anxiety mouse model, the treatment effect of the oligopeptide VVAVP is equivalent to that of a positive control group, and it is indicated that the active peptide VVAVP has a certain emotion regulation ability.

The application belongs to the technical field of biological medicine, and specifically discloses application of benserazide hydrochloride in preparation of anxiolytic drugs. The application first finds that benserazide hydrochloride plays an anxiolytic role by regulating the kynurenine metabolic pathway. Animal experiments prove that benserazide hydrochloride can promote the generation of kynurenine and its downstream metabolite 3-hydroxyanthranilic acid, and maintain the stable level of 3-hydroxykynurenine, thereby improving the function of the metabolic pathway and restoring the nervous system homeostasis. Behavioral experiments show that benserazide hydrochloride can increase the exploration behavior of zebrafish and reduce the avoidance behavior, and meanwhile, does not cause inhibition of motor function or sedative effect, and shows good safety and selectivity. The application provides a theoretical basis and a new drug source for the prevention and / or treatment of anxiety.