6 results about "Evodiae Fructus" patented technology

The application discloses a model for evaluating microtoxicity of evodia extract based on fruit fly behavior and a construction method and application thereof, and belongs to the technical field of toxicity evaluation. In order to accurately, quickly and efficiently evaluate the microtoxicity of the evodia extract, avoid the fluctuation of the corresponding indexes of each behavior experiment of the fruit fly and better reflect the olfactory and gustatory behaviors of the fruit fly, the application successively connects a bidirectional selection feeding experiment, a Y type experiment and a proboscis extension experiment to construct a model for evaluating the microtoxicity of the evodia extract based on the fruit fly behavior, and the model has the characteristics of high accuracy, quickness and high efficiency and can be used for evaluating whether the evodia extract solution reaches a lethal concentration.

This invention belongs to the field of pharmaceutical application technology, specifically relating to an antifungal evodiamine derivative and its use in the preparation of antifungal substances. The structural formula of the evodiamine derivative is as follows: R1, R2, and R3 are independently H, halogen, or C1-3 alkyl groups; n1 is 1-3; the group is located at the 1, 3, or 4 position of the benzene ring; R4, R5, and R6 are independently C1-3 alkyl groups. The evodiamine derivative has an antifungal effect, especially against Trichophyton rubrum or Trichophyton mentagrophytes, expanding the selection range of antifungal drugs, reducing the possibility of drug-resistant strains, and improving the inhibitory effect on drug-resistant bacteria.

The application relates to the technical field of compound medicines, and discloses application of a compound external-use patch for preventing and treating diabetic peripheral neuropathy, wherein the compound external-use patch comprises a gel base and dry extract and volatile oil doped into the gel base, the dry extract and the volatile oil are derived from a compound, and the compound is composed of 10-20 parts of cinnamon, 8-12 parts of asarum, 8-12 parts of evodia, 8-12 parts of chuanxiong and 0.2-0.8 parts of borneol in terms of weight parts. The compound external-use patch of the application is locally pasted on acupoints or joints of DPN rats, can reduce the blood sugar level of diabetic peripheral neuropathy rats, increase the insulin level, improve insulin resistance, prolong the latent period of hot stimulation foot withdrawal, increase the nerve conduction velocity, maintain the normal morphology and function of nerve cells, and therefore can prevent and inhibit the generation and deterioration of diabetic peripheral neuropathy; and the compound external-use patch improves the safety and convenience of patients in taking medicine compared with oral medicine.

The application relates to the technical field of medicines, and provides a preparation method of a new amide alkaloid compound, i.e., wuzhuyu amide B (1-methyl-3-(2-(quinazolin-4-yl)ethyl)quinazoline-2,4(1 H ,3 H )‑dione) with tumor disease treatment and the use in the medical field for treating cancer, which can be used in the medical field.

The application discloses a traditional Chinese medicine composition for assisting tumor patients in warming yang, removing blood stasis and relieving pain and a hot compress bag thereof, and relates to the technical field of externally used hot compress traditional Chinese medicine.The traditional Chinese medicine composition comprises the following raw materials: prepared aconite, dried ginger, evodia, Sichuan pepper, cumin, astragalus, angelica, cassia, fried raphanus and fried licorice.This traditional Chinese medicine composition takes the thought of supporting yang as the core, follows the prescription logic of'supporting yang to consolidate the foundation and removing evil without damaging the healthy qi', precisely matches the physical characteristics of tumor patients 'deficiency of healthy qi as the root and evil toxin and blood stasis as the branch', and through the compatibility of medicinal materials for warming and supporting the congenital kidney yang, warming and dredging the meridian blood stasis and tonifying qi and nourishing blood to support the healthy qi, the core pathogenesis of 'yang deficiency-cold coagulation-toxin and blood stasis' of cancer patients is directly attacked, the yang deficiency constitution is regulated, the double goals of symptom relief and constitution improvement are realized, the pathological vicious circle is prevented, the regulation is more fundamental, and the limitation of only relieving the superficial symptoms without treating the root is avoided.

The application provides a selenium-rich traditional Chinese medicine composition, an oral liquid and application in prevention of alcoholic acute gastric mucosal injury. The selenium-rich traditional Chinese medicine composition comprises, in mass parts, 25-40 parts of a selenium-treated traditional Chinese medicine, 5-10 parts of cuttlefish bone, 5-10 parts of saussurea costus, 5-10 parts of fructus aurantii, 5-8 parts of modified coptis, 5-10 parts of evodia, 10-15 parts of bletilla striata, 5-10 parts of salvia miltiorrhiza, 10-20 parts of flos paeoniae, 10-20 parts of radix puerariae, 5-15 parts of amomum kravanh, 5-15 parts of litsea cubeba, 10-20 parts of hovenia dulcis thunb, and 10-20 parts of schisandra chinensis. The synergistic design of the selenium-rich traditional Chinese medicine composition achieves preventive protection on alcoholic acute gastric mucosal injury, and provides a new selection for prevention and treatment of alcohol-related gastric mucosal injury.