57 results about "Evodiae Fructus" patented technology

The invention belongs to the technical field of cosmetics, and particularly discloses a natural anti-saccharification composition with plant extracts as main components, application, emulsion and a preparation method. The natural anti-saccharification composition with the plant extracts as the main raw materials comprises walnut seed extracts, sea-buckthorn extracts, aesculus hippocastanum extracts, fructus evodiae extracts, ormosia henryi bark extracts and capryloyl hydroximic acid. According to the formula system, multi-stage intervention in the whole saccharification reaction process is achieved through the multi-target-point and multi-channel synergistic effect, the comprehensive effects of aging resistance and tissue function protection are achieved, meanwhile, all the components have the synergistic effect in the aspects of oxidation resistance, saccharification resistance and repairing, abnormal combination of carbohydrates and protein / lipid is inhibited or hindered, and the anti-aging and anti-saccharification effects are achieved. According to the composition, the whole saccharification reaction process is inhibited, the effect stronger than that of a single component can be achieved, then generation of end-of-saccharification products is delayed, and the anti-aging capacity of skin is improved.

The invention belongs to the technical field of food nutrition and health, and particularly discloses protein powder for assisting in improving Alzheimer's disease and a preparation method of the protein powder according to the concept of dietary therapy in China, and the protein powder is prepared from the following components in percentage by weight: 35-45% of egg white protein peptide powder and 55-65% of core function compound powder. According to the invention, egg white protein peptide is used as a high-quality matrix, and nine specific medicinal materials including hippocampus, egg yolk phospholipid, egg membrane peptide, walnut, fructus alpiniae oxyphyllae, gastrodia elata, mulberry, sargassum fusiforme, wolfberry, ginkgo leaf, fructus evodiae and dandelion are cooperatively compatible; aiming at seven core pathological links of Alzheimer's disease, such as A beta deposition, Tauopathy, neuroinflammation, oxidative stress, cholinergic deficiency, neurodystrophy and cerebral circulation disorder, a multi-target synergistic effect network is constructed, comprehensive neuroprotection is realized, and tests prove that the space learning and memory ability and the autonomous activity ability can be effectively improved.

The application discloses a point application traditional Chinese medicine composition with an effect of treating irritable bowel syndrome, a point application plaster and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The application provides a point application traditional Chinese medicine composition and a point application plaster. The traditional Chinese medicine composition comprises the following components: psoralea, radix codonopsis, dried zedoary, fried atractylodes, mace, schisandra chinensis and evodia. The composition is prepared according to the principle of less medicine and special function and treatment of disease and seeking the origin. The core tonifying medicine, psoralea, dried zedoary and radix codonopsis, has a prominent dosage proportion and remarkable effects of warming the spleen and kidney yang and invigorating the spleen and replenishing qi. The application finds through clinical research that the clinical total effective rate of the test group is 76.7%, the curative effect is accurate and better than that of a placebo, the IBS-SSS score, the TCM syndrome score and the stool character score of IBS patients can be reduced, the symptoms of the patients are improved, and the composition can effectively treat IBS.

The invention discloses a composition, a medicine containing the composition, a combined medicine and application. The composition comprises fructus evodiae or other qi promoting components, a blood stasis dispersing component, a middle-jiao warming, cold dispelling and spleen tonifying component, liquorice, a blood generating and activating component, a wind-cold dispersing component and a kidney reinforcing component. The composition disclosed by the invention has a good antiviral effect, and can assist qi and blood generation so as to transform cold-dampness, so that antiviral effect is realized, and meanwhile, the body function is improved.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following raw materials: fructus evodiae, salted fennel, combined spicebush root, piper cubeba, radix aconiti lateralis preparata, cassia twig, clove, vinegar frankincense, vinegar myrrh and angelica sinensis. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 10 parts of fructus evodiae, 15 parts of salted fennel, 10 parts of radix linderae, 10 parts of piper cubeba, 30 parts of radix aconiti lateralis preparata, 10 parts of cassia twig, 10 parts of clove, 10 parts of vinegar frankincense, 10 parts of vinegar myrrh and 10 parts of angelica sinensis. The traditional Chinese medicine composition disclosed by the invention is combined with the syndrome of congealing cold with blood stasis, utilizes the treatment method of mainly warming and dredging and also activating and nourishing blood, is synergistic in all the medicines and tightly focuses on the mechanism of congealing cold with blood stasis, so that cold evil is dissipated, qi and blood are warm, stasis is promoted, qi and blood of Chong and Ren channels are harmonized, menstrual blood flows smoothly, and pains are stopped.

The application discloses a traditional Chinese medicine composition for treating pancreatic cancer, which comprises the following medicinal materials in parts by weight: 1-20 parts of Chinese cork tree, 1-15 parts of ginkgo, 1-10 parts of evodia, 1-10 parts of tripterygium, 1-15 parts of two-edged needle, 1-15 parts of radix astragali, and 1-10 parts of jujube. The application further discloses a medicine taking the traditional Chinese medicine composition as raw materials and a preparation method of the medicine. In addition, the application further discloses application of the traditional Chinese medicine composition or the medicine in preparation of a medicine for treating pancreatic cancer.

The invention belongs to the technical field of traditional Chinese medicine navel patches, and particularly relates to a composite medicine carrying navel therapy patch based on a PU film and a preparation method thereof.The composite medicine carrying navel therapy patch comprises an anti-sticking release film, a medicine carrying layer, a medical pressure-sensitive adhesive layer and a PU waterproof protective layer; the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10 to 20 parts of rhizoma zingiberis, 10 to 15 parts of roasted rhizoma atractylodis macrocephalae, 8 to 12 parts of radix codonopsis, 5 to 10 parts of fructus evodiae, 5 to 10 parts of fructus foeniculi, 3 to 8 parts of cortex cinnamomi, 1 to 3 parts of borneol, 8 to 20 parts of polysorbate 80, 0.5 to 2 parts of carbomer 940, 1 to 3 parts of triethanolamine and 0.1 to 0.5 part of EDTA-2Na. By means of the integrated design of slow-release hydrogel drug loading and the multi-layer patch, efficient transdermal absorption and stable release of drugs are achieved, and the bioavailability and application comfort of the composite drug-loading navel therapy patch are improved.

The invention discloses a traditional Chinese medicine composition for assisting a tumor patient in warming yang, removing stasis and easing pain and a hot compress bag thereof, and relates to the technical field of external hot compress traditional Chinese medicines, the traditional Chinese medicine composition comprises the following raw materials: radix aconiti lateralis preparata, rhizoma zingiberis, fructus evodiae, pericarpium zanthoxyli, fennel, astragalus membranaceus, angelica sinensis, cinnamon, fried semen raphani and honey-fried licorice root. The traditional Chinese medicine formula takes the idea of strengthening yang as the core, follows the formula logic of strengthening yang to strengthen the root and eliminating evil without hurting healthy qi, accurately accords with the physical characteristics of'deficiency of healthy qi and stasis of evil toxin 'of tumor patients, directly strikes the core pathogenesis of'deficiency of yang-congealing cold-stasis toxin' of cancer patients through the compatibility of medicinal materials for warming and strengthening congenital kidney yang, warming and dredging meridian stasis, tonifying qi, nourishing blood and strengthening body resistance, and has a remarkable curative effect. The traditional Chinese medicine composition is capable of conditioning yang-deficiency constitution, realizing dual goals of relieving symptoms and improving constitution, preventing pathological vicious circle, enabling conditioning to be more fundamental, and avoiding the limitation that only surface symptoms are relieved and are not treated fundamentally.

The application belongs to the technical field of medicines, and particularly relates to an ester group substituted evodiamine derivative, a preparation method and application, and a structural formula is as follows: The application shows excellent inhibitory activity on HT-29, HTC-116, LOVO, RKO, HGC-27, MGC-803, SGC-7901, Huh7, SK-EP1 and MCF-7 tumor cell lines, and can show good antitumor activity at an animal level.

The invention provides an umbilicus application suppository for treating constipation and a preparation method thereof, and relates to the technical field of medicine.The umbilicus application suppository for treating constipation comprises a suppository body, the suppository body comprises a suppository matrix and a traditional Chinese medicine microcapsule, and the traditional Chinese medicine microcapsule comprises an emulsified oil phase, an emulsified water phase and a traditional Chinese medicine composition; the traditional Chinese medicine composition comprises rheum officinale, fructus cannabis, bunge cherry seeds, astragalus membranaceus, ginseng, immature bitter oranges, mangnolia officinalis, rhizoma atractylodis, radix sophorae flavescentis, golden cypress, fructus cnidii and fructus evodiae. A transdermal promotion mechanism is designed and optimized by adopting a traditional Chinese medicine micro-capsule structure, and a specific traditional Chinese medicine composition and a micro-encapsulation process are combined, so that the transdermal absorption efficiency of the medicine is effectively improved, the skin irritation reaction is reduced, and meanwhile, the stable slow release of the medicine is realized, thereby solving the problems of low transdermal absorption efficiency, large effect fluctuation, poor skin compatibility and the like in the prior art; the preparation has the advantages of high transdermal absorption efficiency, small skin irritation, good drug sustained release performance and the like.

The application discloses a model for evaluating microtoxicity of evodia extract based on fruit fly behavior and a construction method and application thereof, and belongs to the technical field of toxicity evaluation. In order to accurately, quickly and efficiently evaluate the microtoxicity of the evodia extract, avoid the fluctuation of the corresponding indexes of each behavior experiment of the fruit fly and better reflect the olfactory and gustatory behaviors of the fruit fly, the application successively connects a bidirectional selection feeding experiment, a Y type experiment and a proboscis extension experiment to construct a model for evaluating the microtoxicity of the evodia extract based on the fruit fly behavior, and the model has the characteristics of high accuracy, quickness and high efficiency and can be used for evaluating whether the evodia extract solution reaches a lethal concentration.

This invention belongs to the field of pharmaceutical application technology, specifically relating to an antifungal evodiamine derivative and its use in the preparation of antifungal substances. The structural formula of the evodiamine derivative is as follows: R1, R2, and R3 are independently H, halogen, or C1-3 alkyl groups; n1 is 1-3; the group is located at the 1, 3, or 4 position of the benzene ring; R4, R5, and R6 are independently C1-3 alkyl groups. The evodiamine derivative has an antifungal effect, especially against Trichophyton rubrum or Trichophyton mentagrophytes, expanding the selection range of antifungal drugs, reducing the possibility of drug-resistant strains, and improving the inhibitory effect on drug-resistant bacteria.

The invention discloses a traditional Chinese medicine composition for treating chronic gastritis, and relates to the technical field of traditional Chinese medicines. The main functional component of the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of parched white peony root, 10-20 parts of radix curcumae, 6-15 parts of radix aucklandiae, 3-9 parts of fructus amomi, 5-15 parts of fructus evodiae, 15-25 parts of cuttlebone, 10-20 parts of astragalus membranaceus, 10-20 parts of codonopsis pilosula, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of pinellia ternate, 15-25 parts of poria cocos, 10-20 parts of roasted rhizoma atractylodis macrocephalae, 10-20 parts of cassia twig and 3-9 parts of honey-fried licorice root. The compatibility of the traditional Chinese medicine composition conforms to the principle of'monarch, minister, assistant and guide 'of traditional Chinese medicines, and all the medicines are synergistic to strengthen the spleen, treat root causes, regulate qi to alleviate pain and simultaneously regulate the liver and the spleen; the effects of reducing phlegm and dampness, harmonizing the stomach, dispelling cold and treating both symptoms and root causes are achieved. The traditional Chinese medicine is high in clinical gastritis patient treatment efficiency, safe and free of side effects.

The application relates to the technical field of compound medicines, and discloses application of a compound external-use patch for preventing and treating diabetic peripheral neuropathy, wherein the compound external-use patch comprises a gel base and dry extract and volatile oil doped into the gel base, the dry extract and the volatile oil are derived from a compound, and the compound is composed of 10-20 parts of cinnamon, 8-12 parts of asarum, 8-12 parts of evodia, 8-12 parts of chuanxiong and 0.2-0.8 parts of borneol in terms of weight parts. The compound external-use patch of the application is locally pasted on acupoints or joints of DPN rats, can reduce the blood sugar level of diabetic peripheral neuropathy rats, increase the insulin level, improve insulin resistance, prolong the latent period of hot stimulation foot withdrawal, increase the nerve conduction velocity, maintain the normal morphology and function of nerve cells, and therefore can prevent and inhibit the generation and deterioration of diabetic peripheral neuropathy; and the compound external-use patch improves the safety and convenience of patients in taking medicine compared with oral medicine.

The invention provides a plant extraction gel for improving vaginal elasticity and a preparation method and application thereof, and belongs to the technical field of biological medicine. The plant extraction gel is prepared from fructus evodiae extract, Chinese herbaceous peony root extract, rhodomyrtus tomentosa fruit extract, dogwood extract, lime peel extract, cyrtomium rhizome extract, zedoary turmeric oil, melaleuca alternifolia oil, rosemary leaf oil, matrine and auxiliary materials. According to the invention, the fructus evodiae extract increases the thickness, the wettability and the elasticity of a vaginal wall by simulating an estrogen function; the Chinese herbaceous peony root extract has anti-inflammatory and anti-oxidation effects. The rhodomyrtus tomentosa fruit extract can tighten tissues in time, the dogwood extract can improve microcirculation and provide nutrition, and the lime peel extract can protect the elastic fibers from oxidative damage. All the components in the plant extraction gel supplement each other, and the comprehensive effect of recovering and maintaining vagina elasticity is achieved together. The plant extract gel disclosed by the invention has obvious effects in balancing vaginal flora and improving vaginal elasticity.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a navel therapy composition and a navel therapy preparation for preventing and treating abdominal pain caused by intravenous drip of azithromycin in children and a preparation method of the navel therapy composition and the navel therapy preparation. The technical key points are as follows: the fructus evodiae and the dysentery are combined according to a specific weight ratio, and are matched with pharmaceutic adjuvants such as a transdermal enhancer and an excipient to prepare special navel therapy dosage forms such as pills, cakes, patches and the like. According to the composition, by utilizing the characteristics that the Shenque acupoint (navel) epidermal cuticle is thin, the barrier function is weak, blood vessels are rich, and medicines are easy to disperse and absorb, adverse reactions such as gastrointestinal spasmodic pain, nausea and vomiting and the like caused by intravenous drip of azithromycin in children are effectively relieved through an administration mode of external application. Through clinical verification, the umbilical therapy preparation can remarkably reduce the incidence rate and severity score of stomachache, vomiting and diarrhea, and remarkably improve the treatment compliance of child patients.

The invention discloses a wind-dispelling and pain-relieving plaster for treating wind-cold migraine and application thereof, and belongs to the technical field of traditional Chinese medicine, the wind-dispelling and pain-relieving plaster is prepared from the following medicinal raw materials in parts by mass: ligusticum wallichii, asarum, fructus evodiae, radix angelicae and borneol; the invention further discloses a preparation method and application of the traditional Chinese medicine composition. The wind-dispelling and pain-relieving patch has the beneficial effects that the wind-dispelling and pain-relieving patch provided by the invention avoids gastrointestinal tract injury caused by alimentary tract metabolism of medicines in a transdermal administration manner, avoids cardiovascular contraindications of triptan medicines, is particularly suitable for patients who are intolerant to western medicines or have contraindications, not only can quickly relieve pain, but also can reduce the recurrence frequency, and has a good application prospect. In addition, treatment is carried out by applying the Dazhui acupoint application, operation is easy and convenient, no wound is caused, patient compliance is high, and exertion of the curative effect is better facilitated, so that the anxiety emotion is relieved, and the life quality is improved.

The invention relates to a plant extraction complexing agent as well as a preparation method and application thereof. The plant extraction complexing agent is prepared from the following raw material components: rhizoma zingiberis, flos caryophylli, cortex cinnamomi, herba schizonepetae, fructus evodiae, radix aucklandiae, pepper, fennel, herba asari, pericarpium zanthoxyli, fistular onion stalk and radix ginseng. The hot-pungent / warm-pungent herbal medicine plants are selected and contain rich volatile oil, and sesquiterpenoids, monoterpenoids and aromatic compounds contained in the latter have a transdermal penetration enhancing effect, are suitable for in-vitro application, have the effects of stimulating an immune system, resisting inflammation, resisting viruses, easing pain and the like and are prepared into the instant granules through a special proportion formula. When in use, the sauna / atomization mode is utilized to promote the active ingredients to enter the body to stimulate the immune system so as to achieve the anti-inflammatory and anti-virus effects. The plant extract complexing agent provided by the invention can increase the total number of leukocytes, increase the number of lymphocytes and adjust the percentage distribution of unbalanced neutrophils and lymphocytes to tend to be normalized, and the effect shows a good dose-effect relationship.

The invention discloses a traditional Chinese medicine composition for treating eczema, which is prepared from the following raw material components in parts by weight: 15-30 parts of garden burnet, 10-15 parts of radix sophorae flavescentis, 3-10 parts of coptis chinensis, 3-9 parts of fructus evodiae, 10-15 parts of cortex dictamni, 6-15 parts of fructus cnidii, 6-12 parts of angelica sinensis and 10-30 parts of radix rehmanniae recen. The medicinal materials in the formula interact with one another, the fructus evodiae can be used for assisting bitter cold and warming yang and drying dampness, the angelica sinensis and the radix rehmanniae recen can be used for regulating qi, blood, yin and yang, so that the medicine property of the whole formula tends to be mild, the effects of the medicinal materials are synergistically exerted, and the aim of treating eczema is jointly achieved.

The invention belongs to the field of biological pharmacy, and particularly discloses application of evodiamine in inhibition of migration and invasion of gallbladder cancer cells and metastatic tumor growth. Aiming at the problems of poor drug targeting, high toxicity, easy drug resistance and the like in gallbladder cancer hepatic metastasis treatment, the invention provides various application forms of evodiamine: 1) an evodiamine single-drug sustained release preparation (PLGA or chitosan carrier) realizes long-acting sustained release through local intervention or intratumor injection; 2) the evodiamine liposome preparation (the ratio of DPPC to cholesterol is 3: 1, and the particle size is 80-150nm) can improve the enrichment rate of hepatic metastatic focus to 5.8% or above; (3) the evodiamine and chemotherapeutic drugs (oxaliplatin, 5-FU and the like) are combined to form a composition, and the synergy index is Cilt; 0.8, the toxicity of the system is obviously reduced; animal experiments show that the liver metastasis inhibition rate reaches 82.7% and the weight loss rate is only 10.5% when the liposome (3 mg / kg of evodiamine and 6 mg / kg of oxaliplatin) is combined, and a high-efficiency and low-toxicity solution is provided for gallbladder carcinoma metastasis.

The present application relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition, a preparation method and application thereof. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: cassia twig 10-20 parts, fennel 20-30 parts, bupleurum 15-30 parts, angelica 8-15 parts, evodia 2-5 parts, white peony root 4-10 parts, licorice 5-10 parts, cassia 16-26 parts, and tuckahoe 9-17 parts. The preparation method comprises the following steps: preparing fennel extract, tuckahoe extract, cassia twig extract, bupleurum extract, angelica extract, white peony root extract, licorice extract, and cassia extract, mixing the above extracts to obtain a mixed extract, and soaking evodia in the mixed extract to obtain the traditional Chinese medicine composition by reflux extraction. In the present application, the main drug can warm the meridians and dispel cold, the auxiliary drug can invigorate blood and warm channels, and can also nourish the liver and yin, so that the main drug can achieve better effect. The main drug, the auxiliary drug and the auxiliary auxiliary drug can achieve synergistic effect, and are indispensable.

The invention discloses a medicine composition containing evodiamine, a medicine carrying system and application of the medicine carrying system in osteoarthritis, and belongs to the technical field of biological medicine. It is found for the first time that evodiamine can significantly inhibit cartilage cell apoptosis and promote cartilage cell proliferation; the brand new pharmacological activity provides a brand new candidate compound for the treatment of osteoarthritis. In order to further improve the curative effect, evodiamine and a medicine combination capable of intervening in macrophage polarization or adjusting the joint inflammation microenvironment are designed, the medicine combination can act on two key pathological links of cartilage repair and inflammation adjustment at the same time, and the treatment effect of osteoarthritis is greatly improved through the synergistic effect.

The invention provides a traditional Chinese medicine composition for treating lung cancer, and relates to the technical field of traditional Chinese medicine pharmacy. Specifically, the traditional Chinese medicine composition for treating lung cancer is prepared from radix aconiti preparata, rhizoma pinelliae preparata, radix asteris, rhizoma curcumae, poria cocos, cortex moutan, prepared fructus evodiae, ginseng, pericarpium zanthoxyli and liquorice, and has the effects of warming yang, dispelling cold, reducing phlegm, removing stasis, tonifying qi and strengthening the body resistance. Proliferation and migration of cancer cells can be effectively inhibited, and apoptosis of the cancer cells is promoted; the compound has an obvious treatment effect on tumor model mice, can obviously improve the survival state of the tumor model mice, has an obvious expression inhibition effect on a cell proliferation marker Ki-67, realizes an obvious inhibition effect on tumor growth, and can obviously improve the pathological morphology of tumor tissues. The traditional Chinese medicine composition provided by the invention provides a new direction for the development of medicines for treating lung cancer.

The invention belongs to the field of new drug design and synthesis, and relates to a synthesis method of a 10-arylamino evodiamine derivative, the 10-arylamino evodiamine derivative is shown as a formula 4, and R is selected from H, alkyl, alkoxy or fused aryl. The synthetic route comprises the following steps: (1) taking 10-hydroxyevodiamine (1) as a raw material, and reacting with trifluoromethanesulfonic anhydride (Tf2O) under proper conditions to obtain 10-trifluoromethanesulfonyloxy evodiamine 2; (2) reacting the compound 2 with an arylamine reagent 3 under proper conditions to obtain a 10-arylamine evodiamine derivative 4; wherein R of the arylamine reagent 3 in the step (2) is selected from H, alkyl, alkoxy or fused aryl. The 10-arylamino evodiamine derivative 4 synthesized by the invention shows good anti-cancer activity on liver cancer cells and neuroblastoma cells, and can be applied to preparation of corresponding anti-tumor drugs.

The rutaecarpin and the derivative thereof are synthesized by using a hydrogen borrowing reaction strategy. In an experiment, ethylene glycol is used as a solvent and an alkylating reagent, and the ethylene glycol and a substrate are subjected to a heating reaction in the presence of an iridium-based catalyst under an alkaline condition to prepare a target product. In the reaction process, two hydroxyl groups in the ethylene glycol are respectively and successively converted into formyl groups, and then a nucleophilic addition reaction of aldehyde is carried out; and the alkylation reaction is completed through the steps of dehydration, reduction and the like. In the whole reaction process, hydrogen and other reducing agents do not need to be additionally added, and only water serves as a byproduct. Therefore, from the perspective of synthetic chemistry and environmental protection, the hydrogen borrowing reaction method has the characteristics of high efficiency and greenness, and has a wide application prospect.

The invention provides a traditional Chinese medicine composition for treating diarrhea-type irritable bowel syndrome. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: radix paeoniae alba, hypericum perforatum, codonopsis pilosula, rhizoma atractylodis macrocephalae, semen cuscutae, fructus evodiae, rhizoma zingiberis, fructus amomi rotundus, schisandra chinensis and radix curcumae. The traditional Chinese medicine composition has the effects of warming kidney and strengthening spleen, soothing liver-qi stagnation and relieving diarrhea with astringents. The traditional Chinese medicine composition disclosed by the invention has an outstanding clinical effect on treating the diarrhea-type irritable bowel syndrome, and particularly has an obvious curative effect on patients with abdominal distension, abdominal pain, diarrhea, belching, dysphoria, dull pain, bitter mouth, light tongue, white and smooth tongue coating and deep and thin pulse caused by spleen-kidney yang deficiency, liver-qi stagnation and intestinal dysfunction.

The application is suitable for the technical field of traditional Chinese medicine, and provides an acupoint sticking traditional Chinese medicine composition for treating AIDS combined with insomnia, an acupoint patch and a preparation method thereof, wherein the acupoint sticking traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 10-30 parts of angelica, 10-30 parts of astragalus, 20-50 parts of radix polygoni multiflori, 10-30 parts of albizia, 5-15 parts of cassia, 10-30 parts of acorus, 5-15 parts of evodia, 10-30 parts of radix paeoniae alba, 5-15 parts of mentha and 10-30 parts of semen platycladi. The application strictly follows the theory of traditional Chinese medicine to formulate the prescription, and the various medicinal materials are synergized by virtue of unique efficacy and meridian characteristics, combined with the meridians of traditional Chinese medicine, the theory of traditional Chinese medicine and modern pharmacology, and various acupoint selection methods are used to select acupoints, and the application adopts "one acupoint one medicine" to treat AIDS combined with insomnia by "waking up in the day and calming down at night", and the acupoint sticking operation is simple and low in cost.

The application relates to the technical field of medicines, and provides a preparation method of a new amide alkaloid compound, i.e., wuzhuyu amide B (1-methyl-3-(2-(quinazolin-4-yl)ethyl)quinazoline-2,4(1 H ,3 H )‑dione) with tumor disease treatment and the use in the medical field for treating cancer, which can be used in the medical field.

The traditional Chinese medicine composition for promoting growth of children comprises the following components in parts by weight: 6-10 parts of clove, 6-10 parts of cinnamon, 10-20 parts of fructus evodiae, 15-25 parts of scorched hawthorn fruit, 15-25 parts of fried endothelium corneum gigeriae galli, 5-10 parts of fried bighead atractylodes rhizome, 10-20 parts of medicated leaven, 10-20 parts of astragalus membranaceus, 2-5 parts of pseudo-ginseng powder and 10-20 parts of eucommia ulmoides. The growth and development of children are promoted through the synergistic effects of regulating spleen and stomach transportation and transformation, nourishing liver and kidney, promoting blood circulation to remove blood stasis and the like.

This invention belongs to the field of pharmaceutical technology, specifically relating to a water-soluble evodiamine derivative and its application, with the following structural formula: wherein X is a C1-6 alkylene group or X together with R forms R1 and R2 independently selected from hydroxyl or C1-20 alkoxy groups; R is a hydroxyl group with or without alkylene group, a carboxyl group with or without alkylene group, a C1-20 oxane group, an amino group, a substituted amino group with or without alkylene group, or a heterocyclic amino group with or without alkylene group. This invention can improve its water solubility and antitumor effect.