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Antioxidatively active composition and the use thereof

A technology of antioxidant activity and composition, applied in the direction of active ingredients of phosphorus compounds, drug combinations, organic active ingredients, etc., can solve the problems of increasing antioxidants, disadvantages, etc.

Inactive Publication Date: 2015-12-23
LR HEALTH & BEAUTY SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Increased free radical load in smokers against unfavorable supply of antioxidants

Method used

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  • Antioxidatively active composition and the use thereof
  • Antioxidatively active composition and the use thereof
  • Antioxidatively active composition and the use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] A preferred embodiment of the composition according to the invention has the contents listed in Table 1.

[0064]

[0065]

[0066] Table 1 : Contents of one embodiment of the composition according to the invention.

Embodiment 2

[0068] The determination of the ORAC value of the composition according to Example 2 was carried out in the following manner.

[0069] The basis of the measurement principle based on ORAC measurement is that free radicals (currently 2,2'-azobisisobutylamidine dihydrochloride, 2,2'-Azobis(2-Amidinopropan) dihydrochlorid, AAPH) decompose the fluorescent The total fluorescence of the molecule (currently fluorescein) and thus the sample decreases. The changes are used to demonstrate damage caused by free radicals. The addition of an antioxidant inhibits the damage and maintains the fluorescence. The vitamin E derivative Trolox was used as a benchmark, therefore the results are stated in Trolox equivalents.

[0070] To prepare the samples, first 1 mL of the sample was dissolved in 2.5 mL of acetone-water mixture (50:50, v / v) and diluted to 10 mL with distilled water (dilution ratio 1:10).

[0071] The fluorescein working solution was prepared by dilution of the stock solution (c...

Embodiment 3

[0074] A user test was performed to investigate the antioxidant effect of the composition of Example 1.

[0075] The requirement for antioxidant supplementation in prophylaxis can be determined via selected markers correlated with the degree of oxidative stress in urine or in blood / serum / plasma. The selection of the subjects in the user test is therefore based on the use of creatinine and isoprostane in the urine and / or lipid peroxides in the blood.

[0076] With the help of this study, it was investigated whether and to what extent antioxidants delivered in the current composition, which have been shown to be effective in the blood or urine of healthy, adult subjects, were taken in addition to normal food High ORAC values ​​that have an effect on markers of oxidative stress, the subject has increased markers of oxidative stress in blood or urine, namely: lipid peroxide in blood and isoprostanes in urine. It should also be confirmed what role the magnitude of the raw value of...

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Abstract

The present invention relates to an antioxidatively active composition comprising at least one polyphenol-rich plant extract; at least one porphyrin; and at least one additional compound from the group of stilbenoids, and the use thereof.

Description

technical field [0001] The present invention relates to a composition with antioxidant activity according to claim 1 and to the use of said composition according to claim 17 . Background technique [0002] Antioxidants are of great physiological importance due to their role as free radical scavengers. Antioxidants inactivate reactive oxygen species (ROS) in living organisms, the excess presence of which leads to oxidative stress. Oxidative stress is thought to be jointly responsible for the aging process and has been linked to the development of a range of diseases. [0003] Oxidation and reduction are important biochemical reactions in human cells. Unstable, highly reactive and transient species such as oxygen radicals act as intermediates. Free radicals are understood to be atoms, ions or molecules having one or more unpaired electrons in the outer electron shell. The unpaired electrons strive to pair with other electrons and are therefore highly reactive. Oxygen meta...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K31/409A61K36/82A61K36/87A61K36/704A61K36/185A61K36/38A61K36/48
CPCA61K36/82A61K31/409A61K36/185A61K36/38A61K36/48A61K36/704A61K33/42A61K36/87A61P39/06A61K2300/00A61K31/015A61K2121/00A61K36/886
Inventor 萨拜因·拉森-韦弗林克里斯蒂安·朗济安莫妮卡·加森
Owner LR HEALTH & BEAUTY SYST
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