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Application of benserazide as antibacterial agent

An antibacterial agent and bacterial technology, applied in the field of antibacterial preparation research and development, can solve the problems of limited treatment methods for CRKP and achieve the effect of solving bacterial infection

Active Publication Date: 2020-12-15
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing studies have shown that CRKP drug resistance is mainly due to the production of carbapenemase by the strain, which can efficiently hydrolyze penicillin, cephalosporin, aztreonam and carbapenem antibiotics. limited

Method used

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  • Application of benserazide as antibacterial agent
  • Application of benserazide as antibacterial agent
  • Application of benserazide as antibacterial agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1BZ

[0060] The in vitro action determination of embodiment 1BZE anti-drug-resistant bacteria

[0061] 1. Materials

[0062] 1.1 Experimental strains

[0063] Two MRSA strains, two MDRAB strains, and two CRKP strains were isolated and identified by the Microbiology Laboratory of Qilu Children's Hospital of Shandong University.

[0064] 1.2 Drugs and main reagents

[0065] Benserazide (BZE), Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai);

[0066] Calcium-adjusted MH Broth Medium (CAMHB), Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0067] MHA agar medium, Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0068] Normal saline, Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai).

[0069] 1.3 Instruments

[0070] Electronic balance (AUY120), SHIMADZU CORPORATION (Japan);

[0071] Bacteria collection ring, Huanyao Pharmaceutical Equipment Sales Co., Ltd. (Beijing, China);

[0...

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PUM

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Abstract

The invention particularly relates to application of BZE as an antibacterial agent. Aiming at the current situations that drug-resistant bacteria are increased year by year, the research and development period of antibacterial drugs is long, and the marketing speed is low at present, non-antibiotic drugs with an antibacterial effect are developed in the field and used for coping with the troublesome current situation that the drug-resistant bacteria are difficult to treat. Based on the technical thought, BZE is screened and verified to have a good antibacterial effect, and has a good in-vitrocomplete inhibition effect on MRSA, MDRAB and CRKP with high drug resistance. Based on the research result, the BZE is expected to be developed as an effective component of a broad-spectrum antibacterial drug, and has good clinical treatment and economic significance.

Description

technical field [0001] The invention belongs to the technical field of research and development of antibacterial preparations, and in particular relates to the application of benserazide as an antibacterial active ingredient in the preparation of antibacterial preparations. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Benserazide (benserazide, BZE) is a peripheral dopa decarboxylase inhibitor. Generally, benserazide and levodopa are used in combination for Parkinson's disease and Parkinson's syndrome. The pharmacological effect of benserazide is similar to that of carbidopa, and it is difficult to penetrate the blood-cerebrospinal fluid barrier. It is absorbed quickly...

Claims

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Application Information

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IPC IPC(8): A61K31/165A61P31/04A01N37/36A01P1/00
CPCA01N37/36A61K31/165A61P31/04A61K2300/00
Inventor 李秀云张运奎郝丽娜
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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