151 results about "Evodiae Fructus" patented technology

The invention discloses a traditional Chinese medicine compound and preparation for reducing blood uric acid and relieving pain and a preparation method of the traditional Chinese medicine compound, belongs to the technical field of traditional Chinese medicine compounds, and solves the technical problem that at present, a medicine which does not have side effects and is used for treating hyperuricemia is lacked. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-30 parts of cortex phellodendri, 5-20 parts of rhizoma coptidis, 15-30 parts of rhizoma atractylodis, 20-40 parts of semen coicis, 10-30 parts of radix cyathulae, 10-30 parts of pawpaw, 3-5 parts of fried fructus evodiae, 15-50 parts of radix astragali, 5-15 parts of The traditional Chinese medicine composition has the effects of reducing blood uric acid, resisting inflammation and relieving pain, is reasonable in compatibility, complements each other and has a synergistic effect, and the effects of reducing blood uric acid, resisting inflammation and relieving pain are increased.

The invention discloses a traditional Chinese medicine composition for treating constipation and a preparation method thereof, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20g of radix aconiti lateralis preparata, 5-15g of fructus evodiae, 20-30g of herba epimedii, 35-45g of radix astragali, 10-20g of ginseng, 5-15g of rhizoma atractylodis macrocephalae, 20-35g of semen coicis, 50-60g of fructus aurantii immaturus, 10-20g of betel nut and 5-15g of honey-fried licorice root. Comprising the following steps: (1) accurately weighing the raw materials in parts by weight, respectively pulverizing, sieving with a 200-mesh sieve, and mixing to obtain mixed medicinal powder for later use; and 2) adding the mixed medicine powder into a full-automatic traditional Chinese medicine watered pill machine, adding cooked millet accounting for 1-5% of the total amount of the mixed medicine powder, starting the full-automatic traditional Chinese medicine watered pill machine, and processing to obtain watered pills.

The invention discloses a method for detecting and identifying a traditional Chinese medicine evodia base based on electronic nose smell, and belongs to the technical field of traditional Chinese medicinal materials and quality analysis and detection. To-be-detected powder is injected through a headspace sample injection bottle and detected through an electronic nose, a sensor response value is obtained, W1S serves as a differential sensor, W6S serves as a reference sensor, and the basis of the traditional Chinese medicine fructus evodiae is determined according to the ratio of the W1S response value to the W6S response value; when the response value ratio of the W1S to the W6S is 2.4-3.1, the product is evodia rutaecarpa, when the response value ratio of the W1S to the W6S is 3.5-5.2, the product is botrytis chinensis, and when the response value ratio of the W1S to the W6S is 5.8-6.5, the product is evodia rutaecarpa. The method for detecting and identifying the traditional Chinese medicine evodia base on the basis of the electronic nose smell, provided by the invention, has the advantages of rapidness, no damage, no need of complex sample pretreatment, simplicity, environmental protection, low detection cost and visual result, and is suitable for rapidly, objectively and accurately judging the traditional Chinese medicine evodia base in batches.

The invention belongs to the technical field of cosmetics, and particularly discloses a natural anti-saccharification composition with plant extracts as main components, application, emulsion and a preparation method. The natural anti-saccharification composition with the plant extracts as the main raw materials comprises walnut seed extracts, sea-buckthorn extracts, aesculus hippocastanum extracts, fructus evodiae extracts, ormosia henryi bark extracts and capryloyl hydroximic acid. According to the formula system, multi-stage intervention in the whole saccharification reaction process is achieved through the multi-target-point and multi-channel synergistic effect, the comprehensive effects of aging resistance and tissue function protection are achieved, meanwhile, all the components have the synergistic effect in the aspects of oxidation resistance, saccharification resistance and repairing, abnormal combination of carbohydrates and protein / lipid is inhibited or hindered, and the anti-aging and anti-saccharification effects are achieved. According to the composition, the whole saccharification reaction process is inhibited, the effect stronger than that of a single component can be achieved, then generation of end-of-saccharification products is delayed, and the anti-aging capacity of skin is improved.

The invention discloses a traditional Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis, relates to the technical field of traditional Chinese medicines, and particularly aims to solve the problem of relatively narrow application prospects of treatment means applied to GERD at present in the background technology. Comprising rhizoma bletillae, calcined concha arcae, rhizoma pinelliae preparata, caulis bambusae in taeniam, fructus aurantii immaturus, pericarpium citri reticulatae, liquorice, poria cocos, coptis chinensis, fructus evodiae, platycodon grandiflorum and radix curcumae, and the traditional Chinese medicine composition is superior to western medicines, effective in treatment of the gastroesophageal reflux disease, small in side effect and economical and practical.

The invention relates to a traditional Chinese medicine preparation for treating mild and moderate spleen and kidney deficiency and phlegm and blood stasis type Alzheimer's disease sleep disorder and a preparation method of the traditional Chinese medicine preparation, and belongs to the field of traditional Chinese medicine treatment preparations for Alzheimer's disease. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials: rhizoma acori graminei, borneol, poria with hostwood, rhizoma atractylodis macrocephalae, codonopsis pilosula, radix astragali preparata, fructus evodiae, ramulus euonymi, polygala tenuifolia, lily, caulis polygoni multiflori and fossil fragments. The traditional Chinese medicine composition is used for treating mild and moderate spleen and kidney deficiency and phlegm and blood stasis type Alzheimer's disease sleep disorder, and has a good treatment effect. Sleep of patients with mild and moderate spleen and kidney deficiency and phlegm and blood stasis type Alzheimer's disease sleep disorder is evaluated through the intelligent bracelet, sleep condition quantitative monitoring is conducted, traditional Chinese medicine acupoint application treatment is conducted through a traditional Chinese medicine characteristic therapy method, the sleep quality and structure changes of the patients are evaluated, the treatment effect of traditional Chinese medicine acupoint application on the patients is researched, and the clinical application prospect is wide. Therefore, a clinical basis is provided for objective evaluation and standardized treatment of the sleep disorder, and the method has very important clinical significance for improving the life quality of a patient and evaluating prognosis.

The present invention discloses a class of rutaecarpine derivatives or their pharmaceutically acceptable salts with multi-target anti-tumor activity, and the general structural formula is shown as Formula I or Formula II: #imgabs0# Wherein: R1 is selected from C1-C5 alkoxy, hydroxyl, hydrogen; R2 is selected from hydrogen, halogen; R3 is selected from hydroxyl, #imgabs1# Through enzyme inhibition activity and in vitro anti-tumor activity tests, it was found that the compounds of the present invention have strong inhibitory activities against topoisomerase 1, topoisomerase 2 and c-MYC oncogene, opening up a new way and providing a new strategy for in-depth research and development of anti-tumor drugs with new structural types.

The invention belongs to the technical field of food nutrition and health, and particularly discloses protein powder for assisting in improving Alzheimer's disease and a preparation method of the protein powder according to the concept of dietary therapy in China, and the protein powder is prepared from the following components in percentage by weight: 35-45% of egg white protein peptide powder and 55-65% of core function compound powder. According to the invention, egg white protein peptide is used as a high-quality matrix, and nine specific medicinal materials including hippocampus, egg yolk phospholipid, egg membrane peptide, walnut, fructus alpiniae oxyphyllae, gastrodia elata, mulberry, sargassum fusiforme, wolfberry, ginkgo leaf, fructus evodiae and dandelion are cooperatively compatible; aiming at seven core pathological links of Alzheimer's disease, such as A beta deposition, Tauopathy, neuroinflammation, oxidative stress, cholinergic deficiency, neurodystrophy and cerebral circulation disorder, a multi-target synergistic effect network is constructed, comprehensive neuroprotection is realized, and tests prove that the space learning and memory ability and the autonomous activity ability can be effectively improved.

The application discloses a point application traditional Chinese medicine composition with an effect of treating irritable bowel syndrome, a point application plaster and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The application provides a point application traditional Chinese medicine composition and a point application plaster. The traditional Chinese medicine composition comprises the following components: psoralea, radix codonopsis, dried zedoary, fried atractylodes, mace, schisandra chinensis and evodia. The composition is prepared according to the principle of less medicine and special function and treatment of disease and seeking the origin. The core tonifying medicine, psoralea, dried zedoary and radix codonopsis, has a prominent dosage proportion and remarkable effects of warming the spleen and kidney yang and invigorating the spleen and replenishing qi. The application finds through clinical research that the clinical total effective rate of the test group is 76.7%, the curative effect is accurate and better than that of a placebo, the IBS-SSS score, the TCM syndrome score and the stool character score of IBS patients can be reduced, the symptoms of the patients are improved, and the composition can effectively treat IBS.

The invention relates to a traditional Chinese medicine composition and patch for treating tourette syndrome of children, and belongs to the technical field of traditional Chinese medicine compositions.The traditional Chinese medicine composition is prepared from calcined oyster shell, semen boitae, radix bupleuri, rhizoma gastrodiae, radix paeoniae alba, rhizoma curcumae longae, periostracum cicada, honey-fried licorice root, rhizoma zingiberis, szechwan chinaberry fruit, rhizoma coptidis, fructus evodiae, uncaria and the like. The preparation method of the patch provided by the invention comprises the following steps: mixing radix bupleuri, uncaria rhynchophylla and the like, and performing alcohol extraction to obtain an alcohol extraction extract; performing water extraction on platycladi seeds, gastrodia elata and the like to obtain water extract; mixing the calcined oyster shell powder, the alcohol extract, the water extract and the hydrogel matrix to obtain a medicine carrying layer; the medicine carrying layer and the permeation enhancing layer are attached, and the patch is obtained after plastic packaging. The composition disclosed by the invention is reasonable in compatibility, has a good treatment effect on the tourette syndrome of children, and is stable in curative effect and good in transdermal absorption efficiency.

The invention provides herbal ointment for relieving limpness, numbness and swelling pain and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from the following raw materials: codonopsis pilosula, cinnamon, angelica sinensis, corydalis serrate, paeonia lactiflora, peony root bark, ligusticum chuanxiong hort, liquorice, fructus evodiae, caulis spatholobi, leonurus, rhizoma corydalis, garden balsam stem, radix aconiti carmichaeli, rhizoma atractylodis, lycopodium clavatum, cortex dictamni, ramulus mori, radix clematidis, rhizoma arisaematis, semen brassicae and notopterygium root. The herbal ointment for relieving limp, numb and swelling pain has the effects of promoting blood circulation to remove blood stasis, expelling wind and removing cold, relieving pain and clearing damp, expelling toxin and enhancing immunity, is good in transdermal absorption promoting effect, long in contact time with skin and lasting in acting effect, can well improve toothache and arthralgia caused by shoulder pain, cervical vertebra pain, waist soreness and back pain, stiff neck, dizziness, headache and excessive internal heat, and has the effects of relieving pain, relieving swelling pain, relieving pain and relieving swelling pain. , varicosity, sprain, bruise, limpness, numbness and swelling pain of limbs, and the like, and has a wide application prospect.

The invention discloses a composition, a medicine containing the composition, a combined medicine and application. The composition comprises fructus evodiae or other qi promoting components, a blood stasis dispersing component, a middle-jiao warming, cold dispelling and spleen tonifying component, liquorice, a blood generating and activating component, a wind-cold dispersing component and a kidney reinforcing component. The composition disclosed by the invention has a good antiviral effect, and can assist qi and blood generation so as to transform cold-dampness, so that antiviral effect is realized, and meanwhile, the body function is improved.

The invention discloses a traditional Chinese medicine compound for preventing or treating digestive tract mucositis caused by targeted drugs, which is prepared from the following components in parts by weight: 2-4 parts of fructus evodiae, 5-7 parts of marmor serpentinatum, 5-7 parts of geranium wilfordii, 5-7 parts of persimmon frost and 2-4 parts of rhizoma kaempferiae, preferably 3: 6: 6: 6: 3. The preparation method is water decoction and concentration. The compound has the effects of eliminating cold to stop pain, supporting yang to stop diarrhea, dispersing blood stasis, stopping bleeding and the like, obviously reduces the index of diarrhea caused by TKI and the score of oral mucositis, and is suitable for complication management of targeted therapy of NSCLC patients in the stage IV. An orthogonal test verifies scientificity of the formula, and the formula has safety and effectiveness.

The invention relates to a traditional Chinese veterinary medicine preparation for treating piglet diarrhea as well as a preparation method and application of the traditional Chinese veterinary medicine preparation. The traditional Chinese medicine composition is prepared from the following raw materials and auxiliary materials, wherein the raw materials comprise poria cocos, humifuse euphorbia herb, catechu, smoked plum, scorched hawthorn fruit, radix paeoniae alba, liquorice, fructus evodiae, radix aucklandiae, rhizoma atractylodis macrocephalae and hawthorn fruit; the auxiliary materials comprise a disintegrating agent modified starch, a filling agent dextrin, a flavoring agent sucrose and steviosin; the mass ratio of the raw materials to the auxiliary materials is 1: (1-3), starch, mannitol, dilauroyl peroxide and a solvent DMSO react to obtain cross-linked starch, and then the cross-linked starch, water, anhydrous sodium sulfate, sodium chloride, acetic anhydride and a sodium hydroxide solution react to obtain the modified starch. According to the present invention, the piglet diarrhea can be effectively treated, the drinking water administration mode is adopted, the advantages of accurate metering, rapid effect, convenient administration and the like are provided, the clinical medication safety on piglets is high, the growth performance of piglets is not affected, and the method is suitable for mass production and large-scale use.

The present invention belongs to the field of feed additives, and specifically relates to a Chinese medicine composition having the function of improving the intestinal health of rabbits, and a preparation method and application thereof. The present invention provides a Chinese medicine formula for improving the intestinal health of rabbits, comprising 2-5 parts of astragalus; 1-3 parts of evodia rutaecarpa; 1-3 parts of dried orange peel; and 1-3 parts of liquorice. The Chinese medicine composition and feed provided by the present invention can improve the growth performance of rabbits, regulate fat metabolism and energy metabolism, improve the body's immunity, enhance the digestive capacity and antioxidant capacity of the intestines, and improve the intestinal morphology.

The invention belongs to the field of microneedle transdermal drug delivery, and particularly relates to an acupoint drug delivery soluble evodia rutaecarpa microneedle as well as a preparation method and application thereof in treatment of oral ulcer. The preparation method comprises the following steps: modifying effective biological components in fructus evodiae to obtain a solid dispersion, and then mixing the solid dispersion with a needle tip matrix to prepare the drug-loaded microneedle. Wherein the effective biological component in the fructus evodiae is evodiamine (EVO) or rutaecarpin (RUT). The medicinal evodia soluble drug-loaded microneedle is prepared, and the medicinal evodia soluble drug-loaded microneedle is attached to the pelma Yongquan acupoint to treat oral ulcer through matching of the medicinal evodia and the acupoint.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following raw materials: fructus evodiae, salted fennel, combined spicebush root, piper cubeba, radix aconiti lateralis preparata, cassia twig, clove, vinegar frankincense, vinegar myrrh and angelica sinensis. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 10 parts of fructus evodiae, 15 parts of salted fennel, 10 parts of radix linderae, 10 parts of piper cubeba, 30 parts of radix aconiti lateralis preparata, 10 parts of cassia twig, 10 parts of clove, 10 parts of vinegar frankincense, 10 parts of vinegar myrrh and 10 parts of angelica sinensis. The traditional Chinese medicine composition disclosed by the invention is combined with the syndrome of congealing cold with blood stasis, utilizes the treatment method of mainly warming and dredging and also activating and nourishing blood, is synergistic in all the medicines and tightly focuses on the mechanism of congealing cold with blood stasis, so that cold evil is dissipated, qi and blood are warm, stasis is promoted, qi and blood of Chong and Ren channels are harmonized, menstrual blood flows smoothly, and pains are stopped.

The application discloses a traditional Chinese medicine composition for treating pancreatic cancer, which comprises the following medicinal materials in parts by weight: 1-20 parts of Chinese cork tree, 1-15 parts of ginkgo, 1-10 parts of evodia, 1-10 parts of tripterygium, 1-15 parts of two-edged needle, 1-15 parts of radix astragali, and 1-10 parts of jujube. The application further discloses a medicine taking the traditional Chinese medicine composition as raw materials and a preparation method of the medicine. In addition, the application further discloses application of the traditional Chinese medicine composition or the medicine in preparation of a medicine for treating pancreatic cancer.

The invention discloses a method for preparing evodiamine, comprising the following steps: S1, performing a mitsunobu reaction on a tryptamine alcohol, dialkyl azodicarboxylate, triphenylphosphine and diphenylphosphoryl azide in a first reaction solvent to prepare a tryptamine alkyl azide derivative intermediate; S2, performing an intermolecular Mukaiyama-Michael addition reaction on the tryptamine alkyl azide derivative intermediate obtained in step S1 and N-methyl-3-OTMS indole in a second reaction solvent through Lewis acid catalysis, and obtaining evodiamine by an intramolecular Boyer-Schmidt-Aube rearrangement one-pot method. The invention provides a new process and new ideas for synthesizing evodiamine, and the process route of the invention is simple and not redundant, and the reaction yield is high, which has great innovation, enriches the synthesis method of evodiamine, and has good potential for large-scale industrial production.

The invention provides a traditional Chinese medicine preparation for treating gastrointestinal diseases, and relates to the technical field of traditional Chinese medicine, and the traditional Chinese medicine preparation for treating gastrointestinal diseases comprises the following components in parts by weight: 6-10 parts of cuttle bone, 1-2 parts of thunberg fritillary bulb, 4-6 parts of bletilla striata, 2-4 parts of pericarpium citri reticulatae, 5-8 parts of calcined corrugated seed, 2-4 parts of pseudo-ginseng, 1-3 parts of combined spicebush root, 2-4 parts of corydalis tuber, 2-4 parts of microcos paniculata, 2-4 parts of fried madder and 2-4 parts of coptis chinensis. The traditional Chinese medicine composition is prepared from 2-4 parts of fructus mume, 0.5-2 parts of cortex cinnamomi, 1-4 parts of radix salviae miltiorrhizae, 1-4 parts of radix angelicae sinensis, 1-4 parts of radix paeoniae alba, 0.5-2 parts of fructus evodiae, 2-4 parts of crinis trachycarpi, 2-4 parts of herba agrimoniae, 1-4 parts of fried pollen typhae and 1-4 parts of carbonized sanguisorba root. According to the method for treating gastrointestinal diseases provided by the invention, a plurality of Chinese herbal medicines including cuttle bone, thunberg fritillary bulb, bletilla striata, dried orange peel, calcined corrugated seed, pseudo-ginseng and combined spicebush root are used as basis, and are accurately proportioned and processed according to respective medicinal characteristics and medicinal effects; and a unique formula for soothing liver and strengthening spleen, regulating cold and heat, astringing to stop bleeding, diminishing swelling and promoting tissue regeneration, relieving hyperacidity and pain, and protecting and repairing gastrointestinal mucosa is formed.

A 2,3-fused quinazolinone derivative, its preparation method, and application are disclosed. A 2,3-quinazolinone derivative was synthesized using a simple method with high yield and low production cost. At a concentration of 5 µM and an LPS concentration of 1 µg / mL, compounds 1e and 1f exhibited superior NO release inhibition compared to the anti-inflammatory drugs indomethacin and evodiamine, while compounds 1g and 1q were comparable to indomethacin, and compounds 1w and 1m were comparable to evodiamine. Compounds 1e, 1f, 1g, 1q, and 1m, which exhibited strong NO release inhibition, exhibited less cytotoxicity against RAW264.7 cells than the anti-inflammatory drugs indomethacin and evodiamine. The derivative exhibited significant anti-inflammatory effects and low toxicity. The derivative can be formulated into various dosage forms of anti-inflammatory drugs, possessing high medical value and broad market prospects.

The invention discloses a ginseng lactic acid bacteria fermented beverage and a preparation method thereof, and belongs to the technical field of lactic acid bacteria, the ginseng lactic acid bacteria fermented beverage comprises the following raw materials in parts by weight: 400-600 parts of ginseng, 400-600 parts of grapes and 40-60 parts of auxiliary materials, the production place of the ginseng is set as Changbai Mountain, the production place of the grapes is set as Xinjiang, and the production place of the grapes is set as Xinjiang. The auxiliary material is a composition of chrysanthemum, hawthorn, loquat, kudzuvine root, mountain jujube, pitaya, kumquat, rhizoma polygonati, cordyceps militaris, sea-buckthorn, Chinese date, mulberry, dandelion, cassia seed, gordon euryale seed, kumquat, sugarcane, dendrobe, fructus evodiae, lucid ganoderma and cistanche. The preparation method of the ginseng lactobacillus fermented beverage comprises the following steps: step 1, crushing: crushing grapes, and then introducing the crushed grapes into a fermentation tank; according to the ginseng lactobacillus fermented beverage and the preparation method thereof, the ginseng lactobacillus fermented beverage is rich in taste and beneficial to human bodies.

The invention belongs to the technical field of traditional Chinese medicine navel patches, and particularly relates to a composite medicine carrying navel therapy patch based on a PU film and a preparation method thereof.The composite medicine carrying navel therapy patch comprises an anti-sticking release film, a medicine carrying layer, a medical pressure-sensitive adhesive layer and a PU waterproof protective layer; the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10 to 20 parts of rhizoma zingiberis, 10 to 15 parts of roasted rhizoma atractylodis macrocephalae, 8 to 12 parts of radix codonopsis, 5 to 10 parts of fructus evodiae, 5 to 10 parts of fructus foeniculi, 3 to 8 parts of cortex cinnamomi, 1 to 3 parts of borneol, 8 to 20 parts of polysorbate 80, 0.5 to 2 parts of carbomer 940, 1 to 3 parts of triethanolamine and 0.1 to 0.5 part of EDTA-2Na. By means of the integrated design of slow-release hydrogel drug loading and the multi-layer patch, efficient transdermal absorption and stable release of drugs are achieved, and the bioavailability and application comfort of the composite drug-loading navel therapy patch are improved.

The invention belongs to the technical field of du-moxibustion, and particularly relates to a'five-color soil 'traditional Chinese medicine composition for du-moxibustion. The traditional Chinese medicine composition is prepared from a cyan composition, a red composition, a yellow composition, a white composition and a black composition according to the mass ratio of 1: 1: 1: 1: 1. The cyan composition consists of ligusticum wallichii, kadsura pepper stem, fructus evodiae, pericarpium citri reticulatae viride and indigo naturalis; the red composition is prepared from caulis spatholobi, radix salviae miltiorrhizae, caulis sargentodoxae, radix paeoniae rubra and flos carthami; the yellow composition is prepared from rhizoma atractylodis, rhizoma smilacis glabrae, radix angelicae sinensis, rhizoma corydalis and rhizoma curcumae longae; the white composition is prepared from radix angelicae, cortex moutan, radix puerariae, fructus amomi rotundus and radix aconiti carmichaeli; the black composition consists of radix angelicae pubescentis, notopterygium root, radix aconiti, asarum, clove and moxa charcoal; a'five-color soil 'traditional Chinese medicine composition is used in a traditional du-moxibustion therapy in an overlapping manner, so that the effects of external treatment, ironing and du-moxibustion of traditional Chinese medicines are synchronously exerted, acupuncture points are well stimulated, meridian circulation of governor meridians and bladder meridians is promoted and stimulated, and the ideal effects of comprehensively improving yang qi of a human body and conditioning viscera are achieved.

The invention discloses a traditional Chinese medicine hot compress bag for nursing in the perioperative period. The traditional Chinese medicine hot compress bag comprises the following traditional Chinese medicine components by weight: 120-180g of fructus evodiae, 120-180g of semen raphani, 120-180g of fructus aurantii, 120-180g of cortex magnoliae officinalis and 120-180g of fructus foeniculi. By using the traditional Chinese medicine hot compress bag for perioperative nursing, postoperative hypothermia under general anesthesia can be effectively prevented and treated, the occurrence rate of postoperative shivering is reduced, postoperative pain is relieved, the postoperative comfort of a patient is improved, and postoperative recovery of the patient is promoted.

The invention relates to a traditional Chinese medicine preparation for treating gastroenteritis and a preparation method and application thereof. The traditional Chinese medicine preparation for treating gastroenteritis comprises the following raw materials: codonopsis pilosula, bighead atractylodes rhizome, poria cocos, pericarpium citri reticulatae, pinellia ternate, fructus evodiae, coptis chinensis, fructus aurantii, salvia miltiorrhiza, lignum dalbergiae odoriferae, fructus amomi, raw malt, raw rice sprout, rhizoma sparganii, curcuma zedoary and cinnamon. The invention further discloses a preparation method and application of the traditional Chinese medicine preparation for treating gastroenteritis. The traditional Chinese medicine composition for treating gastroenteritis is simple to prepare, good in absorption effect, remarkable in curative effect, free of side effects, high in safety and beneficial to relieving the symptoms of gastroenteritis.

The invention relates to the technical field of medicinal chemistry and pharmacotherapeutics, in particular to a technology and a method for confirming toxic targets of evodiamine (EVO) and accurately evaluating hepatotoxicity of evodiamine. The method comprises the following steps: determining that EVO can be directly combined through biotin labeling, pulldown, mass spectrum combination, small molecule transfection and the like, and up-regulating liver zo-1 protein to cause liver injury, while up-regulating the intestinal tract target is a key mechanism for treating the inflammatory bowel disease by EVO. By comparing the protein levels in the liver-intestine axes of animals in different states, the fact that the down-regulation of the ZO-1 protein level in the liver-intestine axis under the inflammatory bowel disease state can partially antagonize the EVO to the up-regulation of the liver ZO-1 is found, so that the liver toxicity is reduced, and only the therapeutic activity of the EVO is retained. The discovery provides an accurate target spot for understanding an EVO toxicity mechanism, and is beneficial to realizing accurate regulation and control in drug research and development and toxicity prevention in the future; meanwhile, the drug effects and toxic mechanisms of EVO in organisms in different states are compared from the aspect of ZO-1 protein expression in the liver-intestine axis, and direct evidence is provided for the theory of combating poison with poison in toxic traditional Chinese medicine.

The invention discloses a traditional Chinese medicine composition for assisting a tumor patient in warming yang, removing stasis and easing pain and a hot compress bag thereof, and relates to the technical field of external hot compress traditional Chinese medicines, the traditional Chinese medicine composition comprises the following raw materials: radix aconiti lateralis preparata, rhizoma zingiberis, fructus evodiae, pericarpium zanthoxyli, fennel, astragalus membranaceus, angelica sinensis, cinnamon, fried semen raphani and honey-fried licorice root. The traditional Chinese medicine formula takes the idea of strengthening yang as the core, follows the formula logic of strengthening yang to strengthen the root and eliminating evil without hurting healthy qi, accurately accords with the physical characteristics of'deficiency of healthy qi and stasis of evil toxin 'of tumor patients, directly strikes the core pathogenesis of'deficiency of yang-congealing cold-stasis toxin' of cancer patients through the compatibility of medicinal materials for warming and strengthening congenital kidney yang, warming and dredging meridian stasis, tonifying qi, nourishing blood and strengthening body resistance, and has a remarkable curative effect. The traditional Chinese medicine composition is capable of conditioning yang-deficiency constitution, realizing dual goals of relieving symptoms and improving constitution, preventing pathological vicious circle, enabling conditioning to be more fundamental, and avoiding the limitation that only surface symptoms are relieved and are not treated fundamentally.

The invention discloses an anti-enterocytozoon hepatopenaei traditional Chinese medicine compound and a preparation method and application thereof.The anti-enterocytozoon hepatopenaei traditional Chinese medicine compound is characterized by being prepared from, by weight, 10-20 parts of sophora alopecuroide alcohol extract, 50-75 parts of cortex fraxini alcohol extract and 10-30 parts of fructus evodiae alcohol extract.The preparation method comprises the following steps that dried and smashed sophora alopecuroide, cortex fraxini and fructus evodiae are weighed; respectively dissolving and extracting by using absolute ethyl alcohol to obtain alcohol extracts; the preparation method comprises the following steps: weighing the traditional Chinese medicine alcohol extract in parts by weight, uniformly mixing to obtain the anti-enterocytozoon hepatopenaei traditional Chinese medicine compound, and further provides application of the anti-enterocytozoon hepatopenaei traditional Chinese medicine compound, the sophora alopecuroide alcohol extract, the ash bark alcohol extract and the fructus evodiae alcohol extract in preparation of an enterocytozoon hepatopenaei inhibitor. The weight gain rate of prawns is increased, economic losses caused by outbreak of enterocytozoon hepatopenaei to prawn culture can be effectively reduced, and the compound is low in cost and simple in use method.

The invention belongs to the field of traditional Chinese medicines, and particularly discloses modified fructus evodiae soup as well as a preparation method, application and a pharmaceutical composition thereof. The decoction is prepared from a plurality of traditional Chinese medicinal materials such as fructus evodiae, fried codonopsis pilosula, Chinese dates, dried ginger and the like according to a specific proportion, and is mainly used for treating Jueyin headache or headache caused by cerebral ischemia injury. The preparation method comprises the following steps: soaking the medicinal materials, decocting, filtering, combining and the like, and selectively adding the steps of concentrating, packaging and storing. In addition, the invention further provides a pharmaceutical composition containing the modified fructus evodiae decoction and the ibuprofen for treating headache, the pharmaceutical composition aims at achieving the synergistic effect of medicines in a mode of combining traditional Chinese medicine and western medicine, reducing the dosage of the western medicine, reducing side effects and improving the curative effect, and the content of the modified fructus evodiae decoction and the content of the ibuprofen in the composition are both in a clear range. Therefore, the treatment effect and the safety are ensured.