21 results about "Stilbene derivative" patented technology

The present invention relates to a method for imitating or enhancing the perception or taste of alcohol in an edible preparation, in which an edible preparation is brought into contact with at least one component, wherein the component is selected from the group comprising stilbene, stilbene derivatives, plant extract containing stilbene and / or at least one stilbene derivative, or a mixture thereof.

The present invention relates to a method for mimicking or enhancing the alcohol perception or flavour of a consumable preparation by using at least one component (S) which is selected from the group comprising stilbene, stilbene derivatives, plant extract containing stilbene and / or at least one stilbene derivative, or a mixture thereof, and in particular bringing a consumable preparation into contact with such at least one component (S).

The present invention provides a stilbene derivative of guaiazulene, which belongs to the technical field of medicinal chemistry. The present invention combines guaiazulene with a stilbene skeleton for pharmacophore combination to synthesize stilbene derivatives of guaiazulene. This structure contains guaiazulene functional units and stilbene skeleton functional units, which can give such compounds a wide range of anti-tumor and anti-influenza virus activities, laying the foundation for the development of stilbene derivatives of guaiazulene as anti-tumor and anti-influenza virus candidate drugs. The results of the examples show that the stilbene derivatives of guaiazulene provided by the present invention have certain inhibitory activity on human chronic myeloid leukemia cells K562, human breast cancer cells MDA-MB-231, and human pancreatic cancer cells ASPC-1; the stilbene derivatives of guaiazulene provided by the present invention have certain inhibitory activity on H1N1 virus, which is the first time that a compound with antiviral activity has been found from guaiazulene derivatives, broadening the direction of antiviral drug development.

Provided in the present disclosure are stilbene derivatives, a preparation method therefor and the use thereof. Specifically, provided in the present disclosure is the use of compounds represented by formula (I-1), and stereoisomers, pharmaceutically acceptable salts or prodrugs thereof as an aryl hydrocarbon receptor (AHR) regulator. Compared with marketed drug Benvitimod, the compounds represented by formula I-1 have greatly improved molecular structure stability under illumination, thus overcoming photoinstability of Benvitimod, and solving the problem of Benvitimod being liable to degrade under illumination. In addition, the compounds represented by formula I-1 have remarkably improved activity on AHR protein. And finally, the preparation method for the compounds represented by formula I-1 is simple, and can achieve gram-level or kilogram-level preparation. Therefore, the compounds have better prospects in subsequent preparation development, safety and clinical use.

The application discloses a biphenyl derivative photoinitiator, a preparation method thereof, a photocuring film material and a preparation method and application thereof. The biphenyl derivative photoinitiator has a structural formula as shown in formula (I), R1 is an electron donor group, and R2 is an electron acceptor group. In the application, the biphenyl is used as a main body structure, different donor groups R1 and acceptor groups R2 are connected, a photoinitiator is synthesized through a Suzuki reaction, and a polymer monomer material is N,N-dimethyl acrylamide (DMA). The photocuring material with long afterglow luminescence can be obtained through a method of ultraviolet light irradiation, under the irradiation of a 365 nm ultraviolet lamp, the initiator absorbs photons to generate active species to attack double bonds in monomers to initiate a polymerization reaction. The photocuring film can produce long afterglow luminescence for several seconds after light irradiation, and can be applied to aspects of anti-counterfeiting, 3D printing and photolithography.

The present disclosure relates to use of a stilbene derivative in the prevention and / or treatment of ulcers. A compound of formula (I) or a pharmaceutically acceptable salt thereof can effectively prevent or treat ulcers, and in particular, has a curative effect on oral ulcers.

The present disclosure provides for a rhodium-catalyzed oxidative arene alkenylation from arenes and styrenes to prepare stilbene and stilbene derivatives. For example, the present disclosure provides for method of making arenes or substituted arenes, in particular stilbene and stilbene derivatives, from a reaction of an optionally substituted arene and / or optionally substituted styrene. The reaction includes a Rh catalyst or Rh pre-catalyst material and an oxidant, where the Rh catalyst or Rh catalyst formed Rh pre-catalyst material selectively functionalizes CH bond on the arene compound (e.g., benzene or substituted benzene).

The present application provides the use of a compound represented by Formula I, a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof as an aryl hydrocarbon receptor (AHR) modulator. The compound represented by Formula I greatly improves the light stability of the molecular structure compared to the marketed drug benvepidimod, improves the light instability of benvepidimod, and is easily degraded under light. In addition, the activity on the AHR protein is also significantly improved. Finally, the preparation method of the compound represented by Formula I is simple, and can be prepared in kilograms or kilograms, which has a better prospect in subsequent formulation development, safety and clinical application.

The present application provides a polygonum multiflorum starch-stilbene derivative complex, a preparation method and application thereof, and belongs to the technical field of starch complexes. The polygonum multiflorum starch is compounded with the stilbene derivative (or the polygonum multiflorum starch, polysaccharide and stilbene derivative are compounded), which is beneficial to improve the stability of the stilbene derivative. Specifically, after the polygonum multiflorum starch and the stilbene derivative form the complex, the amylose in the starch and the stilbene derivative are tightly wrapped, so that the hydrolysis of the digestive enzyme is slowed down, and the digestibility of the polygonum multiflorum starch is affected. The starch or starch + polysaccharide wrapped stilbene derivative can enhance the bioavailability of the stilbene derivative in the body. The polygonum multiflorum starch-stilbene derivative complex has a stable structure, the compounding degree is more than 80%, the release rate of the stilbene derivative in the simulated gastrointestinal fluid is effectively slowed down, and the biological activity of the stilbene derivative is better maintained.

The present disclosure provides a stilbene derivative, a preparation method and use thereof, in particular, the present disclosure provides a compound represented by formula (I-1), a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof as an aromatic hydrocarbon receptor (AHR) modulator. The compound represented by formula I-1 greatly improves the light stability of the molecular structure compared with the marketed drug benvepick, improves the light instability of benvepick, and is easily degraded under light. In addition, the activity on AHR protein is also significantly improved. Finally, the preparation method of the compound represented by formula I-1 is simple, and can be prepared in kilograms or kilograms, which has a better prospect in subsequent preparation development, safety and clinical application.

Stilbene derivatives, a preparation method therefor and the use thereof are provided. Compounds of formula (I-1), and stereoisomers, pharmaceutically acceptable salts or prodrugs thereof can serve as an aryl hydrocarbon receptor (AHR) regulator. Compared with marketed drug Benvitimod, the compounds of formula I-1 have greatly improved molecular structure stability under illumination, thus overcoming photoinstability of Benvitimod, and solving the problem of Benvitimod being liable to degrade under illumination. In addition, the compounds of formula I-1 have remarkably improved activity on AHR protein. And finally, the preparation method for the compounds of formula I-1 is simple, and can achieve gram-level or kilogram-level preparation.

This application relates to the fields of organic light-emitting materials and ion recognition, and more specifically, it provides a cyanostilbene derivative, its preparation method, and its application in zinc ion recognition and recovery detection. Firstly, this application designs and synthesizes a tri(2-aminoethyl)amine triangular framework-bridged cyanostilbene derivative TCS. The cyanostilbene groups on its three sides provide the fluorophore, while the tri(2-aminoethyl)amine triangular framework provides the flexible framework bridging the cyanostilbene groups. Driven by supramolecular self-assembly, this single-component TCS can perform fluorescence colorimetric detection of zinc ions in a THF / H2O system with a detection limit as low as 41 nM. The fluorescence color changes from yellow-green to cyan, exhibiting highly efficient single-recognition characteristics. Utilizing this characteristic, TCS can be widely applied to drinking water quality monitoring and industrial wastewater discharge detection, significantly improving water quality safety assurance levels.

A stilbene derivative can be used in the prevention and / or treatment of ulcers. A compound of formula (I) or a pharmaceutically acceptable salt thereof can effectively prevent or treat ulcers, and in particular, has a curative effect on oral ulcers.

The present invention relates to a stilbene derivative as an AhR activator and use thereof. The compound of formula (I), or a pharmaceutically acceptable salt, a tautomer or a stereoisomer thereof has an AhR activation effect, and can be safely used for treating a disease or a related symptom mediated by activity abnormality of AhR and related pathway targets.

The invention discloses a light capture system based on a dicyanostilbene derivative and a preparation method and application thereof. According to the light capture system, a supermolecular nano aggregate formed by assembling a p-methylpyridinium modified dicyanostilbene derivative and polyacrylic acid through electrostatic interaction is used as a light capture antenna and an energy donor, and a fluorescent dye loaded on the supermolecular nano aggregate is used as an energy receptor. The light capture system provided by the invention has a wide color regulation and control range and remarkably enhanced active oxygen (including < 1 > O2 and O2) generation capability. Under the water phase condition, the light capture antenna of the system can enhance the generation of ROS, and after the fluorescent dye is loaded, the ROS is further enhanced.

The present invention relates to stilbene derivatives and a method for preparing the same. More particularly, the present invention relates to novel stilbene derivatives which inhibit the function of cyclophilins and are effective in preventing cyclophilin-related diseases or treating symptoms thereof, and a method for preparing the same.

The present disclosure provides stilbene derivatives and their preparation and use. Specifically, the present disclosure provides the use of a compound represented by Formula I-1, its stereoisomer, pharmaceutically acceptable salt, or prodrug as an aromatic hydrocarbon receptor (AHR) modulator. The compound represented by Formula I-1 has significantly improved photostability of its molecular structure compared to the commercially available drug benvitimod, thereby alleviating benvitimod's photoinstability and susceptibility to decomposition under light irradiation. Furthermore, it has significantly improved activity against the AHR protein. Finally, the compound represented by Formula I-1 can be produced by a simple method at gram or kilogram levels, and has better prospects for subsequent formulation development, safety, and clinical application. [Formula 1] JPEG2025533578000047.jpg26169

The present invention discloses a stilbene derivative and its preparation method and its application in the preparation of a medicine for treating psoriasis or ulcerative colitis, and belongs to the field of biomedicine technology. Its structural formula is as follows: Compound II 2 and II 23 provided by the present invention target and excite AHR related pathways, promote AHR to enter the nucleus, reduce the secretion of related cytokines at the cellular level, significantly improve imiquimod-induced mouse psoriasis model to obtain mouse skin symptoms and PASI scores, compared to the lead compound benvimod, its anti-psoriatic activity is better and less toxic, and it is found that compound II 23 can effectively treat mouse ulcerative colitis, reduce inflammatory response, and improve colitis symptoms. The compounds of the present invention can be used to prepare medicines for the treatment of psoriasis and ulcerative colitis.

The present invention relates to a photoisomerizable chiral hydrogel material, its preparation method, and application, belonging to the field of supramolecular materials. The photoisomerizable chiral hydrogel material is synthesized by modifying a symmetrical phenylalanine derivative with a stilbene derivative through a three-step liquid-phase reaction (amidation, trifluoroacetic acid deprotection, and amidation). The structural formula of the hydrogel material is shown as (I) or (II). The chirally uniform nanogel material prepared by the present invention successfully mimics the chiral helical structure of the extracellular microenvironment. The preparation method is simple, and the resulting hydrogel has excellent biocompatibility and can achieve damage-free three-dimensional encapsulation and photocontrolled release of cells. It has promising application prospects in fields such as controlled-release drug carriers and tissue engineering scaffold materials.

The present invention relates to an organic catalyst and a method for synthesizing a diphenylethylene derivative. The method for synthesizing the organic catalyst of the present invention comprises the following steps: reacting compound A with compound B to generate the organic catalyst. The organic catalyst prepared by the method for synthesizing the organic catalyst of the present invention has a high yield. At the same time, the method for synthesizing the organic catalyst of the present invention has simple steps, does not require harsh process conditions, and is suitable for large-scale production. The present invention provides a method for synthesizing an organic catalyst, and at the same time, uses the organic catalyst to synthesize a diphenylethylene derivative with simple raw materials under light conditions. In addition, the present invention provides a method for synthesizing a diphenylethylene derivative using the organic catalyst. The method does not require a transition metal catalyst, has no heavy metal residue, does not require high temperature and high pressure, and produces only water and nitrogen as by-products. The method is green and safe, and is particularly suitable for the synthesis of pharmaceutical and cosmetic active substances.