31 results about "Stilbenoid" patented technology

The present invention is a method for the biosynthesis of hundreds of compounds, mainly found in the cannabis plant. The starting material for these compounds can be any biological compound that is used/produced in a biological organism from the sugar family starting materials or other low cost raw materials processed via enzymes or within organisms to give final products. These final products include, but are not limited to: cannabinoids, terpenoids, stilbenoids, flavonoids, phenolic amides, lignanamides, spermidine alkaloids, and phenylpropanoids. Specifically, the present invention relates to the regular/modified/synthetic gene(s) of select enzymes are processed and inserted into an expression system (vector, cosmid, BAC, YAC, phage, etc.) to produce modified hosts. The modified host is then optimized for efficient production and yield via manipulation, silencing, and amplifying inserted or other genes in the host, leading to an efficient system for product.

The invention relates to a kind of ligustrazine derivant, preparation method and medicinal compound and its application, belonging to chuanxiong rhizome derivant medicine technique. The structure general formula is as that: Ar is hydroxybenzene, fluorophenyl, chlorphenyl, methylbenzene, methoxybenzene, nitrobenzene, cyanobenzene, furan group, ligustrazine or thiofuran. Said preparation method comprises following steps: mixing intermediate 2- chloromethyl- 3, 5, 6- trimethyl pyrazine and halogenated benzyl, triethyl phosphite; heating and refluxing, adding waterless tetrahydrofuran and NaH at tetrahydrofuran bath condition, dropping mixing solution of aromatic aldchyde and waterless tetrahydrofuran, stirring, extracting, drying, filtering, steaming to remove disslovant, separating residues with fast column chromatography, recrystallizing with methanol, and getting ligustrazine derivant. Said product and medical findings can be used to produce medicinal compound, and medicine for preventing angiocardiopathy and cerebrovascular diseases such as ischemic disease, atherosclerosis and coronary disease.

The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.

A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.

The invention discloses application of stilbenoids in a quorum sensing system for inhibiting chromobacterium violaceum. The stilbenoids comprise three stilbenoids, namely, resveratrol, piceatannol and oxyresveratrol. In the chromobacterium violaceum, generation of purple pigment is controlled by quorum sensing. The three stilbenoids of resveratrol, piceatannol and oxyresveratrol can all significantly inhibit quorum sensing of the chromobacterium violaceum under the sublethal concentration condition, namely, the condition without influencing growth of the chromobacterium violaceum, wherein the activity of resveratrol is the highest. The three stilbenoids of resveratrol, piceatannol and oxyresveratrol can be prepared into a quorum sensing inhibitor to the chromobacterium violaceum, can effectively inhibit quorum sensing and prevent bacteria infection and has an important practical value in clinic bacteriostasis application.

Improved methods for production of stilbenoids including resveratrol, pinosylvin and their respective derivatives are provided, including producing root cultures from plant cells and eliciting production of the stilbenes. The plant cells in an embodiment are contacted with substances which elicit production of the stilbenoid compounds.

A novel, bioavailable and safe stilbenoid 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 with an unexpected enhanced ability to prevent the accumulation of lipids accompanying the terminal differentiation of adipocytes, thereby inhibiting adipogenesis, and nutraceutical and cosmeceutical compositions comprising 3,5-dimethoxy-3,4′-dihydroxystilbene useful for anti-obesity and anti-cellulite therapy, are disclosed. Further the enhanced SIRT-1 activation ability of 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 and 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are disclosed. The enhancement of SIRT-1 polypeptide activity of the said compounds is unexpectedly much higher than resveratrol or its natural analog pterostilbene. Sirtuin modulating compositions comprising an orally bioavailable SIRT-1 enhancing compounds (i) 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#I and (ii) 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are also disclosed. An additional embodiment, also discloses the enhanced anti-Propionibacterium acnes activity of 3,5-dimethoxy-3,4′-dihydroxystilbenes represented by STR#I and compositions thereof.

The present invention relates to an antioxidatively active composition comprising at least one polyphenol-rich plant extract; at least one porphyrin; and at least one additional compound from the group of stilbenoids, and the use thereof.

The disclosed subject matter relates to the delivery of hydroxyl-containing compounds as microparticles for a variety of pharmaceutical, biomedical, cosmetics and personal care applications. This entails the manufacture and use of polymerized hydro-X compounds. Note is made of hydro-X compounds selected from the group consisting of curcuminoids, stilbenoids, resolvins, phenylethanoids, tocopherols, tocotrienols, flavanones, flavones, prenylflavonoids, isoflavones, isoflavanes, dihydrochalcones, isoflavenes, coumestans, lignans, flavonoligans, flavonols, mycoestrogens, xenoestrogens, phytoestrogens, sterols, corticosteroids, androgens, estrogens, stanols, steroids, secosteroids, tannins, statins, catechols, catechins, opioids, cannabinoids, pleuromutilins, luteolinidin, anthocyanidins, apigeninidin, glycosylated compounds, and macrolides.

A cis- or trans-stilbenoid of the general formula (1): in which each of R¹, R², R³, R⁴ and R⁵ is hydrogen or hydroxy, or a glycosylated or oligomeric form thereof, is produced by cultivating a micro-organism producing said stilbenoid, in a multi-phase system comprising at least an aqueous first phase containing said micro-organism and a second phase immiscible with said aqueous phase in which (e.g. as which) said stilbenoid accumulates. The second phase may be said stilbenoid or a free or encapsulated solvent compatible with the growth of the micro-organism, for instance an ester.

Aqueous solution, comprising, in dissolved state,—at least one stilbenoid—at least one saccharide, and method for increasing the solubility of a stilbenoid in water

The present invention relates generally to the treatment of virus infections. More specifically, the present invention relates to compositions and methods to treat rotavirus infections.

A composition for enhancing the self-dispersion and bioavailability of phytochemicals includes (i) phytochemicals selected from carotenoids, stilbenoid, isoflavones, terpenes, isoquinoline alkaloids, phenolic compounds, saponins, flavonoids, quinones, fatty acids and their derivatives; and (ii) bio-enhancing agents/self-dispersing agents derived from extract of fresh plant parts selected from Curcuma longa (Turmeric); Beta vulgaris (Beetroot), Solanum tuberosum (Potato), Aloe barbadensis (Aloe vera), Daucus carota (Carrot), Mangifera indica (Mango), Manihot esculenta (Tapioca) and Cocos nucifera (Coconut) and bulb of Allium sativum (garlic). A process for preparation of the composition is also disclosed herein.

The present invention relates to a skin-whitening and skin-protection composition that comprises stilbenoid (s) and/or stilbenoid-containing extract (s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the present invention further relates to the usage of Dendrobium ingredients and stilbenoids to reduce the formation of melanin in melanocytes. The present invention further relates to the usage of Dendrobium ingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and/or anti-skin aging products. Compounds for use in preparation of a composition for treating, preventing, and/or delaying the progress of skin darkening or for use in skin-whitening and skin-protection which are synthesized from dihydro-resveratrol and the related synthesis method are also provided.

Provided are a nerve growth inhibitor and a cutaneous-sensory-irritation inhibitor, with which dermal hyperesthesia and nerve extension based on newly found nerve extension mechanisms can be effectively inhibited. This nerve growth inhibitor or cutaneous-sensory-irritation inhibitor comprises one or more selected from: (1) a specific flavonoid; (2) a tannin; (3) chlorogenic acid; (4) a specific stilbenoid; and a glycoside or a pharmaceutically acceptable salt of (1)-(4); or (5) a specific crude drug extract; and (6) a walnut polyphenol.