Novel Method for the cheap, efficient, and effective production of pharmaceutical and therapeutic api's intermediates, and final products

a technology of api and intermediates, applied in the field of large-scale production of pharmaceuticals and supplemental products, can solve the problems of very low concentration of cannabis cannabinoids

Inactive Publication Date: 2016-10-13
BUTT SHER ALI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]The most important advantage of the present invention is that we can make and use many compounds that are virtually so low in concentration in the cannabis plant, that there is no effect in using cannabis if we are only after the therapeutic effects of these compounds. For example, patients using marijuana can only benefit from tetrahydrocannabinolic acic (THCA), THC, cannabidiolic acid (CBDA), CBD, CBN, and a few other compound class families, as the concentrations of the other compounds is so low that it has no effect. This invention will allow the production of hundreds of compounds in pure form, leading to many new medical discoveries and applications.
[0009]The nature, objects, and advantages of the present invention will become more apparent to those skilled in the art after considering the following detailed description in connection with the accompanying figures, in which like reference numerals designate like parts throughout, and wherein:
[0010]FIG. 1 is a diagram of the pathway for the biosynthesis of all molecules of interest via the conversion of starting materials to glucose and then to final products;
[0011]FIG. 2 is a diagram of the pathway for the biosynthesis of cannabinoids;
[0012]FIG. 3 is a diagram of the pathway for the biosynthesis of stilbenoids;
[0013]FIG. 4 is a diagram of the pathway for the biosynthesis of phenylpropanoids and flavonoids;

Problems solved by technology

However, most of various types of cannabinoids in cannabis are at a very low concentration in the plant.

Method used

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  • Novel Method for the cheap, efficient, and effective production of pharmaceutical and therapeutic api's intermediates, and final products
  • Novel Method for the cheap, efficient, and effective production of pharmaceutical and therapeutic api's intermediates, and final products
  • Novel Method for the cheap, efficient, and effective production of pharmaceutical and therapeutic api's intermediates, and final products

Examples

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example

Bacterial

[0095]Bacteria (E. Coli, etc.) are inserted with exp. system giving us a modified host. The mod host can either be further processed or it can generate products. Products / intermediates are made in the host, and may be either enzymes that are further extracted and used in vitro, or we add substrates into the bacterial culture so they use the enzymes produced in them to make the substrate. Either way (protein or prod production), purification is carried out to get final products, or intermediates that can be further processed in vitro to give final products. Throughout this procedure, host engineering can be carried out at any step of any process to get better yields.

example 2

Plants

[0096]Plant tissue can be used as a starting material to get a tissue culture going. Appropriate expression vectors / systems carry our interest genes into the cells. Alternatively, cell engineering can lead to many combinations that may have similar or different outcomes. The culture can be grown into full plants, and products are ingested by consuming the plants (e.g. tomatoes with certain cannabinoids produced within, etc.). The second way uses the cell culture in a synthetic environment to produce final products / intermediates. Finally, product is purified and used.

example 3

Algae

[0097]Algae are modified with the usual techniques used for host engineering. Once completed, the mod host can be embedded into a system similar to biofuel production from algae. Using sunlight and some nutrients, the algae produces final products / intermediates, which is appropriately filtered from the bulk. Other products generated can be further processed to get biofuels or other important compounds that can readily be sold in the market.

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Abstract

The present invention is a method for the biosynthesis of hundreds of compounds, mainly found in the cannabis plant. The starting material for these compounds can be any biological compound that is used/produced in a biological organism from the sugar family starting materials or other low cost raw materials processed via enzymes or within organisms to give final products. These final products include, but are not limited to: cannabinoids, terpenoids, stilbenoids, flavonoids, phenolic amides, lignanamides, spermidine alkaloids, and phenylpropanoids. Specifically, the present invention relates to the regular/modified/synthetic gene(s) of select enzymes are processed and inserted into an expression system (vector, cosmid, BAC, YAC, phage, etc.) to produce modified hosts. The modified host is then optimized for efficient production and yield via manipulation, silencing, and amplifying inserted or other genes in the host, leading to an efficient system for product.

Description

RELATED APPLICATIONS[0001]The present application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 62 / 145,430, entitled “A Novel Method for the Cheap, Efficient, and Effective Production of Pharmaceutical and Therapeutic API's, Intermediate, and Final Products”, filed Apr. 9, 2015, and currently co-pending.FIELD OF THE INVENTION[0002]The present invention is in the technical field of large scale production of pharmaceutical and supplemental products for various common illnesses, medical conditions, and general industrial use. More particularly, the present invention is in the technical field of bio-synthesis of cannabinoids, terpenoids, stilbenoids, flavonoids, phenolic amides, lignanamides, spermidine alkaloids, and phenylpropanoids; compounds found in cannabis sativa, along with various combinations and specialized formulations which are beneficial in ailments ranging from cancer to glaucoma. The final product(s) can be an intermediate or a compound o...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12P13/02C12P7/22C12P13/00C12P17/06
CPCC12P13/02C12P13/001C12P7/22C12P17/06C12P7/42C12N15/52
Inventor BUTT, SHER ALIVOGAN, JACOB MICHAEL
Owner BUTT SHER ALI
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