Use of benserazide as an antibacterial agent

An antibacterial agent, benserazide technology, applied in the field of antibacterial preparation research and development, can solve the problem of limited treatment methods for CRKP, and achieve the effect of solving bacterial infection

Active Publication Date: 2021-08-03
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing studies have shown that CRKP drug resistance is mainly due to the production of carbapenemase by the strain, which can efficiently hydrolyze penicillin, cephalosporin, aztreonam and carbapenem antibiotics. limited

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of benserazide as an antibacterial agent
  • Use of benserazide as an antibacterial agent
  • Use of benserazide as an antibacterial agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1BZ

[0060] The in vitro action determination of embodiment 1BZE anti-drug-resistant bacteria

[0061] 1. Materials

[0062] 1.1 Experimental strains

[0063] Two MRSA strains, two MDRAB strains, and two CRKP strains were isolated and identified by the Microbiology Laboratory of Qilu Children's Hospital of Shandong University.

[0064] 1.2 Drugs and main reagents

[0065] Benserazide (BZE), Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai);

[0066] Calcium-adjusted MH Broth Medium (CAMHB), Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0067] MHA agar medium, Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0068] Normal saline, Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai).

[0069] 1.3 Instruments

[0070] Electronic balance (AUY120), SHIMADZU CORPORATION (Japan);

[0071] Bacteria collection ring, Huanyao Pharmaceutical Equipment Sales Co., Ltd. (Beijing, China);

[0...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention specifically relates to the use of BZE as an antibacterial agent. In view of the current situation that drug-resistant bacteria are increasing year by year, and the research and development cycle of antibacterial drugs is long, and the speed of marketing is slow, this field develops non-antibiotic drugs with antibacterial effects to deal with the difficult situation that drug-resistant bacteria are difficult to treat. Based on this technical idea, the present invention screens and verifies that BZE has a good antibacterial effect, and has a good in vitro complete inhibitory effect on MRSA, MDRAB and CRKP with high drug resistance. Based on the results of this study, BZE is expected to be developed as an active ingredient of a broad-spectrum antibacterial drug, which has good clinical and economic significance.

Description

technical field [0001] The invention belongs to the technical field of research and development of antibacterial preparations, and in particular relates to the application of benserazide as an antibacterial active ingredient in the preparation of antibacterial preparations. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Benserazide (benserazide, BZE) is a peripheral dopa decarboxylase inhibitor. Generally, benserazide and levodopa are used in combination for Parkinson's disease and Parkinson's syndrome. The pharmacological effect of benserazide is similar to that of carbidopa, and it is difficult to penetrate the blood-cerebrospinal fluid barrier. It is absorbed quickly...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/165A61P31/04A01N37/36A01P1/00
CPCA01N37/36A61K31/165A61P31/04A61K2300/00
Inventor 李秀云张运奎郝丽娜
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products