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Application of benserazide and its composition with fluconazole in the preparation of antifungal products

A technology of benserazide and antifungal, which is applied in the field of preparation of antifungal products, to achieve the effect of improving economic value and enriching the purpose of clinical use

Active Publication Date: 2021-06-04
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Azoles are currently the main antifungal drugs used clinically. Among them, fluconazole is safe, effective and inexpensive, and is widely used clinically. However, the continuous emergence of drug resistance makes it urgent to find new antifungal means

Method used

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  • Application of benserazide and its composition with fluconazole in the preparation of antifungal products
  • Application of benserazide and its composition with fluconazole in the preparation of antifungal products
  • Application of benserazide and its composition with fluconazole in the preparation of antifungal products

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Embodiment 1

[0056] 1. Materials

[0057] 1.1 Drugs and reagents

[0058] Fluconazole (FLC), Dalian Meilun Biotechnology Co., Ltd.;

[0059] Benserazide (Benserazide, BEH), Dalian Meilun Biotechnology Co., Ltd.;

[0060] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0061] TTC-Sa Paul medium, Qingdao Hi-tech Park Haibo Biotechnology Co., Ltd.;

[0062] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0063] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0064] Glucose, Beijing Dingguochangsheng Biotechnology Co., Ltd.;

[0065] Agar powder, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0066] PBS phosphate buffer, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0067] Sodium hydroxide, state-owned Shandong Shanxian Organic Chemical Factory, batch number 940420;

[0068] Potassium dihydrogen phosphate, Shanghai Xinbao Fine Chemical Factory, batch number 200602132;

[0069] RPMI 1640 API powder, American GIBCO c...

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Abstract

The invention specifically relates to the application of benserazide and its composition with fluconazole in the preparation of antifungal products. In recent years, the rate of fungal infection and the resulting mortality have shown an upward trend, among which Candida is the most serious threat to the body. At present, azole drugs are the first-line drugs for antifungal treatment, but the treatment effect is not satisfactory due to the continuous emergence of drug-resistant bacteria. Aiming at the current situation, the present invention provides the antifungal effect of benserazide, which enriches the compound entities with antifungal effect. Further, the research of the present invention also shows that benserazide can cooperate with fluconazole to treat Candida albicans, Gram The more harmful Candida such as Candida tenida and Candida glabrata have a good inhibitory effect, improve the drug sensitivity of drug-resistant strains, and reduce the dosage of drugs.

Description

technical field [0001] The invention belongs to the technical field of antifungal drugs, and in particular relates to the application of benserazide and a pharmaceutical composition composed of benserazide and fluconazole in the preparation of antifungal products. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] In recent years, due to the use of broad-spectrum antibiotics, the development of techniques such as organ transplantation and indwelling catheters, and the increase in cancer radiotherapy and chemotherapy, the number of immunocompromised patients has continued to increase, and the rate of deep fungal infections has increased significantly. Despite the treatment of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/165A61K45/06A61K31/4196A61P31/10
CPCA61K31/165A61K31/4196A61K45/06A61P31/10A61K2300/00
Inventor 孙淑娟陈雪琪鲁春燕闫海英任洪耀
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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