34 results about "Stilbene derivative" patented technology

The invention belongs to the technical field of medicines, and particularly relates to quinazoline stilbene derivatives as well as a preparation method, a composition and application thereof. The quinazoline stilbene derivative is synthesized by combining quinazoline with pharmacophores such as a styrene skeleton, and the quinazoline stilbene derivative structurally contains functional units such as a quinazoline functional unit and the pharmacophores such as the styrene skeleton, so that the compound is endowed with good anti-tumor activity. Researches show that the quinazoline stilbene derivative has a good anti-tumor effect including KRASG12C mutation non-small cell lung cancer, has the advantage of multi-target action, has an adjusting effect on Src kinase and related downstream signal channels of Statat, mTOR, Akt and PI3k, and is beneficial to reduction of tumor drug resistance. Compared with a complex structure modified compound, the quinazoline stilbene derivative disclosed by the invention is simple in structure and easy to prepare, and has a good application prospect.

The present invention relates to a method for imitating or enhancing the perception or taste of alcohol in an edible preparation, in which an edible preparation is brought into contact with at least one component, wherein the component is selected from the group comprising stilbene, stilbene derivatives, plant extract containing stilbene and / or at least one stilbene derivative, or a mixture thereof.

Provided herein are novel antibacterial compounds of Formula I. The compounds can be made through enzymatic oxidative dimerization in the presence of a suitable organism and one or more metal salts. Pathogenic bacteria exposed to the compound of Formula I do not develop resistance to these compounds even after prolonged exposure. Also provided herein are methods of treating bacterial infections, and method of killing or disinfecting bacteria.

The present invention relates to a method for mimicking or enhancing the alcohol perception or flavour of a consumable preparation by using at least one component (S) which is selected from the group comprising stilbene, stilbene derivatives, plant extract containing stilbene and / or at least one stilbene derivative, or a mixture thereof, and in particular bringing a consumable preparation into contact with such at least one component (S).

The invention belongs to the technical field of fine chemicals and related chemistry, and discloses a heterogeneous preparation method of a stilbene derivative, the method uses a high-entropy alloy as a catalyst, the reaction selectivity is high, the reaction system is simple, the substrate compatibility is good, the highest yield can reach more than 95%, and the catalyst has good stability and can be recycled. Iodo derivatives and olefin derivatives are used as raw materials to react for 6-10 hours in an organic solvent at 120-140 DEG C under the air condition and under the action of a high-entropy alloy catalyst and alkali to obtain the corresponding stilbene hydrocarbon compound, and the stilbene hydrocarbon compound has wide application and has an important position in drug design and drug synthesis.

The present invention relates to stilbene derivatives as AhR activators and their use. The compounds of the present invention, their pharmaceutically acceptable salts, tautomers or stereoisomers have excellent AhR activating effects and can be safely used for the treatment of diseases or related conditions mediated by abnormal activation of AhR and related pathway targets. [Chemical 1] JPEG2025516369000086.jpg32169

The present invention provides a stilbene derivative of guaiazulene, which belongs to the technical field of medicinal chemistry. The present invention combines guaiazulene with a stilbene skeleton for pharmacophore combination to synthesize stilbene derivatives of guaiazulene. This structure contains guaiazulene functional units and stilbene skeleton functional units, which can give such compounds a wide range of anti-tumor and anti-influenza virus activities, laying the foundation for the development of stilbene derivatives of guaiazulene as anti-tumor and anti-influenza virus candidate drugs. The results of the examples show that the stilbene derivatives of guaiazulene provided by the present invention have certain inhibitory activity on human chronic myeloid leukemia cells K562, human breast cancer cells MDA-MB-231, and human pancreatic cancer cells ASPC-1; the stilbene derivatives of guaiazulene provided by the present invention have certain inhibitory activity on H1N1 virus, which is the first time that a compound with antiviral activity has been found from guaiazulene derivatives, broadening the direction of antiviral drug development.

Provided in the present disclosure are stilbene derivatives, a preparation method therefor and the use thereof. Specifically, provided in the present disclosure is the use of compounds represented by formula (I-1), and stereoisomers, pharmaceutically acceptable salts or prodrugs thereof as an aryl hydrocarbon receptor (AHR) regulator. Compared with marketed drug Benvitimod, the compounds represented by formula I-1 have greatly improved molecular structure stability under illumination, thus overcoming photoinstability of Benvitimod, and solving the problem of Benvitimod being liable to degrade under illumination. In addition, the compounds represented by formula I-1 have remarkably improved activity on AHR protein. And finally, the preparation method for the compounds represented by formula I-1 is simple, and can achieve gram-level or kilogram-level preparation. Therefore, the compounds have better prospects in subsequent preparation development, safety and clinical use.

The invention discloses synthesis and application research of a cyanostilbene derivative, and relates to the technical field of organic fluorescent dyes. The invention relates to synthesis and application research of a cyanostilbene derivative. The synthesis and application research comprises the following steps: a synthesis route of a target product 2e, a focusing induction effect, an organic light-emitting diode, a solvent effect and an acid / alkali stimulated fluorescence response. According to the invention, 2e has a two-state luminescence property, and an AN solution of 2e has sensitive and reversible fluorescence response to acid / alkali stimulation, so that 2e is suitable for an acid / alkali fluorescence sensor. In solvents with different polarities, 2e emits fluorescence with different colors, the relative polarity of the solvents can be judged through naked eyes, the 2e is made into small LED lamp beads emitting green light, the 2e can be widely applied to toys, building decoration and warning signs of'safety channels' and'emergency exits', in addition, the 2e has the AIEE effect, the fluorescence intensity is the strongest when the water content is 85%, and the 2e can be used as a warning sign of the safety channels and the emergency exits. And the fluorescence performance of the material under specific conditions is improved.

The invention discloses a stilbene derivative, a preparation method thereof and application of the stilbene derivative in preparation of drugs for treating psoriasis or ulcerative colitis, and belongs to the technical field of biological medicines. The compounds II-2 and II-23 provided by the invention are used for targeted excitation of AHR related pathways, promotion of AHR nucleation, reduction of secretion of related cytokines at a cellular level, and substantial improvement of mouse skin symptoms and PASI scores of an imiquimod-induced mouse psoriasis model, compared with a lead compound benvimod, the compounds II-2 and II-23 have better psoriasis resistance activity and lower toxicity, and can be used for preparation of drugs for treating psoriasis. Meanwhile, the compound II-23 is found to be capable of effectively treating mouse ulcerative colitis, reducing inflammatory response and improving colitis symptoms. The compound can be used for preparing medicines for treating psoriasis and ulcerative colitis.

The application discloses a biphenyl derivative photoinitiator, a preparation method thereof, a photocuring film material and a preparation method and application thereof. The biphenyl derivative photoinitiator has a structural formula as shown in formula (I), R1 is an electron donor group, and R2 is an electron acceptor group. In the application, the biphenyl is used as a main body structure, different donor groups R1 and acceptor groups R2 are connected, a photoinitiator is synthesized through a Suzuki reaction, and a polymer monomer material is N,N-dimethyl acrylamide (DMA). The photocuring material with long afterglow luminescence can be obtained through a method of ultraviolet light irradiation, under the irradiation of a 365 nm ultraviolet lamp, the initiator absorbs photons to generate active species to attack double bonds in monomers to initiate a polymerization reaction. The photocuring film can produce long afterglow luminescence for several seconds after light irradiation, and can be applied to aspects of anti-counterfeiting, 3D printing and photolithography.

The present disclosure relates to use of a stilbene derivative in the prevention and / or treatment of ulcers. A compound of formula (I) or a pharmaceutically acceptable salt thereof can effectively prevent or treat ulcers, and in particular, has a curative effect on oral ulcers.

The present disclosure provides for a rhodium-catalyzed oxidative arene alkenylation from arenes and styrenes to prepare stilbene and stilbene derivatives. For example, the present disclosure provides for method of making arenes or substituted arenes, in particular stilbene and stilbene derivatives, from a reaction of an optionally substituted arene and / or optionally substituted styrene. The reaction includes a Rh catalyst or Rh pre-catalyst material and an oxidant, where the Rh catalyst or Rh catalyst formed Rh pre-catalyst material selectively functionalizes CH bond on the arene compound (e.g., benzene or substituted benzene).

The present application provides the use of a compound represented by Formula I, a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof as an aryl hydrocarbon receptor (AHR) modulator. The compound represented by Formula I greatly improves the light stability of the molecular structure compared to the marketed drug benvepidimod, improves the light instability of benvepidimod, and is easily degraded under light. In addition, the activity on the AHR protein is also significantly improved. Finally, the preparation method of the compound represented by Formula I is simple, and can be prepared in kilograms or kilograms, which has a better prospect in subsequent formulation development, safety and clinical application.

The invention relates to the field of organic light-emitting materials and ion recognition, and particularly provides a cyano stilbene derivative, a preparation method thereof and application of the cyano stilbene derivative in zinc ion recognition and recovery rate detection. Firstly, a tris (2-aminoethyl) amine tripod bridged cyano-stilbene derivative TCS is designed and synthesized, cyano-stilbene groups on three sides of the tris (2-aminoethyl) amine tripod bridged cyano-stilbene derivative TCS provide fluorophores for the molecule, and the tris (2-aminoethyl) amine tripod provides a flexible framework bridged with the cyano-stilbene groups. Under the driving of supramolecular self-assembly, the single-component TCS can perform fluorescence colorimetric detection on zinc ions in a THF / H2O system under the condition that the detection limit is as low as 41nM, the fluorescence color is changed from yellow green to cyan, and the single-component TCS has an efficient single recognition characteristic; by means of the characteristic, the TCS can be widely applied to drinking water quality monitoring and industrial wastewater discharge detection, and the water quality safety guarantee level is remarkably improved.

The present application provides a polygonum multiflorum starch-stilbene derivative complex, a preparation method and application thereof, and belongs to the technical field of starch complexes. The polygonum multiflorum starch is compounded with the stilbene derivative (or the polygonum multiflorum starch, polysaccharide and stilbene derivative are compounded), which is beneficial to improve the stability of the stilbene derivative. Specifically, after the polygonum multiflorum starch and the stilbene derivative form the complex, the amylose in the starch and the stilbene derivative are tightly wrapped, so that the hydrolysis of the digestive enzyme is slowed down, and the digestibility of the polygonum multiflorum starch is affected. The starch or starch + polysaccharide wrapped stilbene derivative can enhance the bioavailability of the stilbene derivative in the body. The polygonum multiflorum starch-stilbene derivative complex has a stable structure, the compounding degree is more than 80%, the release rate of the stilbene derivative in the simulated gastrointestinal fluid is effectively slowed down, and the biological activity of the stilbene derivative is better maintained.

The present disclosure provides a stilbene derivative, a preparation method and use thereof, in particular, the present disclosure provides a compound represented by formula (I-1), a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof as an aromatic hydrocarbon receptor (AHR) modulator. The compound represented by formula I-1 greatly improves the light stability of the molecular structure compared with the marketed drug benvepick, improves the light instability of benvepick, and is easily degraded under light. In addition, the activity on AHR protein is also significantly improved. Finally, the preparation method of the compound represented by formula I-1 is simple, and can be prepared in kilograms or kilograms, which has a better prospect in subsequent preparation development, safety and clinical application.

Stilbene derivatives, a preparation method therefor and the use thereof are provided. Compounds of formula (I-1), and stereoisomers, pharmaceutically acceptable salts or prodrugs thereof can serve as an aryl hydrocarbon receptor (AHR) regulator. Compared with marketed drug Benvitimod, the compounds of formula I-1 have greatly improved molecular structure stability under illumination, thus overcoming photoinstability of Benvitimod, and solving the problem of Benvitimod being liable to degrade under illumination. In addition, the compounds of formula I-1 have remarkably improved activity on AHR protein. And finally, the preparation method for the compounds of formula I-1 is simple, and can achieve gram-level or kilogram-level preparation.

This invention relates to a stilbene derivative and a method of preparing the same, and more particularly to a novel stilbene derivative for inhibiting the function of cyclophilin, which is effective at the prevention of cyclophilin-related diseases or at the treatment of symptoms of such diseases, and to a method of preparing the same.

This application relates to the fields of organic light-emitting materials and ion recognition, and more specifically, it provides a cyanostilbene derivative, its preparation method, and its application in zinc ion recognition and recovery detection. Firstly, this application designs and synthesizes a tri(2-aminoethyl)amine triangular framework-bridged cyanostilbene derivative TCS. The cyanostilbene groups on its three sides provide the fluorophore, while the tri(2-aminoethyl)amine triangular framework provides the flexible framework bridging the cyanostilbene groups. Driven by supramolecular self-assembly, this single-component TCS can perform fluorescence colorimetric detection of zinc ions in a THF / H2O system with a detection limit as low as 41 nM. The fluorescence color changes from yellow-green to cyan, exhibiting highly efficient single-recognition characteristics. Utilizing this characteristic, TCS can be widely applied to drinking water quality monitoring and industrial wastewater discharge detection, significantly improving water quality safety assurance levels.

A stilbene derivative can be used in the prevention and / or treatment of ulcers. A compound of formula (I) or a pharmaceutically acceptable salt thereof can effectively prevent or treat ulcers, and in particular, has a curative effect on oral ulcers.

A super-bright fluorescent probe for cellular lipid droplets and its application in the preparation of bioimaging reagents, belonging to the field of bioimaging technology. Aiming at the deficiencies of the existing fluorescent imaging probes for cellular lipid droplets in terms of insufficient photostability and insufficient selectivity for lipid droplet staining, the present invention selects a fluorescent molecule based on stilbene derivatives in the development of a new type of fluorescent probe for lipid droplet imaging. While exhibiting high photostability, this fluorescent molecule has excellent selectivity for lipid droplet staining. This fluorescent probe can be used to prepare reagents for specifically labeling lipid droplets in cells, visually tracking the dynamic trajectories of cellular lipid droplets, and quantitatively measuring the movement speed of cellular lipid droplets. The fluorescent probe Lipi-Bright described in the present invention has excellent photostability and staining selectivity. Under the same staining and imaging conditions, Lipi-Bright exhibits more excellent photostability and staining selectivity than commercial fluorescent probes for lipid droplets, and has great application prospects.

The present invention relates to a stilbene derivative as an AhR activator and use thereof. The compound of formula (I), or a pharmaceutically acceptable salt, a tautomer or a stereoisomer thereof has an AhR activation effect, and can be safely used for treating a disease or a related symptom mediated by activity abnormality of AhR and related pathway targets.

The invention provides a polygonum multiflorum starch-stilbene derivative compound as well as a preparation method and application thereof, and belongs to the technical field of starch compounds. The fleece-flower root starch and the stilbene derivative are compounded (or fleece-flower root starch, polysaccharide and the stilbene derivative are compounded), the stability of the stilbene derivative is improved, specifically, after the fleece-flower root starch and the stilbene derivative form a compound, amylose in the starch and the stilbene derivative are tightly wrapped, and the stability of the stilbene derivative is improved. Therefore, the hydrolysis of digestive enzyme is retarded, and the digestion performance of the polygonum multiflorum starch is influenced; and the stilbene derivative is wrapped by the starch or the starch and the polysaccharide, so that the bioavailability of the stilbene derivative in vivo is enhanced. The polygonum multiflorum starch-stilbene derivative compound has a stable structure, the compounding degree reaches 80% or above, the release rate of the stilbene derivative in simulated gastrointestinal fluid is effectively slowed down, and the biological activity of the stilbene derivative is better maintained.

The invention discloses a light capture system based on a dicyanostilbene derivative and a preparation method and application thereof. According to the light capture system, a supermolecular nano aggregate formed by assembling a p-methylpyridinium modified dicyanostilbene derivative and polyacrylic acid through electrostatic interaction is used as a light capture antenna and an energy donor, and a fluorescent dye loaded on the supermolecular nano aggregate is used as an energy receptor. The light capture system provided by the invention has a wide color regulation and control range and remarkably enhanced active oxygen (including < 1 > O2 and O2) generation capability. Under the water phase condition, the light capture antenna of the system can enhance the generation of ROS, and after the fluorescent dye is loaded, the ROS is further enhanced.

The invention relates to a photoisomerization chiral hydrogel material as well as a preparation method and application thereof, and belongs to the field of supramolecular materials. The photoisomerization chiral hydrogel material is synthesized by adopting a stilbene derivative to modify a symmetric phenylalanine derivative through a three-step liquid phase reaction (amidation, trifluoroacetic acid deprotection and amidation), and the structural formula of the gel material is shown as a formula (I) or a formula (II), # imgabs0 #; the prepared nanogel material with uniform chirality successfully simulates a chiral helical structure of an extracellular microenvironment, the preparation method is simple and convenient, and the obtained hydrogel has good biocompatibility, can realize non-destructive three-dimensional packaging and light-operated release of cells, and has good application prospects. The material has a good application prospect in the fields of drug controlled release carriers, tissue engineering scaffold materials and the like.

The present invention relates to stilbene derivatives and a method for preparing the same. More particularly, the present invention relates to novel stilbene derivatives which inhibit the function of cyclophilins and are effective in preventing cyclophilin-related diseases or treating symptoms thereof, and a method for preparing the same.

The present disclosure provides stilbene derivatives and their preparation and use. Specifically, the present disclosure provides the use of a compound represented by Formula I-1, its stereoisomer, pharmaceutically acceptable salt, or prodrug as an aromatic hydrocarbon receptor (AHR) modulator. The compound represented by Formula I-1 has significantly improved photostability of its molecular structure compared to the commercially available drug benvitimod, thereby alleviating benvitimod's photoinstability and susceptibility to decomposition under light irradiation. Furthermore, it has significantly improved activity against the AHR protein. Finally, the compound represented by Formula I-1 can be produced by a simple method at gram or kilogram levels, and has better prospects for subsequent formulation development, safety, and clinical application. [Formula 1] JPEG2025533578000047.jpg26169

The present invention discloses a stilbene derivative and its preparation method and its application in the preparation of a medicine for treating psoriasis or ulcerative colitis, and belongs to the field of biomedicine technology. Its structural formula is as follows: Compound II 2 and II 23 provided by the present invention target and excite AHR related pathways, promote AHR to enter the nucleus, reduce the secretion of related cytokines at the cellular level, significantly improve imiquimod-induced mouse psoriasis model to obtain mouse skin symptoms and PASI scores, compared to the lead compound benvimod, its anti-psoriatic activity is better and less toxic, and it is found that compound II 23 can effectively treat mouse ulcerative colitis, reduce inflammatory response, and improve colitis symptoms. The compounds of the present invention can be used to prepare medicines for the treatment of psoriasis and ulcerative colitis.