Pharmaceutical compositions for treating melancholia associated with functional dyspepsia and preparation

Abstract

The present invention discloses a medicine compound for curing melancholia and associated functional dyspepsia made from the raw materials including ginseng, morinda root and largehead atractylode. The present invention also discloses a preparation method of the medicine compound. The experiment proves that the medicine compound provided by the present invention can obviously reduce the immobility time in tail suspension of tested small mice and the accumulative immobility time in forced swimming of tested large mice, and promote the gastrointestinal power of tested large mice, thus inferring that the medicine compound provided by the present invention has the efficacy of resisting experimental melancholia and curing dyspepsia.

Description

technical field [0001] The invention relates to a group of pharmaceutical compositions for treating depression and associated functional dyspepsia, which can be used as medicine, health food and nutrition. [0002] The invention also relates to a preparation method of a group of pharmaceutical compositions for treating depression and associated functional dyspepsia. technical background [0003] Functional dyspepsia (FD) is a very common digestive system disease. According to domestic statistics, patients with functional dyspepsia account for more than 1 / 3 of outpatients in gastrointestinal specialist clinics, and the prevalence rate in developed countries such as Europe and the United States is as high as 20-40%. The pathogenesis of functional dyspepsia involves many factors, and the role of mental factors plays a very important role in its pathogenesis. A large number of studies have shown that the movement and secretion of the stomach are weakened or even stopped when p...

AI Technical Summary

Problems solved by technology

[0004] Depression with functional dyspepsia is often clinically characterized by gastrointestinal symptoms, such as weakness of limbs, loss of appetite, nausea and anorexia, abdominal distension and pain, nausea and vomiting, etc., while mental factors and depression are covered up, so often only According to gastrointestinal dysfunction, the use of simple gastrointestinal motility drugs such as motiline is difficult to receive the expected curative effect

Of the mainstream antidepressant drugs sold in the market, only a few drugs such as Prozac have the function of direct symptomatic treatment of depression and associated functional dyspepsia, while drugs such as Seratra and Uleph do not have this effect

In addition, whether it is gastrointestinal motility drugs such as Domperidin or antidepressant drugs such as Prozac, most of them have side effects of varying degrees, and some are even very serious.

[0005] There are many traditional Chinese medicine preparations for the treatment of dyspepsia, such as Sijunzi Decoction, Shenling Baizhu Powder, Weishukang Capsules and other drugs, which have certain curative effects in the treatment of functional dyspepsia, but are not effective in the treatment of depression and its accompanying functional dyspepsia. On the negative side, there is a lack of immediate effect

In addition, the common disadvantages of these traditional Chinese medicine preparations are that the prescription has too many medicinal flavors, the mechanism of action and active ingredients are not clear, the controllability of the production process is poor, the quality stability is low, and it is inconvenient to take more.

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