4 results about "Anti-Anxiety Effect" patented technology

This invention discloses a plant essential oil spray with anti-anxiety and antidepressant effects and its preparation process, available in daytime and nighttime versions. The plant essential oil mixture is prepared by coupled flash extraction with anhydrous ethanol and 1-octyl-3-methylimidazolium bromide, followed by microfiltration-nanofiltration and vacuum distillation. The excipients and essential oils are then mixed and bottled into spray bottles equipped with an automatic spraying device to obtain the daytime and nighttime plant essential oil sprays. The daytime version stimulates the autonomic nervous system, reduces mental fatigue, improves cognitive mood, and exerts an anti-anxiety effect during the day; the nighttime version regulates neurotransmitter levels, significantly calms and soothes the mind, and adapts to the differences in human mood and nervous state between day and night. This invention features high extraction efficiency, stable essential oil quality, and the product possesses both anti-anxiety and antidepressant effects. It is convenient to use, highly safe, and suitable for daily mood regulation, psychological stress relief, and intervention for anxiety and depression tendencies.

This invention discloses the application of prostaglandin A2 in the preparation of drugs for treating anxiety disorders and the related pharmaceutical formulation. It belongs to the field of biomedical technology, and specifically relates to the application of prostaglandin A2 in the preparation of drugs for treating anxiety disorders. Through chronic restraint stress (CRS) mouse models, corticosterone-induced (CORT)-damaged PC12 cell models, and multi-level molecular, circuit, and behavioral analyses, this invention demonstrates that prostaglandin A2 can exert multi-target anti-anxiety effects at the levels of overall behavior, cellular function, neural circuit structure, and molecularity. Prostaglandin A2 can treat anxiety disorders by improving anxiety-like behaviors and reversing behavioral phenotypic damage.

This invention belongs to the field of biomedical technology, specifically relating to a novel use of Yueju tablets in anxiolytic activity. Specifically, the Yueju tablets provided by this invention exhibited significant anxiolytic activity in a mouse acute anxiety model experiment, showing superior efficacy compared to the positive control drug fluoxetine in some models, and can be used to develop anxiolytic drugs. Preliminary mechanistic studies have shown that it exerts a significant anxiolytic effect by reducing neuroinflammation and protecting neuronal integrity.

The application belongs to the technical field of biological medicine, and specifically discloses application of benserazide hydrochloride in preparation of anxiolytic drugs. The application first finds that benserazide hydrochloride plays an anxiolytic role by regulating the kynurenine metabolic pathway. Animal experiments prove that benserazide hydrochloride can promote the generation of kynurenine and its downstream metabolite 3-hydroxyanthranilic acid, and maintain the stable level of 3-hydroxykynurenine, thereby improving the function of the metabolic pathway and restoring the nervous system homeostasis. Behavioral experiments show that benserazide hydrochloride can increase the exploration behavior of zebrafish and reduce the avoidance behavior, and meanwhile, does not cause inhibition of motor function or sedative effect, and shows good safety and selectivity. The application provides a theoretical basis and a new drug source for the prevention and / or treatment of anxiety.