50 results about "Paeoniae Radix" patented technology

A traditional Chinese medicine composition for treating pulmonary nodules, wherein the composition is prepared from the following traditional Chinese medicines in parts by weight: a principle drug selected from one or more of 10-45 parts of raw Astragali radix, 10-25 parts of Sargassum, and 10-25 parts of Arisaematis rhizoma preparatum; a minister drug selected from one or more of 10-25 parts of Fritillariae thunbergii bulbus, 10-25 parts of Forsythiae fructus, 10-25 parts of stir-fried Atractylodis macrocephalae rhizoma, 1T0 part of Hirudo, 10-25 parts of Dioscoreae nipponicae rhizoma, 10-35 parts of Adenophorae radix, 10-35 parts of honey-processed Mori cortex, 10-25 parts of Perillae fructus, 10-25 parts of Peucedani radix, 10-35 parts of Phragmitis rhizome, 10-45 parts of raw Coicis semen, 5-25 parts of vinegar-processed Cyperi rhizoma, 10-25 parts of Aurantii fructus, 10-25 parts of Paeoniae radix alba, 10-35 parts of Scutellariae barbatae herba, 10-35 parts of Herba duchesneae indicae, 10-35 parts of Salviae chinensis herba, 5-20 parts of Menispermi rhizoma, 5-20 parts of Momordicae semen, 10-25 parts of Curcumae rhizoma, and 5-20 parts of Gleditsiae spina; an assistant drug selected from one or more of 5-25 parts of vinegar-processed Bupleuri radix, 5-25 parts of Citri reticulatae pericarpium, 10-25 parts of Perillae fructus, 2-12 parts of processed Ephedrae herba, 10-25 parts of Cynanchi stauntonii rhizoma et radix, 5-20 parts of Typhonii rhizoma, 2-12 parts of Zingiberis rhizoma, 10-35 parts of Morindae officinalis radix, 10-35 parts of Scutellariae barbatae herba, 10-45 parts of Radix aconiti lateralis praeparata nigra, and 10-25 parts of Typhonii rhizoma praeparata; and an envoy drug selected from one or more of 5-20 parts of Fagopyri dibotryis rhizoma, 10-25 parts of Platycodonis radix, 10-25 parts of Paeoniae radix alba, and 5-25 parts of Glycyrrhizae radix et rhizoma praeparata cum melle.

The invention provides traditional Chinese medicine powder for improving the transfer survival rate of yellow fin tuna, which is prepared by weighing the following components in percentage by mass: 15-20% of radix bupleuri, 10-15% of radix puerariae, 15-20% of liquorice, 5-10% of Chinese herbaceous peony, 5-10% of blackberry lily, 5-10% of fructus forsythiae, 5-10% of poria cocos, 5-10% of rhizoma anemarrhenae, 5-10% of pericarpium citri reticulatae and 20-25% of gypsum, totaling 100%. All the materials pass through a 200-mesh screen and are uniformly mixed to obtain the traditional Chinese medicine powder for improving the transfer survival rate of the yellow fin tuna. The traditional Chinese medicine powder takes common Chinese herbal medicines as main raw materials, has the characteristics of rich resources, wide raw material sources, easiness in obtaining and the like, is free of toxic and side effects, free of hormones, difficult to pollute the environment, free of residues in the bodies of the yellow fin tunas, safe to use, simple to operate, low in cost and suitable for popularization, and has a wide application prospect. The survival rate of the yellow fin tuna in the transportation process can be increased, the immunity of the fish body can be adjusted, and the anti-stress capability of the fish body is enhanced.

The invention relates to a method for extracting paeonol and paeoniflorin from fresh radix paeoniae rubra. The method comprises the following specific steps: washing and mincing the fresh radix paeoniae rubra, extracting with diethyl ether, performing alcohol extraction and water extraction, filtering, concentrating, performing alcohol precipitation, crystallizing and recrystallizing to obtain pure paeonol and paeoniflorin products. According to the method disclosed by the invention, diethyl ether extraction is adopted, so that not only is the enzyme activity of the fresh peony accelerated to be damaged, but also the risk that paeonol is oxidized is reduced, the leaching speed of paeonol is increased, the utilization efficiency of the fresh peony is greatly improved, the drying step of the fresh peony is effectively reduced, and the production energy consumption during extraction processing is saved; the dissolution and volatilization characteristics of paeonol are fully considered, diethyl ether removal and paeonol volatilization are carried out by utilizing different temperature gradients, and refining is carried out to obtain a pure paeonol product.

The invention discloses a composition for inhibiting bacteria, resisting inflammation, relieving inflammation and repairing sensitive skin. The composition comprises the following components in parts by weight: 1-5 parts of a sophora flavescens extract; 2-15 parts of a radix scutellariae extract; 5-10 parts of a white peony root extract; 0.2 to 5 parts of a grapefruit extract; and 1-5 parts of pomegranate extract. The composition prepared from the radix sophorae flavescentis extract, the radix scutellariae extract, the radix paeoniae alba extract, the grapefruit extract and the pomegranate extract takes sophocarpidine, baicalin, paeoniflorin, naringin and punicalagin as main functional components to play a synergistic effect, so that the composition has very remarkable effects of inhibiting bacteria, resisting inflammation, relieving inflammation and repairing sensitive skin.

Application of total monoterpene glycosides of Paeonia veitchii Lynch and analysis method for active ingredients in total monoterpene glycosides of Paeonia veitchii Lynch. For the first time, the UPLC-MS / MS technology is adopted in the present invention to establish the fingerprint of total monoterpene glycosides of Paeonia veitchii Lynch from 11 batches of different producing areas, laying a foundation for revealing the effective ingredient group of total monoterpene glycosides of Paeonia veitchii Lynch. Five compounds with muscle-building effects mainly composed of total monoterpene glycosides of Paeonia veitchii Lynch are determined in the present invention, including 4 monoterpene glycoside compounds, and one belongs to the isomer of benzoylpaeoniflorin. Application of total monoterpene glycosides of Paeonia veitchii Lynch in preparing animal feed or medicine for increasing muscle. The present invention establishes a fingerprint-pharmacodynamic correlation model of total monoterpene glycosides of Paeonia veitchii Lynch. While establishing the quality evaluation standard for muscle-building effects based on the fingerprint of the effective part of total monoterpene glycosides of Paeonia veitchii Lynch, it also provides a new idea for screening active ingredients of other pharmacological effects of Paeonia veitchii Lynch. The present invention lays a theoretical foundation for the development of muscle-building foods for fitness people and provides new resources for the development of animal feed additives in animal husbandry.

The present invention relates to a composition for enhancing immunity, containing Cheongwi-san as an active ingredient. The Cheongwi-san of the present invention is a mixed herbal medicine extract consisting of Cimicifuga heracleifolia, Moutan Radicis Cortex, Angelica gigas, Coptis Rhizome, and fresh root of Rehmannia glutinosa. The Cheongwi-san of the present invention has excellent effects of increasing the activity of NK cells, increasing the production amounts of IFN-γ and TNF-α, and reducing the survival rate of cancer cells, and has the effect of inhibiting influenza virus infection, and thus can be effectively used as a health functional food for enhancing immunity, a feed additive for animals for enhancing immunity, or a pharmaceutical product for preventing and treating diseases caused by decreased immunity.

Provided is a traditional Chinese herbal composition for treating pulmonary nodules, a preparation method thereof, and a honeyed pill. The composition comprises: 30 parts by weight of Ziziphi Spinosae Semen, 20-30 parts by weight of Rehmaniae Radix, 30 parts by weight of Trichosanthis Radix, 40-50 parts by weight of Paeoniae Radix Alba, 30 parts by weight of Coicis Semen Preparata, 20 parts by weight of Ginseng Radix et Rhizoma, 10 parts by weight of Olibanum, 10 parts by weight of Myrrha, 20-30 parts by weight of Testudinis Carapax et Plastrum Preparata Cum Aceto, 20-30 parts by weight of Trionycis Carapax Preparata Cum Aceto, 30 parts by weight of Agrimoniae Herba, 10-20 parts by weight of Alpiniae Oxyphyllae Fructus, 5 parts by weight of Toosendan Fructus, 20 parts by weight of Poria, 10 parts by weight of Platycodonis Radix, and 10 parts by weight of Polygalae Radix.

Provided are a skin care active substance and a skin care product. The skin care active substance comprises, in part by weight: 0.1-15 parts of a humectant and 0.05-2 parts of a soothing / antiallergic agent. The humectant comprises at least two of ceramide NP, hydrolyzed sodium hyaluronate, and sodium hyaluronate. The soothing / antiallergic agent comprises a paeonia root extract. By designing the above ingredients and the proportion thereof, the formed synergistic active substance can achieve moisturizing and soothing effects mildly and efficiently, protect the skin barrier effectively, and keep the health of the skin with good safety.

The invention discloses a group of radix paeoniae rubra active ingredients which comprise paeoniflorin, chlorogenic acid and procyanidine, and also provides a group of root canal sealing medicine compounding agents which contain the radix paeoniae rubra active ingredients described in claim 1 and pharmaceutically acceptable carriers or auxiliary materials. The active component of the radix paeoniae rubra comprises one or a combination of more of paeoniflorin, chlorogenic acid and procyanidine. Compared with the prior art, the radix paeoniae rubra active ingredient, the root canal sealing medicine compound and the application have the advantages that the radix paeoniae rubra active ingredient and the root canal sealing medicine compound can be used for treating chronic periapical periodontitis based on the root canal sealing medicine.

The application provides a composition for soothing skin and removing red blood vessels, a preparation method, application and product, and relates to the technical field of cosmetics.The composition according to the application is composed of the following components in parts by weight: 50-200 parts of Vaccinium myrtillus leaf extract, 10-50 parts of palmitoyl tea extract, 2.5-5 parts of sphingomonad ferment extract, 32-64 parts of composite plant extract A and 0.12-1.2 parts of composite plant extract B; the composite plant extract A is cactus extract, radix ophiopogonis extract, oat bran extract, radix paeoniae extract and radix scrophulariae extract; the composite plant extract B is radix cnidii extract and radix notoginseng extract; the Vaccinium myrtillus leaf is subjected to microwave treatment, and then subjected to enzymatic extraction treatment with composite enzymes to obtain the Vaccinium myrtillus leaf extract. The composition has the effects of significantly removing red blood vessels and repairing sensitive skin, and can be applied to the preparation of cosmetics for soothing skin.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides anti-cold granules and a preparation method thereof. The preparation method comprises the following steps: (1) preparing an extract: performing ultrasonic water extraction on honeysuckle flower powder to obtain a honeysuckle flower extract; performing ultrasonic extraction on the radix paeoniae rubra powder by adopting a composite solvent to obtain a radix paeoniae rubra water extract; adding a natural clarifying agent into the red paeony root water extract for clarifying, cooling, filtering, and concentrating under reduced pressure to obtain a red paeony root extract; carrying out ultrasonic water extraction on rhizoma dryopteris crassirhizomae, filtering, and carrying out vacuum concentration to obtain a rhizoma dryopteris crassirhizomae extract; (2) mixing the honeysuckle extract, the radix paeoniae rubra extract and the rhizoma dryopteris crassirhizomae extract, and performing vacuum concentration to obtain clear paste; and adding auxiliary materials into the clear paste to prepare the anti-cold granules. By adopting the preparation method, the dissolution of effective components in the anti-cold granules can be remarkably improved, and particularly the contents of paeoniflorin and chlorogenic acid are increased, so that the liver toxicity generated by the medicinal component phloroglucinol derivative of the rhizoma dryopteris crassirhizomae is balanced, and the effects of reducing toxicity and enhancing efficiency are achieved.

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: Psoralea 6-18g, Herba Epimedii 6-20g, prepared Fufangpi 3-15g, Rhizoma Drynariae 6-20g, Radix Cyathulae 9-18g, Radix et Rhizoma Ampelopsis 12-24g, Radix et Rhizoma Clematis 6-12g, Herba Lysimachiae 10-30g, Radix et Rhizoma Smilacis glabrae 10-30g, Radix Paeoniae Rubra 9-15g, natural copper 6-12g, Geotrupes 3-9g, Radix et Rhizoma Ampelopsis 6-12g, Rhizoma Notopterygii 6-15g, Radix Angelicae Pubescentis 6-15g, Radix Angelicae Pubescentis 6-12g, Radix et Rhizoma Baphicacanthis 3-9g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicac

The invention relates to the technical field of cosmetics, in particular to a whitening, skin-tendering and anti-aging composition and a preparation method and application thereof.The whitening, skin-tendering and anti-aging composition is composed of the following components: a core active component: a peony root bark extract, the paeonol content of which is larger than or equal to 10% and the paeoniflorin content of which is larger than or equal to 8% (HPLC (High Performance Liquid Chromatography) detection); the solvent / carrier component is 1, 3-butanediol which is used as a compatible component of an extraction solvent and a cosmetic matrix; through efficient extraction with the 1, 3-butanediol and purification with a 5000Da ultrafiltration membrane, the content of paeonol is larger than or equal to 10%, the content of paeoniflorin is larger than or equal to 8%, and the content of paeonol and the content of paeoniflorin are obviously higher than those of commercially available peony extracts (generally paeonol is smaller than or equal to 5%), traditional ethyl alcohol is replaced with the 1, 3-butanediol, and therefore the paeoniflorin and paeoniflorin can be used for preparing the peony extract. The composition is low in irritation and good in compatibility with a cosmetic matrix, and is suitable for sensitive skin, and LD50 is greater than 2000mg / kg according to a skin irritation test.

The invention belongs to the technical field of acne rosacea treatment, and discloses a preparation method and application of a composition for treating acne rosacea, the composition for treating acne rosacea contains a moutan bark extract and a coptis chinensis extract, and also contains a lucid ganoderma extract, a cinnamon extract, paeoniflorin and syringic acid. The inflammatory response of rosacea is closely related to the expression of two core inflammatory factors, namely TNF-alpha and TLR4, and the invention consciously aims at the TLR4-TNF-alpha inflammatory axis multi-target design, inhibits the expression of TLR4 and TNF-alpha, and blocks the'start-amplification 'chain of inflammation, thereby inhibiting the recurrence of inflammation. In addition, the composition for treating rosacea provided by the invention can also improve capillary dysfunction, effectively inhibit microbial growth, and prevent and treat rosacea from multiple dimensions.

The application discloses a method for simultaneously controlling the qualitative and quantitative overall quality of a Huangqi Guizhi Wuwu Decoction (HGWD) reference sample, and the method is characterized in that: a water decoction process optimized through orthogonal tests is used to prepare HGWD decoctions and freeze-dried powder reference samples of multiple batches of medicinal material combinations from different producing areas; an HPLC characteristic chromatogram is established, 15 common peaks are calibrated by taking cinnamyl aldehyde as a reference peak; based on the same reference sample, the contents of eight index components, i.e., gallic acid, peony lactone glycoside, paeoniflorin, calycosin-7-glucoside, cinnamic acid, cinnamyl aldehyde, formononetin and 6-gingerol, are simultaneously determined by using a multi-wavelength HPLC, and the content of astragaloside A is determined by using an HPLC-ELSD method; the qualitative and quantitative overall quality of the reference sample is simultaneously controlled through characteristic chromatogram similarity evaluation and multi-index component content consistency evaluation. The application realizes the whole-process value transmission evaluation from medicinal material raw materials to final products, and provides a scientific basis for formulating the quality standard of the HGWD reference sample and developing granules.

The invention relates to the technical field of medicines, in particular to a pharmaceutical composition and application thereof in preparation of drugs for preventing or treating allergic asthma. The invention relates to a pharmaceutical composition which is definite in active ingredient, high in safety and capable of efficiently treating allergic asthma through a multi-target synergistic effect. The pharmaceutical composition comprises 8-O-debenzoyl paeoniflorin (8-DPF), pentagalloylglucose (PGG), paeoniflorin (PF) and white paeony root crude polysaccharide which serve as active ingredients. According to the composition, through scientific compatibility of the active ingredients of PGG, PF and 8-DPF and the radix paeoniae alba crude polysaccharide, triple effects of anti-inflammation, immunoregulation and bronchial relaxation are achieved, and the problems that an existing medicine is single in target spot, large in side effect, low in bioavailability and the like are solved.

The invention relates to the technical field of pharmacy, in particular to a detection method and application of Guanxinjing tablets. The detection method comprises the following steps: (1) identifying paeoniflorin in the Guanxinjing tablet by a thin layer chromatography, and (2) detecting the contents of tanshinol, protocatechualdehyde and salvianolic acid B in the Guanxinjing tablet by a high performance liquid chromatography, the method for detecting the content of each drug component in the monarch drug salvia miltiorrhiza in the Guanxinjing tablet and the method for detecting the drug components in the ministerial drug in the Guanxinjing tablet are not disclosed in the prior art, and a basis is provided for more accurate detection of the Guanxinjing tablet. The method for detecting paeoniflorin in radix paeoniae rubra through thin layer chromatography is good in specificity and durability. The high performance liquid chromatography for detecting the contents of tanshinol, protocatechuic aldehyde and salvianolic acid B in salvia miltiorrhiza is good in specificity, the recovery rate ranges from 95% to 105%, and the high performance liquid chromatography is good in accuracy, precision, linear relation and durability. And a basis is provided for strictly controlling the quality of the coronary heart calming tablet.

The invention discloses application of albiflorin in preparation of medicines for adjuvant therapy of cancers, and particularly relates to application of albiflorin in treatment of cancer-related fatigue and tumor-related depression. A chemotherapy-induced CRF blood deficiency and liver depression syndrome mouse model is adopted, the treatment effect of albiflorin on CRF and CRD is investigated through the tumor weight, the inhibition rate, behavioral indexes and peripheral hemogram, and the effect is better than that of a radix paeoniae alba water extract.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a preparation method and application of uremia clearing extract. The preparation method comprises the following steps: mixing rheum officinale, astragalus membranaceus, white mulberry root-bark, radix sophorae flavescentis, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, radix polygoni multiflori preparata, radix paeoniae alba, salvia miltiorrhiza, ligusticum wallichii, chrysanthemum, ginger processed pinellia, plantain herb, radix bupleuri and liquorice, and soaking in water to obtain a mixture; carrying out microwave extraction, filtering, collecting an extracting solution, and concentrating to obtain clear paste; and adding ethanol into the clear paste for alcohol precipitation, sequentially separating and purifying the supernatant through DM130 and LS-100 macroporous resins, collecting the eluent, and concentrating to obtain the traditional Chinese medicine composition. The preparation method of the uremia clearing extract is optimized, the extracting solution is obtained through microwave extraction, and then the specific purification process is adopted, so that the content of effective components such as paeoniflorin, astragaloside, stilbene glucoside and salvianolic acid B in the extract is obviously increased.

The present invention relates to a composition of paeoniflorin and isoliquiritigenin and application thereof. The composition according to the present invention is rich in raw materials, and has the effects of anti-inflammation, antioxidant, inhibiting collagen deposition, etc., and can be effectively used to treat diffuse interstitial pulmonary fibrosis with high economic and social benefits.

The invention relates to the technical field of skin care products, and particularly discloses a skin whitening agent composition. The skin whitening agent composition is prepared from the following components in parts by mass: 11.87 to 19.39 parts of a humectant; 4.95 to 10.75 parts of a whitening agent; 0.35 to 1.05 parts of a skin conditioning agent; 66.85 to 81.55 parts of a solvent; 1.28 to 1.96 parts of an auxiliary agent; the skin conditioner is prepared by compounding a poria cocos extract, a mulberry root bark extract, a Chinese herbaceous peony root extract, a chrysanthemum extract, a radix ampelopsis root extract, a bighead atractylodes rhizome root extract, a dictamnus dasycarpus root extract, a radix polygonati officinalis extract, a mangnolia officinalis bark extract, an angelica sinensis root extract and a rhizoma bletillae root extract; the whitening agent is prepared by compounding glabridin, nonapeptide-1, nicotinamide, azelamide MEA, tranexamic acid, glutathione, acetylchitosamine and papain. The whitening mask has the advantage of better whitening effect.

The invention relates to the technical field of biological medicines, and discloses a quality detection method of a composition for nourishing yin and clearing away lung-heat. The quality detection method comprises the following steps: identifying the radix scrophulariae, the radix paeoniae alba, the bulbus fritillariae cirrhosae, the menthol and the liquorice by adopting a thin layer chromatography; and determining the content of paeoniflorin in the composition by adopting a high performance liquid chromatography. According to the method provided by the invention, a thin-layer chromatography identification method for the five medicinal materials of radix scrophulariae, radix paeoniae alba, bulbus fritillariae cirrhosae, menthol and liquorice is systematically established for the first time, and high performance liquid chromatography content determination of the key active ingredient paeoniflorin is introduced, so that multi-component and multi-dimensional comprehensive evaluation of the product is realized. Each thin-layer identification method realizes clear spots, good separation degree, negative effect and no interference, and has strong specificity and reproducibility, the content determination method has good precision, stability and repeatability, the average adding standard recovery rate reaches 99.87%, the accuracy of a quantitative result is ensured, and the method is suitable for quality control in large-scale production.

The invention provides a paeoniflorin crystal form A and preparation method and application thereof. The crystal form A is characterized by means of XRD, IR, DSC, TGA and the like. The powder diffraction pattern of the crystal form A obtained by using an X-ray powder diffraction method of Cu Ka has diffraction peaks at the following angles of 2θ: 6.73°±0.2°, 7.94°±0.2°, 13.57°±0.2°, 15.53°±0.2°, 15.98°±0.2°, 17.16°±0.2°, 17.62°±0.2°, 20.45°±0.2°, 25.60°±0.2°. The paeoniflorin crystal form A of the present invention has low hygroscopicity and good physical stability, and is an ideal pharmaceutical crystal form.

The application discloses the application of Shaoyao Gancao Decoction in the preparation of a drug for treating chemotherapy-related diarrhea, and belongs to the technical field of medical applications. The application provides the application of Shaoyao Gancao Decoction in the preparation of a drug for treating chemotherapy-related diarrhea, wherein the chemotherapy-related diarrhea is intestinal toxicity diarrhea induced by a chemotherapy drug. Shaoyao Gancao Decoction is a water decoction extract, which is obtained by soaking, reflux extraction, filtration, concentration and drying of Radix Paeoniae Alba and Radix Glycyrrhizae in a weight ratio of 1:1. Shaoyao Gancao Decoction can improve diarrhea symptoms, reduce diarrhea index, reduce perianal pollution, restore intestinal flora diversity, and realize the treatment effect on chemotherapy-related diarrhea by regulating the AhR / NF-κB signal pathway.

The invention belongs to the field of pharmaceutical analysis, and particularly discloses a UPLC (Ultra Performance Liquid Chromatography) specific chromatogram detection method of immature bitter orange and Chinese herbaceous peony powder, which comprises the following steps: taking octadecylsilane chemically bonded silica as a filling agent for a chromatographic column; acetonitrile is used as a mobile phase A, and a 0.1-0.3% phosphoric acid solution is used as a mobile phase B; the gradient elution procedure lasts for 0-23 minutes, and 5%-47% A is obtained. The characteristic chromatogram established through specific chromatographic conditions can be used for calibrating characteristic components of different categories and different polarities including alkaloids, organic acids, flavones, flavonoid glycosides and the like. The calibration of the components realizes the quality control of the immature bitter orange and paeonia lactiflora powder, ensures the clinical curative effect of the immature bitter orange and paeonia lactiflora powder, and has practical popularization and application values.

The application provides a kind of pharmaceutical composition and its preparation method and application, it is related to medical technical field.The pharmaceutical composition of the application includes components: rehderin D, tortoise shell glue, berberine hydrochloride, beta-sitosterol, salt know mother, paeoniflorin and peony phenol;Wherein, radix rehmanniae preparata is mixed with methanol solution, heated extraction, extract liquid passes chromatographic column, finally eluted with methanol aqueous solution to obtain rehderin D;Take salt huang bai chop and mix with acid ethanol solution and soak, heated extraction is carried out ultrasonic treatment, filtrate is recovered ethanol under reduced pressure, to obtain berberine hydrochloride.The tortoise shell glue of the application is crushed to particle size 80-200 mesh, mixed with salt know mother extract and other components in the pharmaceutical composition, the obtained pharmaceutical composition can be applied to prepare menopausal syndrome drug, and / or treatment of nervous system disease drug, can significantly relieve menopausal syndrome symptoms, and has certain effect on the treatment of Parkinson, Alzheimer's disease.

The invention discloses a children qi depressing and asthma relieving mixture and a quality detection method thereof. The children qi depressing and asthma relieving mixture is prepared from honey-fried ephedra, scalded semen armeniacae amarae, fried fructus perillae, semen raphani, semen plantaginis, uncaria rhynchophylla, fried radix paeoniae alba and scutellaria baicalensis. According to the morbidity characteristics of the infantile asthma, the prepared infantile Qi-depressing asthma-relieving mixture can obviously relieve airway inflammation, improve lung functions and relieve airway hyperreaction, and has a good effect of treating the infantile asthma. According to the method, a detection method is screened through a large number of experiments, thin-layer chromatography qualitative identification and high performance liquid chromatography quantitative detection are adopted, ephedra sinica stapf, scalded semen armeniacae amarae, radix paeoniae alba and radix scutellariae are comprehensively and objectively detected and analyzed, and methodological investigation shows that the high performance liquid chromatography provided by the invention is high in precision and good in repeatability and stability. The traditional Chinese medicine composition has important significance for controlling the quality of the pediatric Qi depressing and calming asthma and ensuring the clinical curative effect.

A traditional Chinese medicine compound composition with anti-anxiety effect and its preparation method and application are disclosed. The traditional Chinese medicine compound composition with anti-anxiety effect is prepared by compounding the Paeoniae Radix Alba extract, the Gardeniae Fructus extract, the Albiziae Flos extract and the Moutan Cortex extract. The traditional Chinese medicine compound composition has no toxic side effects and has remarkable treatment effect, and can be used as a dietary supplement or a health-care food ingredient to prevent and treat anxiety disorder, and promote mental health. It can be seen that the traditional Chinese medicine compound composition is suitable for promotion and application.

The invention discloses a preparation method of paeoniflorin, and belongs to the technical field of natural pharmaceutical chemistry. The method comprises the following specific steps: firstly, extracting crude extracts from white peony root bark and doghead tablets, and then carrying out extraction, alcohol precipitation and silica gel column chromatography to obtain high-content paeoniflorin. The optimal extraction method is obtained by changing the proportion of the solvent for extraction, and it is found that the yield of paeoniflorin is up to 1.72% and the content of paeoniflorin is up to 95.62% when the white peony root bark and the doghead tablets are extracted with the solvent with the alcohol-water volume ratio of 7: 3. The method is simple in preparation step, mild in condition, high in extraction and separation efficiency and small in loss, the content of the obtained paeoniflorin is high, the radix paeoniae alba resource is fully utilized, and comprehensive utilization of the resource is achieved.

The invention relates to the technical field of raw materials of skin care products, and particularly discloses a preparation method of a paeonia lactiflora root extract, which comprises the following steps: step 1), putting paeonia lactiflora roots into an extracting solution, and heating and pressurizing for extraction to obtain an extract; step 2), filtering the extract, taking filtrate, and concentrating and drying the filtrate to obtain a Chinese herbaceous peony root extract rich in beta-pentagalloylglucose and oleanolic acid; the extracting solution is a compound of an ethanol water solution, acetic acid, acetone and chloroacetaldehyde. The method has the advantages that more beta-pentagalloylglucose and oleanolic acid are extracted from the paeonia lactiflora roots, so that the whitening and antioxidant effects of the paeonia lactiflora root extract are further improved.