Pharmaceutical compositions for treating melancholia associated with functional dyspepsia and preparation

A technology for indigestion and composition, which is applied in the directions of drug combination, digestive system, medical preparations containing active ingredients, etc., can solve the problems of inconvenience in taking, too many flavors of prescriptions, serious problems, etc.

Inactive Publication Date: 2008-07-09
张作光
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Depression with functional dyspepsia is often clinically characterized by gastrointestinal symptoms, such as weakness of limbs, loss of appetite, nausea and anorexia, abdominal distension and pain, nausea and vomiting, etc., while mental factors and depression are covered up, so often only According to gastrointestinal dysfunction, the use of simple gastrointestinal motility drugs such as motiline is difficult to receive the expected curative effect
Of the mainstream antidepressant drugs sold in the market, only a few drugs such as Prozac have the function of direct symptomatic treatment of depression and associated functional dyspepsia, while drugs such as Seratra and Uleph do not have this effect
In addition, whether it is gastrointestinal motility drugs such as Domperidin or antidepressant drugs such as Prozac

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical compositions for treating melancholia associated with functional dyspepsia and preparation
  • Pharmaceutical compositions for treating melancholia associated with functional dyspepsia and preparation
  • Pharmaceutical compositions for treating melancholia associated with functional dyspepsia and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] See attached figure 1 , 8 kilograms of ginseng (conforming to the provisions of "The Pharmacopoeia of the People's Republic of China") are broken and decocted with 70% ethanol aqueous solution, separated and purified by chromatography, concentrated and dried to obtain 0.32 kilograms of ginseng extract; According to the Pharmacopoeia of the People's Republic of China), decoct and extract with 50% ethanol aqueous solution for crushing, separate and purify by chromatography, concentrate and dry to obtain 0.48 kg of Morinda officinalis extract; The aqueous solution was decocted, concentrated and dried to obtain 1.2 kg of Atractylodes macrocephala extract; the extracts obtained in the above steps were mixed to obtain the pharmaceutical extract composition of the present invention.

Embodiment 2

[0047] See attached figure 2 , directly mix 8 kilograms of ginseng, 8 kilograms of Morinda officinalis and 10 kilograms of Atractylodes macrocephala together with coarse powder, decoct with water or ethanol aqueous solution, concentrate and dry, and obtain the pharmaceutical extract composition of the present invention.

Embodiment 3

[0049] Directly use 4g ginsenoside (R g1 +R e +R b1 ) mixed with the ethanol extract (50% purity) of 96g Morinda officinalis and 120g water extract of Atractylodes Rhizoma Atractylodes Rhizome, to obtain the pharmaceutical extract composition of the present invention.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention discloses a medicine compound for curing melancholia and associated functional dyspepsia made from the raw materials including ginseng, morinda root and largehead atractylode. The present invention also discloses a preparation method of the medicine compound. The experiment proves that the medicine compound provided by the present invention can obviously reduce the immobility time in tail suspension of tested small mice and the accumulative immobility time in forced swimming of tested large mice, and promote the gastrointestinal power of tested large mice, thus inferring that the medicine compound provided by the present invention has the efficacy of resisting experimental melancholia and curing dyspepsia.

Description

technical field [0001] The invention relates to a group of pharmaceutical compositions for treating depression and associated functional dyspepsia, which can be used as medicine, health food and nutrition. [0002] The invention also relates to a preparation method of a group of pharmaceutical compositions for treating depression and associated functional dyspepsia. technical background [0003] Functional dyspepsia (FD) is a very common digestive system disease. According to domestic statistics, patients with functional dyspepsia account for more than 1 / 3 of outpatients in gastrointestinal specialist clinics, and the prevalence rate in developed countries such as Europe and the United States is as high as 20-40%. The pathogenesis of functional dyspepsia involves many factors, and the role of mental factors plays a very important role in its pathogenesis. A large number of studies have shown that the movement and secretion of the stomach are weakened or even stopped when p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/746A61K9/14A61K9/20A61K9/48A61P25/24A61P25/22A61P1/14A23L1/30
Inventor 张作光
Owner 张作光
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap