Pharmaceutical composition of chlorambucil and medical application of pharmaceutical composition to anti-depression

A technology of chlorambucil and its composition, which is applied in the field of biomedicine, can solve the problems that there are no related reports on chlorambucil and its pharmaceutical composition, and achieve outstanding substantive features, improved antidepressant effect, Significantly improved effect

Inactive Publication Date: 2016-10-12
赵吉永
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between

Method used

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  • Pharmaceutical composition of chlorambucil and medical application of pharmaceutical composition to anti-depression
  • Pharmaceutical composition of chlorambucil and medical application of pharmaceutical composition to anti-depression
  • Pharmaceutical composition of chlorambucil and medical application of pharmaceutical composition to anti-depression

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0017] Example 1: Compound (Ⅰ) isolation preparation and structure confirmation

[0018] Reagent sources: ethanol, petroleum ether, ethyl acetate, n-butanol, dichloromethane are analytically pure, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd., methanol, analytically pure, purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0019] Separation method: (a) Crush the dried roots (2kg) of Radix Pseudostellariae, extract with 80% ethanol under hot reflux (15L×3 times), combine the extracts, concentrate until there is no alcohol smell (3L), and use petroleum ether (3L). ×3 times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) In step (a), the n-butanol extract is removed with D101 type macroporous resin, first eluting 8 column volumes with 10% ethanol, then eluting 10 column volumes with 70% ethanol, collect 70% eluate, and reduce Press and concent...

Example Embodiment

[0022] Example 2: Antidepressant effect

[0023] 1. Materials and methods

[0024] 1.1 Animals

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Abstract

The invention discloses a pharmaceutical composition of chlorambucil and medical application of the pharmaceutical composition to anti-depression. The pharmaceutical composition of chlorambucil contains chlorambucil and a natural product compound (I) which is separated out of dry tuberous roots of radix pseudostellariae and is novel in structure, and the chlorambucil and the natural product have a certain anti-depression effect when acting separately; the anti-depression effect is further improved when the chlorambucil and the natural product jointly act, and the pharmaceutical composition can be developed into anti-depression medicine. Compared with the prior art, the pharmaceutical composition of chlorambucil and the medical application of the pharmaceutical composition to anti-depression have outstanding substantive features and remarkable progresses.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of chlorambucil, in particular to a pharmaceutical composition of chlorambucil and its antidepressant medical application. Background technique [0002] Chlorambucil is a derivative of nitrogen mustard, its effect is similar to that of cyclophosphamide, and it has inhibitory effect on a variety of tumors. It is clinically used for chronic lymphocytic leukemia, lymphosarcoma, Hokinger's disease, ovarian cancer, breast cancer, and villous epithelioma , multiple myeloma, etc. Chlorambucil has a good effect on Cheeter's syndrome (genital ulcers, aphthous ulcers and uveitis syndrome), lupus erythematosus, and Wegener's granulomatosis; it is used for the treatment of vascular diseases complicated by rheumatoid arthritis Inflammation and autoimmune hemolytic anemia with cold lectin have good effect; patients with corticosteroid-dependent nephrotic syndrome can get complete rem...

Claims

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Application Information

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IPC IPC(8): A61K31/336A61K31/196C07D303/32C07D301/32A61P25/24
CPCA61K31/196A61K31/336C07D301/32C07D303/32A61K2300/00A61P25/24
Inventor 不公告发明人
Owner 赵吉永
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