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Antidepressant and anxiolytic use of Qing'e prescription extract

An extract, anti-anxiety technology, applied in the field of anti-depression and anti-anxiety use of Qing'e Fang extract

Active Publication Date: 2016-06-08
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention relates to the preparation of Qing'e Fang extract and its antidepressant and anti-anxiety effects and efficacy, and no related reports have been seen

Method used

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  • Antidepressant and anxiolytic use of Qing'e prescription extract
  • Antidepressant and anxiolytic use of Qing'e prescription extract
  • Antidepressant and anxiolytic use of Qing'e prescription extract

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0078] Experimental example 1 The improving effect of the rat olfactory bulb damage model caused by Qing'e pills of the present invention

[0079] (1) Experimental drugs and instruments

[0080] Drug: fluoxetine hydrochloride (also known as Prozac), batch number 2076A, produced by Fatheon France. Venlafaxine, lot number 1308025, manufactured by Pfizer Iretand Pharmaceuticals. Isoflurane, r-aminobutyric acid (GABA), glutamic acid (Glu), 5-hydroxytryptamine (5-HT) 5-HT, epinephrine (Epi), dopamine (DA) DA, norepinephrine (NE ) NE, 5-hydroxyindoleacetic acid (5-HIAA), 3,4-dihydroxybenzylamine (internal standard) are all products of Sigma Company.

[0081] Instrument: "Doctor Mouse" animal behavior analysis: elevated plus maze (RD1108-EPM-M), forced swimming test analysis system model (RD1119-FST-M), tail suspension test analysis system model (RD1118-TST-M), Open field test analysis system (RD1112-OFT-M). Anesthesia machine: (SNMSSN5374.UK), electric bone drill (BJ1102SAO), "D...

Embodiment 1

[0153] Embodiment 1: Qing'e side extract 1

[0154] Eucommia (stir-fried with salt) 480 grams, psoralen (stir-fried with salt) 240 grams, walnut kernels (stir-fried) 150 grams, garlic 120 grams

[0155] The above medicinal materials were taken according to the above proportions, 8 times the volume of 75% ethanol was refluxed and extracted 3 times, each time for 1.5 hours, and the solvent was recovered under reduced pressure to obtain Qing'efang extract 1.

Embodiment 2

[0156] Embodiment 2: Qing'e side extract 2

[0157] Eucommia (stir-fried with salt) 480 grams, psoralen (stir-fried with salt) 240 grams, walnut kernels (stir-fried) 150 grams, garlic 120 grams

[0158] Take 480g of eucommia decoction pieces fried with salt according to the above ratio, and use 8 times the volume of petroleum ether, ethyl acetate, and ethanol in turn to extract 3 times under reflux, each extraction for 1.5 hours, mix the above extracts, and recover the solvent under reduced pressure to obtain the eucommia extract thing;

[0159] Stir-fry psoralen 240g with salt, sequentially use 8 times the volume of petroleum ether, ethyl acetate, and ethanol, and extract each under reflux for 3 times, each time for 1.5 hours, mix the above extracts, recover the solvent under reduced pressure, and obtain psoralen extract thing;

[0160] Take 150 g of fried peach kernels, sequentially use 8 times the volume of petroleum ether, ethyl acetate, and ethanol, and extract each und...

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Abstract

The invention discloses a use of a Qing'e prescription extract in preparation of an antidepressant and anxiolytic composition. With oral administration of the Qing'e prescription extract, the experimental animal mine field movement total distance can be increased, the tail suspension immobility time is reduced, the elevated plus maze open-arm time is increased, the forced swimming immobility time is reduced, and relatively good antidepressant and anxiolytic effects are shown. The Qing'e prescription extract can increase the contents of hippocampal area 5-hydroxytryptamine (5-HT), norepinephrine (NE) and gamma-aminobutyric acid (gamma-GABA), and reduces the content of glutamate (Glu). On one hand, the gamma-GABA increasing role and the Glu reduction role of the Qing'e prescription extract indicate that the Qing'e prescription extract has a role in adjusting metabolism of central nervous system neurotransmitters Glu and gamma-GABA, reduces the Glu / gamma-GABA ratio, reduces transmission of GABAergic neurotransmitters, regulates the reactivity of a catecholamine acceptor, thereby playing antidepressant and anxiolytic roles. On the other hand, the Qing'e prescription extract increases the central nervous system 5-HT level and plays the antidepressant and anxiolytic roles by inhibiting the activity of monoamine oxidase.

Description

technical field [0001] The invention relates to a new application of Qing'e Fang extract in preparing products and / or medicines for treating or alleviating depression and anxiety. technical background [0002] The current incidence of depression in China is about 4%. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world, and it is estimated that by 2020, it may become the second largest disease after coronary heart disease. Depression not only brings mental loss to patients, but also causes heavy economic burden to patients. The total economic burden caused by depression in China reaches 62.2 billion yuan, and the annual economic loss caused by depression in the United States reaches 43.7 billion US dollars. A joint study by the World Health Organization, the World Bank and Harvard University shows that depression has become the second largest disease burden in China. [0003] Depression is associated w...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P25/24A61P25/22
Inventor 王峥涛胡芳弟张紫佳吴晓俊陈文霞
Owner SHANGHAI UNIV OF T C M
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