Application of cis-methylisoeugenol in preparation of anti-depression drug

A kind of methyl isoeugenol, antidepressant technology, applied in the field of medicine

Inactive Publication Date: 2020-10-30
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no application of cis-methylisoeugenol in the preparation of antidepressant drugs

Method used

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  • Application of cis-methylisoeugenol in preparation of anti-depression drug
  • Application of cis-methylisoeugenol in preparation of anti-depression drug
  • Application of cis-methylisoeugenol in preparation of anti-depression drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] [Example 1] Effect of cis-methylisoeugenol on cumulative immobility time of mice forced to swim

[0025] Male ICR mice were used for 7 days to adapt to the new environment. Mice were divided into blank control group, cis-methylisoeugenol group [16.6, 50, 150 mg / (kg·d)], imipramine group [30 mg / (kg·d)], levodopa group [60 mg / (kg·d)] and galantamine group [1.5 mg / (kg·d)], 12 rats in each group, administered orally at 10:00 am every day for 7 days. One hour after the last administration, a forced swimming test was performed. The test was carried out in two days: on the first day, the mice were pre-swimmed in deep water at 22±2°C for 15 minutes, and after 24 hours, they were forced to swim for 6 minutes under the same conditions. That is, the mouse stops struggling or the mouse is in a floating state, and the limbs move slightly to keep the head above the water), the results are shown in figure 1 . The results showed that after the positive drug, cis-methylisoeugenol [1...

Embodiment 2

[0026] [Example 2] Effect of cis-methylisoeugenol on cumulative immobility time of tail suspension in mice

[0027] Male ICR mice were used for 7 days to adapt to the new environment. Mice were divided into blank control group, cis-methylisoeugenol group [16.6, 50, 150 mg / (kg·d)], imipramine group [30 mg / (kg·d)], levodopa group [60 mg / (kg·d)] and galantamine group [1.5 mg / (kg·d)], 12 rats in each group, administered orally at 10:00 am every day for 7 days. 1 h after the last administration, the tail suspension test was performed. About 1 cm away from the tip of the tail of the mouse, stick it on the bracket of the tail suspension box (25×25×30 cm) with adhesive tape, so that the mouse is in an upside-down state, and the hanging time is 6 minutes. Immobility time (that is, the mouse stops struggling or does not have any activity), the results are shown in figure 2 . The results showed that after the positive drug, cis-methylisoeugenol [16.6, 50, 150 mg / (kg·d)], levodopa, a...

Embodiment 3

[0028] [Example 3] Effects of cis-methylisoeugenol on body weight of chronic stress-depressed mice

[0029] Male C57 / BL6 mice were used for 7 days to adapt to the new environment. Except for the animals in the blank control group, the animals in the other groups were randomly given the following series of chronic stress stimuli: (1) noise for 2 h; (2) body restraint for 1 h; (3) wet cage for 15 h (add 200 mL of water to the cage) ); (4) cage tilt (45°) for 15 h; (5) strobe for 2 h; (6) fasting for 6 h; (7) forced swimming at 8°C for 6 min; (8) tail suspension for 6 min; ( 9) Day and night are reversed. The above stress stimuli were randomly arranged to be completed within one week and repeated for 6 weeks to establish a chronic stress depression model. Model mice were divided into model group, cis-methylisoeugenol group [16.6, 50, 150 mg / (kg·d)], imipramine group [30 mg / (kg·d)], levodopa group [60 mg / (kg·d)] and galantamine group [1.5 mg / (kg·d)], 12 rats in each group, were...

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Abstract

The invention discloses application of cis-methylisoeugenol in preparation of an anti-depression drug. The cis-methylisoeugenol has a remarkable effect of treating depression. According to the invention, cis-methylisoeugenol is made into an oral medicine for treating depression and the like.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to the medical application of cis-methyl isoeugenol, in particular to the application of cis-methyl isoeugenol in a medicine for effectively treating depression. Background technique [0002] Depression is a kind of mood disorder characterized by significant and persistent low mood, and it is one of the four major diseases in the world. In recent years, its prevalence has been increasing globally, and it has become the second largest human disease after coronary heart disease. The incidence of depression in my country is about 4%. Depressed patients cannot adapt to society and are high-risk groups of suicide, self-mutilation and self-abuse, which constitute a major social health crisis. Clinical studies have found that depression is also a complication of many diseases such as Parkinson's disease and diabetes, which brings serious neuropsychiatric burden to patients. Therefore, de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/085A61P25/24
CPCA61K31/085A61P25/24
Inventor 颜露韦敏宋萍萍钱怡云郑生智
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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