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34 results about "Stilbenoid" patented technology
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Stilbenoids are hydroxylated derivatives of stilbene. They have a C₆–C₂–C₆ structure. In biochemical terms, they belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. Stilbenoids can be produced by plants and bacteria.
Novel Method for the cheap, efficient, and effective production of pharmaceutical and therapeutic api's intermediates, and final products
InactiveUS20160298151A1Reduce concentrationFermentationDNA/RNA fragmentationBiotechnologyPhenylpropanoid
The present invention is a method for the biosynthesis of hundreds of compounds, mainly found in the cannabis plant. The starting material for these compounds can be any biological compound that is used / produced in a biological organism from the sugar family starting materials or other low cost raw materials processed via enzymes or within organisms to give final products. These final products include, but are not limited to: cannabinoids, terpenoids, stilbenoids, flavonoids, phenolic amides, lignanamides, spermidine alkaloids, and phenylpropanoids. Specifically, the present invention relates to the regular / modified / synthetic gene(s) of select enzymes are processed and inserted into an expression system (vector, cosmid, BAC, YAC, phage, etc.) to produce modified hosts. The modified host is then optimized for efficient production and yield via manipulation, silencing, and amplifying inserted or other genes in the host, leading to an efficient system for product.
Owner:BUTT SHER ALI +1
Functionalized stilbene derivatives as improved vascular targeting agents
InactiveUS6919324B2Reduce or prevent retinal and corneal neovascularizationAvoid assemblyBiocideSenses disorderRetinal neovascularizationRetina
Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and combretastatin A-4. The prodrug forms serve as potent vascular targeting agents (VTAs) useful for the treatment of solid tumor cancers and diseases associated with retinal neovascularization.
Owner:BAYLOR UNIVERSITY +1
Functionalized stilbene derivatives as improved vascular targeting agents
Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and combretastatin A-4. The prodrug forms serve as potent vascular targeting agents (VTAs) useful for the treatment of solid tumor cancers and diseases associated with retinal neovascularization.
Owner:BAYLOR UNIVERSITY +1
Method for synthesizing stilbenoids by hydrochloric acid heterogeneous chlorination
The invention discloses a method for synthesizing stilbenoids of styrenemod, pterostilbene, piceatannol and resveratrol oxide by hydrochloric acid heterogeneous chlorination. The method takes substituted benzyl alcohol as a raw material, adopts hydrochloric acid for preparing chlorinated hydrocarbons under heterogeneous conditions and prepares the stilbenes compounds by Wittig-Horner condensation. The method is simple and easy to operate, the reactants involved in the synthesis process are safe, the products can not cause environmental pollution, the cost is low, and the yield is high, thereby being applicable to industrial production of styrenemod, pterostilbene, piceatannol and resveratrol oxide.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Ligustrazine stilbenoids derivatives, preparation method thereof, medicament composition and use
The invention relates to a kind of ligustrazine derivant, preparation method and medicinal compound and its application, belonging to chuanxiong rhizome derivant medicine technique. The structure general formula is as that: Ar is hydroxybenzene, fluorophenyl, chlorphenyl, methylbenzene, methoxybenzene, nitrobenzene, cyanobenzene, furan group, ligustrazine or thiofuran. Said preparation method comprises following steps: mixing intermediate 2- chloromethyl- 3, 5, 6- trimethyl pyrazine and halogenated benzyl, triethyl phosphite; heating and refluxing, adding waterless tetrahydrofuran and NaH at tetrahydrofuran bath condition, dropping mixing solution of aromatic aldchyde and waterless tetrahydrofuran, stirring, extracting, drying, filtering, steaming to remove disslovant, separating residues with fast column chromatography, recrystallizing with methanol, and getting ligustrazine derivant. Said product and medical findings can be used to produce medicinal compound, and medicine for preventing angiocardiopathy and cerebrovascular diseases such as ischemic disease, atherosclerosis and coronary disease.
Owner:SHANDONG UNIV
Stilbenoid derivatives and their uses
The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.
Owner:ARKANSAS STATE UNIVERSITY +1
Fusion proteins useful ln the production of cannabinoids
The present invention is a method for the biosynthesis of hundreds of compounds, mainly found in the cannabis plant. The starting material for these compounds can be any biological compound that is used / produced in a biological organism from the sugar family starting materials or other low cost raw materials processed via enzymes or within organisms to give final products. These final products include, but are not limited to: cannabinoids, terpenoids, stilbenoids, flavonoids, phenolic amides, lignanamides, spermidine alkaloids, and phenylpropanoids. Specifically, the present invention relates to the regular / modified / synthetic gene(s) of select enzymes are processed and inserted into an expression system (vector, cosmid, BAC, YAC, phage, etc.) to produce modified hosts. The modified host is then optimized for efficient production and yield via manipulation, silencing, and amplifying inserted or other genes in the host, leading to an efficient system for product.
Owner:CB THERAPEUTICS INC
Small molecular peptide composition of Dendrobium officinale Kimura et Migo as well as extraction method and application of small molecular peptide composition
InactiveCN105713944AReduce dosageReduce manufacturing costPeptide preparation methodsFermentationDipeptideComputational chemistry
The invention relates to an extraction method of small molecular peptide composition of Dendrobium officinale Kimura et Migo. The extraction method comprises steps as follows: (1), pretreatment of raw materials; (2), denaturation of Dendrobium officinale Kimura et Migo protein; (3), composite enzymatic hydrolysis of the Dendrobium officinale Kimura et Migo protein; (4), filtering and impurity removing; (5), dewatering and drying. The small molecular peptide composition of Dendrobium officinale Kimura et Migo contains small molecular peptides which are obtained through hydrolysis of the Dendrobium officinale Kimura et Migo protein, the molecular weight of the small molecular peptides is mainly distributed in a range from 100 D to 700 D, and the small molecular peptide composition further contains polysaccharide, dendrobine, amino acid, stilbenoid, stilbenoid derivatives, vitamins and trace substances and can be applied to medicine raw materials, healthcare food and cosmetics. The molecular weight of a product is mainly distributed in a range from 100 D to 700 D, most of the obtained small molecular peptides are in micromolecular structures such as dipeptides, tripeptides, tetrapeptides and the like which are quite easily absorbed by a human body, and the small molecule peptides with the molecular weight distributed in 60-700 D accounts for 90% or higher of the total weight of the protein.
Owner:蔡庭守
Skin-protection composition containing dendrobium-based ingredients
A skin-protection composition is shown that comprises stilbenoid(s) and / or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and / or anti-skin aging products.
Owner:HONG KONG BAPTIST UNIV
Application of stilbenoids in quorum sensing system for inhibiting chromobacterium violaceum
InactiveCN106074466AInhibit synthesisInhibitionAntibacterial agentsBiocideOxyresveratrolMicrobiology
The invention discloses application of stilbenoids in a quorum sensing system for inhibiting chromobacterium violaceum. The stilbenoids comprise three stilbenoids, namely, resveratrol, piceatannol and oxyresveratrol. In the chromobacterium violaceum, generation of purple pigment is controlled by quorum sensing. The three stilbenoids of resveratrol, piceatannol and oxyresveratrol can all significantly inhibit quorum sensing of the chromobacterium violaceum under the sublethal concentration condition, namely, the condition without influencing growth of the chromobacterium violaceum, wherein the activity of resveratrol is the highest. The three stilbenoids of resveratrol, piceatannol and oxyresveratrol can be prepared into a quorum sensing inhibitor to the chromobacterium violaceum, can effectively inhibit quorum sensing and prevent bacteria infection and has an important practical value in clinic bacteriostasis application.
Owner:NANJING UNIV OF SCI & TECH
Botanical antioxidant compositions and methods of preparation and use thereof
ActiveUS9326932B2Prevent damage to skinBroad protectionCosmetic preparationsToilet preparationsAntioxidantIsoflavones
A botanical antioxidant composition includes a botanical antioxidant extract blend including a first antioxidant botanical extract including at least one hydroxycinnamic acid, and at least one additional antioxidant botanical extracts including at least one antioxidant selected from the group consisting of vitamins, stilbenoids, curcumininoids, tannins, flavones, flavonols, flavan-3-ols, flavanones, anthocyanidins, anthocyanins, isoflavones, flavanonols, proanthocyanidins, dihydroxybenzoic acids, and pyridine alkaloids.
Owner:DERMAFORCE HLDG LLC
Microbial bioreaction process
A cis- or trans-stilbenoid of the general formula (1): in which each of R1, R2, R3, R4 and R5 is hydrogen or hydroxy, or a glycosylated or oligomeric form thereof, is produced by cultivating a micro-organism producing said stilbenoid, in a multi-phase system comprising at least an aqueous first phase containing said micro-organism and a second phase immiscible with said aqueous phase in which (e.g. as which) said stilbenoid accumulates. The second phase may be said stilbenoid or a free or encapsulated solvent compatible with the growth of the micro-organism, for instance an ester.
Owner:EVOLVA SA
Production of stilbenes in plant hairy root cultures and other root cultures
InactiveUS20100130623A1Increase volumeBiocideHydroxy compound active ingredientsBiotechnologyPlant cell
Improved methods for production of stilbenoids including resveratrol, pinosylvin and their respective derivatives are provided, including producing root cultures from plant cells and eliciting production of the stilbenes. The plant cells in an embodiment are contacted with substances which elicit production of the stilbenoid compounds.
Owner:ARKANSAS STATE UNIV RES & DEV INST
Orally bioavailable stilbenoids- compositions and therapeutic applications thereof
InactiveUS20100204340A1Enhanced ability to preventInhibit lipogenesisBiocideOrganic chemistryAdipogenesisCosmeceuticals
A novel, bioavailable and safe stilbenoid 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 with an unexpected enhanced ability to prevent the accumulation of lipids accompanying the terminal differentiation of adipocytes, thereby inhibiting adipogenesis, and nutraceutical and cosmeceutical compositions comprising 3,5-dimethoxy-3,4′-dihydroxystilbene useful for anti-obesity and anti-cellulite therapy, are disclosed. Further the enhanced SIRT-1 activation ability of 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 and 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are disclosed. The enhancement of SIRT-1 polypeptide activity of the said compounds is unexpectedly much higher than resveratrol or its natural analog pterostilbene. Sirtuin modulating compositions comprising an orally bioavailable SIRT-1 enhancing compounds (i) 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#I and (ii) 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are also disclosed. An additional embodiment, also discloses the enhanced anti-Propionibacterium acnes activity of 3,5-dimethoxy-3,4′-dihydroxystilbenes represented by STR#I and compositions thereof.
Owner:SAMI LABS LTD
Antioxidatively active composition and the use thereof
InactiveCN105188722AOrganic active ingredientsInorganic phosphorous active ingredientsChemical compoundPorphyrin
The present invention relates to an antioxidatively active composition comprising at least one polyphenol-rich plant extract; at least one porphyrin; and at least one additional compound from the group of stilbenoids, and the use thereof.
Owner:LR HEALTH & BEAUTY SYST
Microparticle Enabled Delivery Structures, Methods of Preparing and Using Same
InactiveUS20170224632A1Protect propertyCosmetic preparationsPowder deliveryPersonal careLuteolinidin
The disclosed subject matter relates to the delivery of hydroxyl-containing compounds as microparticles for a variety of pharmaceutical, biomedical, cosmetics and personal care applications. This entails the manufacture and use of polymerized hydro-X compounds. Note is made of hydro-X compounds selected from the group consisting of curcuminoids, stilbenoids, resolvins, phenylethanoids, tocopherols, tocotrienols, flavanones, flavones, prenylflavonoids, isoflavones, isoflavanes, dihydrochalcones, isoflavenes, coumestans, lignans, flavonoligans, flavonols, mycoestrogens, xenoestrogens, phytoestrogens, sterols, corticosteroids, androgens, estrogens, stanols, steroids, secosteroids, tannins, statins, catechols, catechins, opioids, cannabinoids, pleuromutilins, luteolinidin, anthocyanidins, apigeninidin, glycosylated compounds, and macrolides.
Owner:UNIV OF KENTUCKY RES FOUND
Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions
A polyphenol derivative of the stilbenoid family, namely trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
Owner:HONG KONG BAPTIST UNIV
Microbial Bioreaction Process
InactiveUS20130344571A1Without reduction of hydroxystilbene yieldFermentationMicrobiology processesMicroorganismHydrogen
A cis- or trans-stilbenoid of the general formula (1): in which each of R1, R2, R3, R4 and R5 is hydrogen or hydroxy, or a glycosylated or oligomeric form thereof, is produced by cultivating a micro-organism producing said stilbenoid, in a multi-phase system comprising at least an aqueous first phase containing said micro-organism and a second phase immiscible with said aqueous phase in which (e.g. as which) said stilbenoid accumulates. The second phase may be said stilbenoid or a free or encapsulated solvent compatible with the growth of the micro-organism, for instance an ester.
Owner:EVOLVA SA
Mineral sunscreen compositions with improved efficacy
ActiveUS10813870B2Reduce whitenessEnhanced SPFCosmetic preparationsToilet preparationsDIETHYLHEXYL SYRINGYLIDENEMALONATEMalonic acid
Mineral sunscreen compositions having improved efficacy are described. The mineral sunscreen compositions include: (a) one or more mineral UV filtering agents; (b) one or more stilbenoids; (c) ethylhexylmethoxycrylene. (d) diethylhexyl syringylidenemalonate; and (e) a cosmetically acceptable carrier. The mineral sunscreen compositions provide a high sun protection factor (SPF) without requiring high amounts of mineral UV filtering agents. Also, the mineral sunscreen compositions are less opaque and white than traditional mineral sunscreen compositions making them aesthetically appealing to consumers.
Owner:LOREAL SA
Ligustrazine stilbenoids derivatives, preparation method thereof, medicament composition and use
Owner:SHANDONG UNIV
Microbial bioreaction process
ActiveUS20100203603A1Avoid toxicityWithout reduction of hydroxystilbene yieldBacteriaFermentationHydrogenSolvent
A cis- or trans-stilbenoid of the general formula (1): in which each of R1, R2, R3, R4 and R5 is hydrogen or hydroxy, or a glycosylated or oligomeric form thereof, is produced by cultivating a micro-organism producing said stilbenoid, in a multi-phase system comprising at least an aqueous first phase containing said micro-organism and a second phase immiscible with said aqueous phase in which (e.g. as which) said stilbenoid accumulates. The second phase may be said stilbenoid or a free or encapsulated solvent compatible with the growth of the micro-organism, for instance an ester.
Owner:EVOLVA SA
Stilbenoid derivatives and their uses
The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.
Owner:ARKANSAS STATE UNIV +1
Stilbenoid Derivatives And Their Uses
The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.
Owner:ARKANSAS STATE UNIV +1
Aqueous solution comprising a polyphenol
ActiveUS11185514B2Improve stabilityAlter stability and solubilityHydroxy compound active ingredientsPharmaceutical delivery mechanismSolubilityPolyphenol
Aqueous solution, comprising, in dissolved state,—at least one stilbenoid—at least one saccharide, and method for increasing the solubility in water.
Owner:OPTERION HEALTH AG
Aqueous solution comprising a polyphenol
InactiveUS20180214387A1Improve solubilityImprove stabilityHydroxy compound active ingredientsPharmaceutical delivery mechanismSolubilityAqueous solution
Aqueous solution, comprising, in dissolved state,—at least one stilbenoid—at least one saccharide, and method for increasing the solubility of a stilbenoid in water
Owner:OPTERION HEALTH AG
5-phenyl isoxazole-containing stilbenoid compound and preparation method thereof
ActiveCN106117156AAchieving the goal of lowering blood sugarOrganic chemistryMetabolism disorderFormateTyrosine
The invention relates to a 5-phenyl isoxazole-containing stilbenoid compound (I) and a preparation method thereof. The preparation method comprises the following steps: condensing methyl 4'-hydroxy stilbene-3-formate (II) and 5-phenyl-3-chloromethyl isoxazole (III), and further performing hydrolysis and acidification to obtain the 5-phenyl isoxazole-containing stilbenoid compound. The 5-phenyl isoxazole-containing stilbenoid compound I has inhibitory activity on protein tyrosine phosphatase-1B (PTP1B), and can be used for preparing hypoglycemic drugs.
Owner:东营睿港招商服务有限责任公司
Therapeutic Applications Of Prenylated Stilbenoids Against Rotavirus Infections
InactiveUS20160346226A1Many symptomSufficient effectHydroxy compound active ingredientsPharmaceutical delivery mechanismViral infectionRotavirus Infections
Owner:STEPHEN F AUSTIN STATE UNIV +1
Composition for enhancement of bioavailability of phytochemicals and process for preparation thereof
A composition for enhancing the self-dispersion and bioavailability of phytochemicals includes (i) phytochemicals selected from carotenoids, stilbenoid, isoflavones, terpenes, isoquinoline alkaloids, phenolic compounds, saponins, flavonoids, quinones, fatty acids and their derivatives; and (ii) bio-enhancing agents / self-dispersing agents derived from extract of fresh plant parts selected from Curcuma longa (Turmeric); Beta vulgaris (Beetroot), Solanum tuberosum (Potato), Aloe barbadensis (Aloe vera), Daucus carota (Carrot), Mangifera indica (Mango), Manihot esculenta (Tapioca) and Cocos nucifera (Coconut) and bulb of Allium sativum (garlic). A process for preparation of the composition is also disclosed herein.
Owner:OLENE LIFE SCI PTE LTD
Skin-protection composition containing dendrobium-based ingredients
The present invention relates to a skin-whitening and skin-protection composition that comprises stilbenoid (s) and / or stilbenoid-containing extract (s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the present invention further relates to the usage of Dendrobium ingredients and stilbenoids to reduce the formation of melanin in melanocytes. The present invention further relates to the usage of Dendrobium ingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and / or anti-skin aging products. Compounds for use in preparation of a composition for treating, preventing, and / or delaying the progress of skin darkening or for use in skin-whitening and skin-protection which are synthesized from dihydro-resveratrol and the related synthesis method are also provided.
Owner:HONG KONG BAPTIST UNIV
Aqueous solution comprising a polyphenol
ActiveUS20200108026A1Improve stabilityAlter stability and solubilityHydroxy compound active ingredientsPharmaceutical delivery mechanismSolubilityPolyphenol
Aqueous solution, comprising, in dissolved state,—at least one stilbenoid—at least one saccharide, and method for increasing the solubility in water.
Owner:OPTERION HEALTH AG
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