2 results about "Benserazide" patented technology

This invention provides a pharmaceutical composition for improving memory function, relating to the field of pharmaceutical technology. The composition comprises vitamin B6, vitamin B12, lutein, anthocyanins, phosphatidylserine, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), levodopa, benserazide, and selegiline. Vitamin B6, vitamin B12, lutein, anthocyanins, phosphatidylserine, DHA, and EPA nourish the brain; levodopa, benserazide, and selegiline are used for neuropharmacological treatment; anthocyanins, lutein, and EPA synergistically improve cerebral microcirculation, enhance blood oxygen supply, scavenge free radicals, reduce inflammation, and decrease brain cell aging and necrosis, thereby delaying the process of memory decline; levodopa, benserazide, and selegiline synergistically supplement and protect dopamine, with benserazide enhancing the bioavailability of levodopa and selegiline inhibiting dopamine degradation.

The application belongs to the technical field of biological medicine, and specifically discloses application of benserazide hydrochloride in preparation of anxiolytic drugs. The application first finds that benserazide hydrochloride plays an anxiolytic role by regulating the kynurenine metabolic pathway. Animal experiments prove that benserazide hydrochloride can promote the generation of kynurenine and its downstream metabolite 3-hydroxyanthranilic acid, and maintain the stable level of 3-hydroxykynurenine, thereby improving the function of the metabolic pathway and restoring the nervous system homeostasis. Behavioral experiments show that benserazide hydrochloride can increase the exploration behavior of zebrafish and reduce the avoidance behavior, and meanwhile, does not cause inhibition of motor function or sedative effect, and shows good safety and selectivity. The application provides a theoretical basis and a new drug source for the prevention and / or treatment of anxiety.