Traditional Chinese medicine preparation for treating gastrointestinal diseases

Abstract

The invention provides a traditional Chinese medicine preparation for treating gastrointestinal diseases, and relates to the technical field of traditional Chinese medicine, and the traditional Chinese medicine preparation for treating gastrointestinal diseases comprises the following components in parts by weight: 6-10 parts of cuttle bone, 1-2 parts of thunberg fritillary bulb, 4-6 parts of bletilla striata, 2-4 parts of pericarpium citri reticulatae, 5-8 parts of calcined corrugated seed, 2-4 parts of pseudo-ginseng, 1-3 parts of combined spicebush root, 2-4 parts of corydalis tuber, 2-4 parts of microcos paniculata, 2-4 parts of fried madder and 2-4 parts of coptis chinensis. The traditional Chinese medicine composition is prepared from 2-4 parts of fructus mume, 0.5-2 parts of cortex cinnamomi, 1-4 parts of radix salviae miltiorrhizae, 1-4 parts of radix angelicae sinensis, 1-4 parts of radix paeoniae alba, 0.5-2 parts of fructus evodiae, 2-4 parts of crinis trachycarpi, 2-4 parts of herba agrimoniae, 1-4 parts of fried pollen typhae and 1-4 parts of carbonized sanguisorba root. According to the method for treating gastrointestinal diseases provided by the invention, a plurality of Chinese herbal medicines including cuttle bone, thunberg fritillary bulb, bletilla striata, dried orange peel, calcined corrugated seed, pseudo-ginseng and combined spicebush root are used as basis, and are accurately proportioned and processed according to respective medicinal characteristics and medicinal effects; and a unique formula for soothing liver and strengthening spleen, regulating cold and heat, astringing to stop bleeding, diminishing swelling and promoting tissue regeneration, relieving hyperacidity and pain, and protecting and repairing gastrointestinal mucosa is formed.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine preparation for treating gastrointestinal diseases. Background Art

[0002] In the field of traditional Chinese herbal medicine, the treatment of gastrointestinal diseases has always been a matter of great concern. Gastrointestinal diseases, such as chronic gastritis, gastric erosion, gastric ulcer, duodenal ulcer, etc., are often accompanied by a decrease in the quality of life of patients and a threat to their physical health. The traditional Chinese herbal medicine method for treating gastrointestinal diseases mainly relies on the decoction, grinding and compatibility of herbs. However, due to certain limitations in the proportion of ingredients, stability of efficacy and therapeutic effect of traditional preparation methods, it is necessary to seek a more scientific and accurate treatment method. Summary of the invention

[0003] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a Chinese medicine preparation for treating gastrointestinal diseases.

[0004] In order to achieve the above object, the present invention adopts the following technical scheme: a Chinese medicine preparation for treating gastrointestinal diseases, wherein the formula for treating gastrointestinal diseases comprises the following components in parts by weight:

[0005] 6-10 parts of cuttlefish bone, 1-2 parts of Fritillaria thunbergii, 4-6 parts of Bletilla striata, 2-4 parts of dried tangerine peel, 5-8 parts of calcined Artemisia selengensis, 2-4 parts of Panax notoginseng, 1-3 parts of Linderae strychnifolia, 2-4 parts of Buza leaves, 2-4 parts of stir-fried Rubia cordifolia, 2-4 parts of Coptis chinensis, 2-4 parts of Prunus mume, 0.5-2 parts of cinnamon bark, 1-4 parts of Salvia miltiorrhiza, 1-4 parts of Angelica sinensis, 1-4 parts of White Peony Root, 0.5-2 parts of Evodia rutaecarpa, 2-4 parts of palm charcoal, 2-4 parts of Agrimoniae herb, 1-4 parts of stir-fried Pollen Typhae, and 1-4 parts of Sanguisorba officinalis charcoal.

[0006] Preferably, the cuttlefish bone is a shelled cuttlefish bone. Here, the shelled cuttlefish bone has a finer texture and a finer powder, which makes its absorption speed in the body relatively fast.

[0007] A Chinese medicine preparation for treating gastrointestinal diseases comprises the following steps:

[0008] S1, raw material processing: according to the types of raw materials and corresponding weights specified in the formula, accurate weighing operations are carried out. The key to preparing herbal formulas is to ensure the accurate proportion of each ingredient. Wash them separately, dry them, and crush them into coarse powder;

[0009] S2, extraction: mix the coarse powder evenly, add appropriate amount of water, soak for a certain period of time, and then heat and extract. The extraction times are 2-3 times, and each extraction time is 1-2 hours;

[0010] S3, filtration: filtering the extract to remove impurities;

[0011] S4, concentration: concentrating the filtered extract to obtain a concentrated solution;

[0012] S5, drying: drying the concentrated liquid to obtain Chinese medicine powder;

[0013] S6, Preparation: Prepare Chinese medicine powder into required dosage forms, such as tablets, capsules, granules, etc.

[0014] Preferably, in step S2, soaking time: the optimal soaking time is determined to be 1.5 hours through experiments; number of extractions and time: after multiple experiments, the number of extractions is determined to be 3 times, and the time for each extraction is 1.5 hours.

[0015] Preferably, in step S4, the concentration temperature and pressure are as follows: the reduced pressure concentration method is adopted, and the optimal concentration temperature is determined to be 60-70°C and the pressure is -0.08MPa.

[0016] Preferably, in step S5, the drying method is: a spray drying method is used, and the optimal drying conditions are determined to be an inlet temperature of 180-200°C and an outlet temperature of 80-90°C.

[0017] Preferably, in steps S1-S6, (1) raw material quality control: strictly control the source, origin, harvesting time, etc. of the raw materials to ensure that the quality of the raw materials meets the requirements;

[0018] (2) Extraction process control: strictly control the extraction temperature, time, number of times, etc. to ensure the extraction effect;

[0019] (3) Concentration and drying process control: Strictly control the concentration temperature, pressure, drying conditions, etc. to ensure the stable quality of traditional Chinese medicine;

[0020] (4) Preparation process control: Strictly control the process parameters and quality standards of the preparation to ensure that the quality of the preparation meets the requirements.

[0021] Compared with the prior art, the advantages and positive effects of the present invention are:

[0022] The method for treating gastrointestinal diseases provided by the present invention is based on multiple Chinese herbal medicines such as cuttlefish bone, fritillaria thunbergii, white striata, tangerine peel, calcined radix spatholobi, notoginseng, and lindera striata, and according to their respective medicinal properties and efficacy, through precise proportioning and processing, a unique formula is formed for soothing the liver and strengthening the spleen, balancing cold and heat, astringing and stopping bleeding, reducing swelling and promoting tissue regeneration, reducing acid and relieving pain, and protecting and repairing the gastrointestinal mucosa. The breakthrough point of this technology lies in the scientific combination and precise proportioning of traditional Chinese herbal medicines, and the fine control of the preparation process. The efficacy stability and preparation quality of the formula are guaranteed through accurate weighing, meticulous washing and drying, fine grinding and screening, and strict preparation process. In addition, the herbs selected in the formula have multiple efficacy, including soothing the liver, strengthening the spleen, relieving pain, stopping bleeding, etc., and can comprehensively treat the symptoms of gastrointestinal diseases, providing patients with a more comprehensive and effective treatment plan. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 A schematic diagram of the steps of a Chinese medicine preparation for treating gastrointestinal diseases is provided in the present invention;

[0024] Figure 2 The present invention provides an electronic gastroscopy image before treatment in a traditional Chinese medicine preparation for treating gastrointestinal diseases;

[0025] Figure 3 The present invention provides an electronic gastroscopy image before treatment in a traditional Chinese medicine preparation for treating gastrointestinal diseases;

[0026] Figure 4 The present invention provides an electronic gastroscopy image after treatment in a traditional Chinese medicine preparation for treating gastrointestinal diseases. DETAILED DESCRIPTION

[0027] In order to more clearly understand the above-mentioned purpose, features and advantages of the present invention, the present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

[0028] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments of the following disclosure.

[0029] The raw materials in the embodiments can be obtained commercially;

[0030] Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the present technical field.

[0031] Example 1

[0032] A traditional Chinese medicine tablet for treating gastrointestinal diseases is composed of the following raw materials in parts by weight: 6-10 parts of cuttlefish bone, 1-2 parts of fritillaria thunbergii, 4-6 parts of bletilla striata, 2-4 parts of dried tangerine peel, 5-8 parts of calcined aralia strychni, 2-4 parts of notoginseng, 1-3 parts of lindera striata, 2-4 parts of bupleurum sibiricum, 2-4 parts of stir-fried madder, 2-4 parts of coptis root, 2-4 parts of ebony, 0.5-2 parts of cinnamon bark, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of white peony root, 0.5-2 parts of evodia rutaecarpa, 2-4 parts of palm charcoal, 2-4 parts of agrimony, 1-4 parts of stir-fried pollen pollen and 1-4 parts of sanguisorba officinalis charcoal.

[0033] The preparation method is as follows:

[0034] (1) Wash the raw materials separately, dry them, and grind them into coarse powder.

[0035] (2) Mix the coarse powder evenly, add appropriate amount of water, and soak for 1.5 hours.

[0036] (3) Perform three heating extractions, each time for 1.5 hours.

[0037] (4) Filter the extract to remove impurities.

[0038] (5) The filtered extract is concentrated under reduced pressure at a temperature of 65° C. and a pressure of −0.08 MPa to obtain a concentrated solution.

[0039] (6) The concentrated liquid is spray-dried with an inlet temperature of 190° C. and an outlet temperature of 85° C. to obtain a Chinese medicine powder.

[0040] (7) Add appropriate amount of auxiliary materials to the Chinese medicine powder to make granules.

[0041] Example 2

[0042] A traditional Chinese medicine capsule for treating gastrointestinal diseases is composed of the following raw materials in parts by weight: 8-10 parts of cuttlefish bone, 2-3 parts of fritillaria thunbergii, 3-6 parts of bletilla striata, 1-4 parts of dried tangerine peel, 3-8 parts of calcined aralia strychni, 1-4 parts of notoginseng, 2-3 parts of lindera strychni, 1-4 parts of bupleurum sibiricum, 1-4 parts of stir-fried madder, 1-4 parts of coptis root, 1-4 parts of ebony, 0.5-2 parts of cinnamon bark, 2-4 parts of salvia miltiorrhiza, 2-4 parts of angelica sinensis, 2-4 parts of white peony root, 0.5-2 parts of evodia rutaecarpa, 2-4 parts of palm charcoal, 1-4 parts of agrimony, 1-4 parts of stir-fried pollen pollen and 1-4 parts of sanguisorba officinalis charcoal.

[0043] The preparation method is as follows:

[0044] (1) Wash the raw materials separately, dry them, and grind them into coarse powder.

[0045] (2) Mix the coarse powder evenly, add appropriate amount of water, and soak for 1.5 hours.

[0046] (3) Perform three heating extractions, each time for 1.5 hours.

[0047] (4) Filter the extract to remove impurities.

[0048] (5) The filtered extract is concentrated under reduced pressure at a temperature of 65° C. and a pressure of −0.08 MPa to obtain a concentrated solution.

[0049] (6) The concentrated liquid is spray-dried with an inlet temperature of 190° C. and an outlet temperature of 85° C. to obtain a Chinese medicine powder.

[0050] (7) Add appropriate amount of auxiliary materials to the Chinese medicine powder to make granules.

[0051] Example 3

[0052] A Chinese medicinal granule for treating gastrointestinal diseases is composed of the following raw materials in parts by weight: 12-14 parts of cuttlefish bone, 1-2 parts of fritillaria thunbergii, 4-6 parts of bletilla striata, 2-4 parts of dried tangerine peel, 5-8 parts of calcined aralia strychni, 2-4 parts of notoginseng, 1-3 parts of lindera striata, 2-4 parts of bupleurum sibiricum, 2-4 parts of stir-fried madder, 2-4 parts of coptis root, 2-4 parts of ebony, 0.5-2 parts of cinnamon bark, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of white peony root, 0.5-2 parts of evodia rutaecarpa, 2-4 parts of palm charcoal, 2-4 parts of agrimony, 1-4 parts of stir-fried pollen pollen and 1-4 parts of sanguisorba officinalis charcoal.

[0053] The preparation method is as follows:

[0054] (1) Wash the raw materials separately, dry them, and grind them into coarse powder.

[0055] (2) Mix the coarse powder evenly, add appropriate amount of water, and soak for 1.5 hours.

[0056] (3) Perform three heating extractions, each time for 1.5 hours.

[0057] (4) Filter the extract to remove impurities.

[0058] (5) The filtered extract is concentrated under reduced pressure at a temperature of 65° C. and a pressure of −0.08 MPa to obtain a concentrated solution.

[0059] (6) The concentrated liquid is spray-dried with an inlet temperature of 190° C. and an outlet temperature of 85° C. to obtain a Chinese medicine powder.

[0060] (7) Add appropriate amount of auxiliary materials to the Chinese medicine powder and put it into capsules to make capsules.

[0061] Example 4

[0062] Liu Jicang, male, 46 years old, had epigastric pain, stuffiness and blockage 3 years ago. He had electronic gastroscopy at Xi'an Central Hospital, which showed "chronic superficial gastritis erosion". The treatment with western medicine "omeprazole" and "cimetidine" was sometimes mild and sometimes severe. 5 days ago, after a dispute with a colleague, the symptoms worsened. He underwent electronic gastroscopy at the Second Affiliated Hospital of Xi'an Jiaotong University, which showed "chronic atrophic gastritis erosion". The pathological diagnosis showed moderate chronic atrophic gastritis with severe intestinal metaplasia and mild abnormal hyperplasia in the gastric antrum; epigastric distension and pain, burning sensation, belching, acid reflux, dry mouth and bitter mouth, upset, hot sweating, normal appetite, little sleep and dreaminess, dry and unfavorable stool, normal urination, purple tongue with ecchymosis, yellow and slightly greasy tongue coating, thin and stringy pulse. Diagnosis: chronic atrophic gastritis, intestinal metaplasia (severe) abnormal hyperplasia (mild). After using the above formula and method for one week, the symptoms were significantly alleviated, and after using it for 3 months, the symptoms disappeared.

[0063] Example 5

[0064] Wang Jun, male, 66 years old, is addicted to drinking. 15 years ago, due to drinking and irregular diet, he had epigastric distension and pain. The local hospital electronic gastroscopy showed chronic atrophic gastritis, and pathology showed mild intestinal metaplasia of chronic atrophic gastritis. He took Chinese and Western medicines such as "Omeprazole Enteric-coated Capsules", "Morodan", "Xiangsha Yangwei Pills", and "Sanjiu Weitai" for a long time, and his symptoms were sometimes mild and sometimes severe. He was diagnosed with diabetes 10 years ago and took hypoglycemic drugs such as "Metformin" and "Xiao Ke Pills" irregularly. This time, after drinking 5 days ago, his stomach pain and distension worsened, and he had nausea and vomiting, and the vomitus had a small amount of coffee color. He came to a hospital in Xi'an for an electronic gastroscopy, which showed: chronic atrophic gastritis erosion, gastric and duodenal bulb ulcers; pathological diagnosis showed: moderate chronic inflammation of the gastric body mucosa, acute activity, moderate intestinal metaplasia of the glands, antral mucosa and duodenal ulcers, Helicobacter pylori (+). After 1 week of hospitalization, the symptoms did not decrease, the body became thin, the complexion was dull, the stomach was bloated and painful, the painful area refused to be pressed, there was a feeling of fullness, nausea, acid reflux and heartburn, dry mouth and bitter mouth, poor appetite, fatigue, restless nights, dry and black stools, yellow urine, purple tongue with yellow greasy fur, and stringy pulse. Diagnosis: chronic atrophic gastritis with erosion, gastric and duodenal bulb ulcer, diabetes. After taking the above formula and method for 1 week, the symptoms were significantly alleviated, and continued for 3 months, except for slightly high blood sugar, the other symptoms disappeared.

[0065] Example 6

[0066] Xie Moumou, male, 48 years old, worker, began to experience abdominal distension and discomfort 3 years ago, accompanied by nausea and vomiting, heartburn and frequent diarrhea. Electronic gastroenteroscopy in the local hospital diagnosed him as "chronic non-atrophic gastritis" and "chronic colitis". He took Western medicine such as "Cimetidine", "Omeprazole Enteric-coated Capsules", "Norfloxacin" and "Metoclopramide" irregularly, and the pain recurred at irregular times and had no obvious correlation with eating. Recently, the distension and pain in the upper abdomen has worsened, mental fatigue, pale face, pain and discomfort in the upper abdomen and ribs, obvious tenderness, nausea and vomiting, belching, heartburn and pantothenic acid, poor appetite, irritability, restless nights, diarrhea 2-3 times a day, dark red tongue with thin white fur, and thin pulse. After taking the above formula and method for 5 days, the pain in the upper abdomen and ribs has disappeared, and the remaining symptoms have been alleviated. After 2 months of continuous use, the symptoms disappeared and diarrhea has stopped.

[0067] Example 7

[0068] See attached Figure 2-4 Liang Moumou, male, 40 years old, had epigastric pain due to work fatigue, irregular work and rest time, irregular diet, and excessive drinking one year ago. The pain worsened after eating. He went to a local hospital for treatment. Electronic gastroscopy showed gastric ulcer. He was given drugs such as "omeprazole", "fruit capsule", and "sunflower Weikangling". The symptoms improved after one month of oral administration. No gastroscopy was repeated. After that, the symptoms of epigastric pain recurred from time to time, and the medication was taken intermittently without systematic treatment. Ten days ago, the epigastric pain intensified after drinking, accompanied by a burning sensation, and the pain was obvious at night. He took "omeprazole", "fruit capsule", and "Weikangling" analgesics by himself, but the symptoms did not improve. On October 13, 2014, he went to the Nanfang Hospital of Southern Medical University for treatment. The electronic gastroscopy examination diagnosed him with chronic superficial gastritis with erosion and frosty ulcer of the duodenal bulb. The endoscopic pathological biopsy report showed chronic inflammation of the mucosa. Oral administration of "Rabeprazole Sodium Enteric-coated Tablets", "Pectin Secret", "Clarithromycin", and Chinese medicine "Xiangsha Yangwei Pills" and "Yuanhu Pain-relieving Tablets" for one week, but the effect was not relieved, the stomach pain was burning, obvious after eating, especially at night; the pain under the two hypochondria was uncomfortable, the appetite was poor, belching and pantothenic acid, fatigue, body weight loss, restless sleep, dry and black stool, normal urine. The tongue was purple and dark, the coating was yellow and greasy, and the pulse was stringy and slippery. Diagnosis: chronic superficial gastritis with erosion, frost-like ulcer in the duodenal bulb. After taking the above formula and method for 1 week, the above symptoms improved significantly, and continued for 3 months, the symptoms disappeared, and the electronic gastroscopy showed that the erosion and ulcer were cured.

[0069] Example 8

[0070] Mr. Li, male, 32 years old, worker, suffered from abdominal pain and diarrhea after eating raw, cold and spicy food 1 year ago, with loose stools 5-6 times / day. Gastroscopy and colonoscopy at a hospital in Guangzhou showed: chronic erosive gastritis and ulcerative colitis. Treatment with Chinese and Western medicine (unknown medication) was ineffective and recurrent. Pain and distension in the abdomen, poor appetite, hiccups, heartburn, and worsening pain and distension in the abdomen if the diet is not careful, more diarrhea, fatigue, 5-6 bowel movements per day, less urine, pale tongue with white greasy coating, and slow pulse. Diagnosis: chronic erosive gastritis and ulcerative colitis. After taking the above formula and method for 1 week, the symptoms were significantly relieved, and after 3 months of use, all the symptoms disappeared, and appetite and bowel movements were normal.

[0071] It can be seen from the above embodiments that based on multiple Chinese herbal medicines including cuttlefish bone, Fritillaria thunbergii, Bletilla striata, tangerine peel, calcined radix spatholobi, Panax notoginseng, and Linderae spatholobi, according to their respective medicinal properties and efficacy, after precise proportioning and processing, a unique formula is formed which can soothe the liver and invigorate the spleen, balance the cold and heat, astringe and stop bleeding, reduce swelling and promote tissue regeneration, reduce acid and relieve pain, and protect and repair the gastrointestinal mucosa. The breakthrough point of this technology lies in the scientific combination and precise proportioning of traditional Chinese herbal medicines, and the fine control of the preparation process. The efficacy stability and preparation quality of the formula are guaranteed through accurate weighing, meticulous cleaning and drying, fine grinding and screening, and strict preparation process.

[0072] The above are only preferred embodiments of the present invention and are not intended to limit the present invention in other forms. Any technician familiar with the profession may use the technical contents disclosed above to change or modify them into equivalent embodiments with equivalent changes and apply them to other fields. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A Chinese medicine preparation for treating gastrointestinal diseases, characterized in that: The formula for treating gastrointestinal diseases comprises the following components by weight: 6-10 parts of cuttlefish bone, 1-2 parts of Fritillaria thunbergii, 4-6 parts of Bletilla striata, 2-4 parts of dried tangerine peel, 5-8 parts of calcined Artemisia selengensis, 2-4 parts of Panax notoginseng, 1-3 parts of Linderae strychnos, 2-4 parts of Corydalis yanhusuo, 2-4 parts of Buza leaves, 2-4 parts of stir-fried Rubia cordifolia, 2-4 parts of Coptis chinensis, 2-4 parts of Prunus mume, 0.5-2 parts of cinnamon bark, 1-4 parts of Salvia miltiorrhiza, 1-4 parts of Angelica sinensis, 1-4 parts of White Peony Root, 0.5-2 parts of Evodia rutaecarpa, 2-4 parts of palm charcoal, 2-4 parts of Agrimoniae, 1-4 parts of stir-fried Pollen Typhae, and 1-4 parts of Sanguisorba officinalis charcoal.

2. The formula for treating gastrointestinal diseases according to claim 1, characterized in that: The cuttlefish bone is a shelled cuttlefish bone.

3. A Chinese medicine preparation for treating gastrointestinal diseases, characterized in that: The following steps are involved: S1, raw material processing: according to the types of raw materials and corresponding weights specified in the formula, accurate weighing operations are carried out. The key to preparing herbal formulas is to ensure the accurate proportion of each ingredient. Wash them separately, dry them, and crush them into coarse powder; S2, extraction: mix the coarse powder evenly, add appropriate amount of water, soak for a certain period of time, and then heat and extract. The extraction times are 2-3 times, and each extraction time is 1-2 hours; S3, filtration: filtering the extract to remove impurities; S4, concentration: concentrating the filtered extract to obtain a concentrated solution; S5, drying: drying the concentrated liquid to obtain Chinese medicine powder; S6, Preparation: Prepare Chinese medicine powder into required dosage forms, such as tablets, capsules, granules, etc.

4. The method for treating gastrointestinal diseases according to claim 3, characterized in that: In step S2, soaking time: the optimal soaking time is determined to be 1.5 hours through experiments; number of extractions and time: after multiple experiments, the number of extractions is determined to be 3 times, and the time for each extraction is 1.5 hours.

5. The method for treating gastrointestinal diseases according to claim 3, characterized in that: In step S4, the concentration temperature and pressure: the reduced pressure concentration method is adopted, and the optimal concentration temperature is determined to be 60-70°C and the pressure is -0.08MPa.

6. The method for treating gastrointestinal diseases according to claim 3, characterized in that: In step S5, the drying method is to use a spray drying method, and the optimal drying conditions are determined to be an inlet temperature of 180-200°C and an outlet temperature of 80-90°C.

7. The method for treating gastrointestinal diseases according to claim 3, characterized in that: In steps S1-S6, (1) raw material quality control: strictly control the source, origin, harvesting time, etc. of the raw materials to ensure that the quality of the raw materials meets the requirements; (2) Extraction process control: strictly control the extraction temperature, time, number of times, etc. to ensure the extraction effect; (3) Concentration and drying process control: Strictly control the concentration temperature, pressure, drying conditions, etc. to ensure the stable quality of traditional Chinese medicine; (4) Preparation process control: Strictly control the process parameters and quality standards of the preparation to ensure that the quality of the preparation meets the requirements.

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