90 results about "Anti-Anxiety Effect" patented technology

Compositions based on hydrogenated pyrido[4,3-b]indoles (variants) of formula (1) or formula (2): are provided, as are methods and kits using those compositions for the treatment of anxiety or mood disorders characterized by stresses, anxiety, neuroses, obsessive fears and their consequences.

An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.

The invention discloses a Chinese medicinal composition with the effects of antidepressant and anti-anxiety, and belongs to the field of Chinese traditional medicines. The Chinese medicinal composition comprises (by weight parts) radix bupleuri 6-15, cape jasmine fruit 5-15 or paeonia suffruticosa bark 5-20, and angelica sinensis 3-15 or ligusticum chuanxiong 3-15; and can be prepared into any conventional oral preparations. Different ministerial drugs and adjuvant drugs are added according to different subjects to better exert therapeutic effect. The inventive composition has the effects of antidepressant and anti-anxiety; and can be used for relieving depression and anxiety with the advantages of definite therapeutic effect and rapid drug effect. The inventive composition can also be used for relieving headache, palpitation, insomnia and melancholia.

The present invention provides novel compositions in the form of a powder, capsule, liquid or lozenge, and methods for administering said novel compositions to assist the body in its ability to maintain a reasonable homeostatic mechanism for compensating for chronic internal acidity. The composition may contain several active ingredients, such as potassium bicarbonate, citric acid, calcium citrate, magnesium citrate, glycine, and licorice. The composition may also contain other inactive excipients, such as hypoallergenic rice, flour, glycerine, tangerine oil and gelatin. Following oral administration, the composition is rapidly broken down and absorbed into the systemic circulation. Upon absorption, the individual components are able to assist the physiological acid-alkaline buffer systems, promote anti-anxiety effects, and decrease inflammation in the digestive system.

The present invention provides the extraction of wild jujube seed oil, the preparation of soft capsule and the function on central nervous system. The extraction of wild jujube seed oil includes squeezing wild jujube seed in squeezer to obtain dregs and coarse oil; mixing the dregs and petroleum ether to obtain refined oil after recovering petroleum ether; dissolving the coarse oil and petroleum ether to obtain refined oil after recovering petroleum ether; merging refined oil, heating in evaporating pot to eliminate residual solvent and water and to obtain wild jujube seed oil. The preparation of soft wild jujube seed oil capsule includes soaking gelatin, heating in water bath, adding glycerin and Nipagin A, and filtering to obtain gelatin liquid; preparing gelatin plate with the gelatin liquid; sandwiching wild jujube seed oil with two gelatin plates and pressing with steel mold. Research shows that wild jujube seed oil has tranquilizing, hypnotic, memory-promoting and anxiety resisting effects, and may be used in treating neurosis and insomnia.

The invention discloses a pharmaceutical composition with the effects of hypnosis, anti-depression and anti-anxiety, and belongs to the traditional Chinese medicine field. The pharmaceutical raw materials of the pharmaceutical composition are: 6 to 40 parts by weight of Szechuan lovage rhizome and 10 to 40 parts by weight of pinellia tuber which are taken as monarch drugs; and 3 to 20 parts by weight of cape jasmine fruit or 1 to 15 parts by weight of golden thread which are taken as ministcrial drugs. The pharmaceutical composition can be prepared into any common preparation form for internal usage. The different adjuvant drugs or guide drugs can be added on the basis of the monarch drugs and the ministcrial drugs according to the different individual differences, so as to play the better efficacy. The pharmaceutical composition of the invention has the effects of hypnosis, anti-depression and anti-anxiety, the efficacy for the treatment of insomnia, depression and anxiety disorder is exact, the onset of action is fast, and the pharmaceutical composition can also be used for the treatment of insomnia, melancholia, headache, palpitation and other diseases of the traditional Chinese medicine.

The invention provides to an anti-anxiety medicine by using a rheum officinate root extract as an active ingredient. The anti-anxiety medicine uses the rheum officinate root extract as the active ingredient and can be made into various oral administration formulations such as tablet, granules, capsule, oral liquor, etc.; other components and supplementary materials can be added to form a compound preparation; and the anti-anxiety medicine has evident anti-anxiety effect and can be used for health and treatment of anxiety disorder. Moreover, the invention further provides health food prepared from the rheum officinate root extract and food additives, and preparation methods of the medicine and the food.

The invention discloses an application of a P2X2 receptor agonist or a P2X2 receptor opening agent in preparation of anti-depression or anti-anxiety drugs. According to the present invention, experiment research results confirm that: the P2X2 receptor agonist or the P2X2 receptor opening agent has an anti-depression and / or anti-anxiety effect, such that the P2X2 receptor agonist or the P2X2 receptor opening agent can be used for preparing anti-depression or anti-anxiety drugs, and can be adopted to screen prevention and treatment target points of anti-depression and / or anti-anxiety drugs and screen early stage pre-warning and clinical diagnostic reagents of depression and / or anxiety so as to provide broad application prospects.

The invention discloses a traditional Chinese medicine composition with functions of treating insomnia, improving senile dementia, enhancing learning and memory abilities, resisting to depression and anxiety and soothing the nerves and benefitting intelligence.The traditional Chinese medicine composition comprises Rhizoma Gastrodiae, Radix Paeoniae Alba, Radix Acanthopanacis Senticosi and Semen Ziziphi Spinosae.The traditional Chinese medicine composition can be prepared into dosage forms acceptable clinically or pharmaceutically.Animal experiments show that the traditional Chinese medicine composition can improve the sleeping function and senile dementia and enhance learning and memory abilities, and has the anti-depression and anti-anxiety effects.

The invention discloses an anti-anxiety pharmaceutical composition which is prepared from the following raw medicines: jatamans valeriana rhizome, cortex albiziae, spina date seed and juncus communis. By using the pharmaceutical composition disclosed by the invention for carrying out a mouse elevated plus-maze test, a light and dark box test, an independent activity test, a nikethamide-induced mouse convulsion test, a rat elevated plus-maze test, a rat Vogel test, a rat independent drinking test and a pain threshold test, the test results show that the pharmaceutical composition and capsules disclosed by the invention have obvious anti-anxiety effects and have no calming effects or side effects.

This invention provides a pharmaceutical and functional food which are made of a safe food ingredient or nutrient which has been used for a long period of time, and which have tranquilizing effect such as anti-anxiety effect, anti-depression effect, and anti-stress effect. The tranquilizer of the invention contains vitamin K as an active ingredient. Vitamin K is preferably menaquinone-4 and / or menaquinone-7. This invention also provides a supplement, health food or functional food for tranquilizing purpose that contains vitamin K as an active ingredient.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to preparation of a cannabidiol nasal preparation composition for treating post-traumatic stress disorder, and temperature sensitive gel, ion sensitive gel, cubic liquid crystals, and the like are included; the cannabidiol nasal preparation composition has high adhesion in a nasal cavity, residence time isprolonged in the nasal cavity, bioavailability is improved beneficially to exert the pharmacological effect, and brain targeting is achieved; at the same time, the preparation process is simple, stability is high, and compliance of the patient is good; and pharmacodynamic tests prove that the cannabidiol nasal preparation for treating the post-traumatic stress disorder has good anti-depressant andanti-anxiety effects, and can be used for treating the post-traumatic stress disorder.

The invention discloses a traditional Chinese medicine composition for treating mental anxiety. Generalized anxiety is a clinical common type, characterized by chronic anxiety and easy to recur and difficult to cure. Anxiety disorder has the main symptoms of fear and tension lacking definite objects and concrete contents, and is accompanied with vegetative nerve symptoms, muscular tension and motion disturbance of patients. On treatment, medicaments with anti-anxiety effects, such as benzodiazepines, tricyclic compounds, SSRIS (selective serotonin reuptake inhibitors) and the like are adopted generally, but the side reactions are relatively large. Anxiety disorder can be classified according to the aetiological agents into types of stagnation of the liver-qi, deficiency of both heart and spleen, deficiency of heart blood, moist heat in both liver and gall and deficiency of both qi and blood by differentiation of symptoms and signs in traditional Chinese medicine. The traditional Chinese medicine composition for treating mental anxiety is capable of soothing the liver and relieving depression, arresting convulsion and soothing nerves, and is used for treating mental depression, panic insomnia, chest distress and other symptoms. The traditional Chinese medicine composition is prepared from bupleurum, angelica, chuanxiong rhizome, tuckahoe, uncaria, multiflower knoweed stem, fried bighead atractylodes rhizome and licorice. In the prescription, the bupleurum is bitter in taste and cool in nature, has good efficacies on treating alternate attacks of chills and fever, fullness sensation in chest, hypochondriac pain, bitter taste, deafness, headache, dizziness and the like. The traditional Chinese medicine composition can alleviate patients from the suffering of mental anxiety and reduce the economic burden on patients. The traditional Chinese medicine composition is a pure traditional Chinese medicine oral preparation, and can be safely taken for a long term.

The invention discloses a traditional Chinese medicine composition with an anti-anxiety effect. The traditional Chinese medicine composition is prepared from the following crude medicaments in parts by weight: 10-18 parts of moutan bark, 10-18 parts of radix paeoniae alba, 6-12 parts of frankincense, 7-10 parts of fructus alpiniae oxyphyllae and 7-10 parts of inula flowers. The traditional Chinese medicine composition is mainly used for treating gas and phlegm obstruction and illness at ease of a sufferer with an anxiety disorder, can be used as an anti-anxiety medicament combination, also can be applied to a maintenance period or prevention of recurrence, and is applied to anxious emotion of a secondary body disease. The traditional Chinese medicine composition is applicable to medicament combination for the sufferer with various anxiety disorders of changeful symptoms and illness procrastination, or a medicament for the maintenance period, or a medicament for prevention of recurrence, is especially applicable to emotion regulation of body disease comorbidities such as anxiety, tumors, strokes, coronary heart diseases and the like. Therefore, the traditional Chinese medicine composition is broad in clinical medication prospect.

The present invention is a device for delivering a low frequency magnetic field pulse (Cnp) to affect the physiological and / or neurological conditions of an animal or human. In particular, distinct Cnps are designed to have anti-depression, analgesic, or anti-anxiety effects. These Cnps may be applied in combination in a sequence.

A Chinese herbal aqueous extract having anti-anxiety activities and a method of in vitro evaluating the same are disclosed. Neural cells and / or glial cells are cultured in a medium containing the Chinese herbal aqueous extract, and then subjected to an electric pulse treatment to form epileptic cells. The epileptic cells are applied on evaluation of at least one criterion of anti-anxiety activities of the Chinese herbal aqueous extract.

The invention discloses a series of lignan compounds. The series of lignan compounds are compounds as shown in a formula I, a formula II, a formula III, a formula IV, a formula V, a formula VI, a formula VII and a formula VIII. The invention also discloses a pharmaceutical composition which comprises the compounds; and a pharmaceutically acceptable carrier or diluent. The invention also discloses a preparation method of the compounds. The invention also discloses application of the series of lignan compounds in preparation of drugs with sedative, hypnotic, anti-depression and / or anti-anxiety effects or preparation of kits with sedative, hypnotic, anti-depression and / or anti-anxiety effects or in scientific research. The series of lignan compounds found by the invention are clear in function, good in effect and free of toxic and side effects, and can be used as potential sedative-hypnotic, anti-depression and anti-anxiety drugs.

The invention provides a cannabidiol liquid preparation with the anti-anxiety effect and a preparation method of the cannabidiol liquid preparation. The cannabidiol liquid preparation is prepared from the following raw materials in parts by weight: 5-10 parts of cannabidiol, 3-5 parts of rhizoma ligustici wallichii, 3-5 parts of semen ziziphi spinosae, 3-5 parts of cortedx moutan, 1-2 parts of corydalis tuber, 1-2 parts of radix rumicis nepalensis, 1-2 parts of herba hyperici perforati cum radice, 1-2 parts of rhizoma gastrodiae, 1-2 parts of stigma croci sativi, 1-2 parts of herba schizonepetae, 1-2 parts of herba dianthi, 1-2 parts of herba thlaspis arvensis, 1-2 parts of ramulus euonymi alati, 1-2 parts of flos jasmini grandiflori immaturus, 1-2 parts of os sepiae, 1-3 parts of essence, 25-30 parts of methyl salicylate, 600-650 parts of alcohol, and 282-355 parts of purified water. For the cannabidiol liquid preparation with the anti-anxiety effect and the preparation method of the cannabidiol liquid preparation, the anti-anxiety pharmacological action of cannabidiol is fully utilized, meanwhile, the plurality of traditional Chinese medicinal materials are mixed, so that the mind can be effectively soothed, and the anxiety can be alleviated.

The invention relates to a composition having efficacy of improving sleep and a preparation method of composition, as well as tablets and a preparation method thereof. The composition having efficacyof improving sleep comprises the following raw materials in parts by weight: 0.01-1 part of a jatamans valeriana rhizome extract, 0.1-1 part of a hop extract, 0.1-1 part of casein hydrolysate and 2-5parts of whey protein powder. According to the composition having efficacy of improving sleep, the jatamans valeriana rhizome extract having the effects of calming central nervous and resisting anxiety is used as a main drug, and the hop extract having the efficacy of calming and improving sleep disturbance is used as a minister drug, and the casein hydrolysate and the whey protein powder are added for assistance, so that the action regulation and immunomodulation capacity is improved, the development of the nervous system is promoted, and the sleep and the appetite are regulated; and the components are in mutual coordination in efficacy, and joint regulation is performed in the respects of nervous systems, immune systems and the like, so that the composition has good efficacy of improvingsleep, and effectively improves the insomnia of people.

The invention discloses a detection method of an anti-anxiety pharmaceutical composition and a detection method of capsules of the anti-anxiety pharmaceutical composition. The method is characterized by using high performance liquid chromatography (HPLC) to detect and carrying out linear relation test, precision test, repeatability test, stability test and recovery test and a series of tests. The detection method of the invention is accurate and effective, and can well control the product quality.

The invention relates to application of coptis and alkaloid thereof in preparation of an anti-anxiety medicament. The problem that the coptis or the alkaloid is applied in preparation of the anti-anxiety medicament can be effectively solved. The invention adopts the technical scheme that: the coptis is decocted into coptis decoction by adding water, or the coptis is extracted by using ethanol, then coptis alkaloid is prepared by using water bath, and the coptis water bath fluid or the coptis alkaloid is subjected to mouse cross maze or light and dark box passing experiments; and the experiment results show that the coptis and the alkaloid thereof have anti-anxiety effect. The application can expand the medicinal value of the coptis, and is an innovation on the anti-anxiety medicament.

The invention provides a use of ferulic acid in preparation of a drug for resisting mammal anxiety and provides a novel antianxiety drug having good effects and small side effects. Ferulic acid is an effective component of the antianxiety drug. Results of mouse elevated plus-maze test, hole-board test and spontaneous activity test on ferulic acid shows that ferulic acid has substantial antianxiety effects and no calmness effect and thus adverse reactions such as fatigue and somnolence caused by calmness effects of the existing antianxiety drug are avoided.

The invention discloses a preparation method of a pharmaceutical composition with anti-anxiety effect, active pharmaceutical ingredients of the pharmaceutical composition comprise jatamans valeriana rhizome, silktree albizzia bark, spine date seed and rush, and the preparation method comprises the following steps: step 1) selecting the active pharmaceutical ingredients according to the proportion; step 2) crushing the jatamans valeriana rhizome into coarse powder, and extracting with ethanol; step 3) crushing the spine date seed and the silktree albizzia bark into the coarse powder, and extracting with water; step 4) extracting the rush with the ethanol. Simultaneously, the invention further discloses the preparation method of pharmaceutical composition capsules. A rat elevated plus-maze test, a rat vogel drinking conflict test, a spontaneous drinking test and a pain threshold test are performed on the pharmaceutical composition, and the test results show that the pharmaceutical composition has the obvious anti-anxiety effect and has no sedation or side effects.

The invention discloses an agilawood essence cataplasm having an anxiolytic effect. The cataplasm consists of the following ingredients: 2.52g of Viscomate NP-700, 58.8mg of aluminium glycinate, 84mg of tartaric acid, 21mg of ethylene diamine tetraacetic acid (EDTA), 0.84g of carbomer 940, 1.68g of polyvinyl pyrrolidone (PVP), 15.12g of glycerol, 29.4g of distilled water and 0.5mL of agilawood essence. The invention also discloses a preparation method of the cataplasm, wherein the preparation method comprises steps of preparing a drug-containing cataplasm and coating and forming. The agilawood essence cataplasm disclosed by the invention, which is in the form of an ointment, is delicate in appearance, relatively comfortable in smell of agilawood, good in comfort and good in skin tracing property, and the agilawood essence cataplasm, after being formed and kept for a certain duration, is basically free from phenomenon of residue and adhesion; and the agilawood essence cataplasm has the relatively good anxiolytic effect.

The invention discloses a use of a Qing'e prescription extract in preparation of an antidepressant and anxiolytic composition. With oral administration of the Qing'e prescription extract, the experimental animal mine field movement total distance can be increased, the tail suspension immobility time is reduced, the elevated plus maze open-arm time is increased, the forced swimming immobility time is reduced, and relatively good antidepressant and anxiolytic effects are shown. The Qing'e prescription extract can increase the contents of hippocampal area 5-hydroxytryptamine (5-HT), norepinephrine (NE) and gamma-aminobutyric acid (gamma-GABA), and reduces the content of glutamate (Glu). On one hand, the gamma-GABA increasing role and the Glu reduction role of the Qing'e prescription extract indicate that the Qing'e prescription extract has a role in adjusting metabolism of central nervous system neurotransmitters Glu and gamma-GABA, reduces the Glu / gamma-GABA ratio, reduces transmission of GABAergic neurotransmitters, regulates the reactivity of a catecholamine acceptor, thereby playing antidepressant and anxiolytic roles. On the other hand, the Qing'e prescription extract increases the central nervous system 5-HT level and plays the antidepressant and anxiolytic roles by inhibiting the activity of monoamine oxidase.

The invention relates to an antianxiety traditional Chinese medicine composition and an application thereof. The antianxiety traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of daylily, 6-12 parts of processed rhizoma cyperi and 1-4 parts of fructus amomi, wherein the fructus amomi is added in a last step. The antianxiety traditional Chinese medicine composition provided by the invention has the advantages of being proper in matching, small in medicine amount and specific in effect, being capable of effectively relieving anxiety of anxious rat models, remarkably reducing content levels of 5-HT and NE of serum, increasing the content level of BDNF in the serum and reducing positive expression of NMDAR1 in rat hippocampus, being remarkable in antianxiety effect, being a pure traditional Chinese medicine preparation, and being free of toxic or side effect, good in security, easily acceptable by patients, small in medicine type, low in cost and convenient to prepare.

The present invention provides peptides for use in a medicament which is administered nasally, wherein the peptide is an agonist of neuropeptide S receptor (NPSR), of the receptor TGR23 and / or of vasopressin receptor-related receptor 1 (VRR1) or for use in the treatment of a patient by causing, promoting or increasing relieve or healing of phobic anxiety, avoidance anxiety, dissociative anxiety such as flashbacks, depersonalization, derealization, intrusions, vegetative symptoms related to anxiety symptoms, especially in panic attacks, in posttraumatic stress disorder, in generalised anxiety disorder and in anxiety accompanying depressive, or psychotic episodes, arousal, awakening, alertness, activity, spontaneous movement, an anxiolytic effect or a combination thereof in the patient, wherein the peptide is administered nasally or for use in the prophylaxis and / or treatment of an anxiety or sleep disorder, especially in any type of hypersomnia like idiopathic hypersomnia, wherein the peptide is administered nasally. Further provided are pharmaceutical compositions for nasal administration comprising at least one of said peptides, uses of said peptide or said pharmaceutical composition. The invention also provides a method for identifying target neurons of a peptide in an animal, wherein the peptide is administered nasally.

The invention discloses a preparation method of a pharmaceutical composition with anti-anxiety effect, active pharmaceutical ingredients of the pharmaceutical composition comprise jatamans valeriana rhizome, silktree albizzia bark, spine date seed and rush, and the preparation method comprises the following steps: step 1) selecting the active pharmaceutical ingredients according to the proportion; step 2) crushing the jatamans valeriana rhizome into coarse powder, and extracting with ethanol; step 3) crushing the spine date seed and the silktree albizzia bark into the coarse powder, and extracting with water; step 4) extracting the rush with the ethanol. Simultaneously, the invention further discloses the preparation method of pharmaceutical composition capsules. A rat elevated plus-maze test, a rat vogel drinking conflict test, a spontaneous drinking test and a pain threshold test are performed on the pharmaceutical composition, and the test results show that the pharmaceutical composition has the obvious anti-anxiety effect and has no sedation or side effects.

The invention belongs to the field of drugs or health products and particularly relates to an application of NADPH in preparation of anti-anxiety drugs. The research finds that the NADPH is capable of significantly improving the exploration interest, significantly reducing the anxiety level of a rat and reversing anxiety behaviors caused by chronic stress. The results show that the NADPH has an anti-anxiety effect, and can be used as a potential drug for preventing or treating generalized anxiety disorder.