Microsphere combination medicament containing antiparkinsonism drug and application thereof
A Parkinson's disease and composition technology, which is applied in the field of microsphere compositions, can solve the problems of unstable levodopa nano preparations, easy aggregation of nanoparticles, toxic and side effects, etc., to achieve good medicinal prospects, improve curative effect, reduce The effect of AIM scoring
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Embodiment 1
[0041] ①Preparation of mixed drug solution of levodopa methyl ester and benserazide
[0042] a) Mix 100 mg of levodopa methyl ester and benserazide (according to the weight ratio of 1:1) purchased in the market, and prepare the concentration of 2.5% by weight;
[0043] ②Preparation of sustained-release microsphere composition of levodopa methyl ester and benserazide mixed drug
[0044] a) Measure 0.2mL, 0.5mL or 1mL of the mixed drug solution of levodopa methyl ester and benserazide obtained in ①, and weigh 595mg of polyglycolic acid-polylactic acid (PLGA molecular weight is 6000), 37.5mg of Polyglycolic acid-polylactic acid (PLGA molecular weight is 250,000) or 25 mg of polyglycolic acid-polylactic acid (PLGA molecular weight is 500,000) and is prepared into an organic solution of 30%, 15% or 5% by weight concentration of dichloromethane respectively 30% concentration and 0.2mL, 15% and 0.5mL or 5% and 1mL of the above solutions are mixed one by one correspondingly and stirr...
Embodiment 2
[0052] ①Preparation of mixed drug solution of levodopa methyl ester and benserazide
[0053] a) Mixing 100 mg of levodopa methyl ester and benserazide (according to the weight ratio of 2: 1) purchased on the market to prepare a concentration of 2.5% by weight;
[0054] ②Preparation of sustained-release microsphere composition of levodopa methyl ester and benserazide mixed drug
[0055] a) Measure 0.2mL, 0.5mL or 1mL of the mixed drug solution of levodopa methyl ester and benserazide obtained in ① respectively and weigh 595mg of polylactic acid (PLA molecular weight is 6000), 37.5mg of polylactic acid (PLA Molecular weight is 250,000) or polylactic acid (PLA molecular weight is 500,000) of 25mg and is prepared into the organic solution of the methylene chloride of 30%, 15% or 5% by weight percentage concentration respectively; Will use 30% concentration and 0.2mL, 15 % and 0.5mL or 5% and 1mL of the above solutions are mixed one by one and stirred, vortexed or ultrasonically for...
Embodiment 3
[0063] ①Preparation of mixed drug solution of levodopa methyl ester and benserazide
[0064] a) Mix 100 mg of levodopa methyl ester and benserazide (according to the weight ratio of 3:1) purchased in the market, and prepare the concentration of 2.5% by weight;
[0065] ②Preparation of sustained-release microsphere composition of levodopa methyl ester and benserazide mixed drug
[0066] a) Measure 0.2mL, 0.5mL or 1mL of the mixed drug solution of levodopa methyl ester and benserazide obtained in ①, and weigh 595mg of polycaprolactone (PCL molecular weight is 10,000), 37.5mg of polycaprolactone Lactone (PCL molecular weight is 2,500,000) or 25mg of polycaprolactone (PCL molecular weight is 5,000,000) and is prepared into an organic solution of dichloromethane with a concentration of 30%, 15% or 5% by weight; 30% concentration will be used and 0.2mL, 15% and 0.5mL or 5% and 1mL of the above solutions in the order of one-to-one mixing and stirring, vortex or ultrasonic 1-5 minute...
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