Anti-depression pharmaceutical composition

A technology of antidepressant and composition, applied in the field of preparation of the traditional Chinese medicine composition, to achieve the effect of clear drug effect

Active Publication Date: 2015-03-25
闻喜复康心脑专科医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For many years, tricyclic antidepressants and monoamine oxidase inhibitors have been widely used in the treatment of depression, but due to relatively serious adverse reactions, such as tricyclic antidepressants can block a variety of transmitter receptors, and oral Many side effects such as dryness, constipation, dysuria, blurred vision, memory impairment and tachycardia, etc. MAO inhibitors will interact with many drugs and specific foods, causing severe adverse reactions such as hypertensive crisis, acute yellow liver atrophy, etc. Foreign countries have begun to pay attention to the development of ideal new antidepressant drugs from traditional Chinese medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 600g of Schisandra chinensis, heat and reflux extraction with 8 times the amount of 90% ethanol, extract three times, each time for 1 hour, filter, combine the filtrates, recover ethanol under reduced pressure and concentrate into a thick paste. Weigh 360g Nardinus, extract the volatile oil by steam distillation, clathrate with β-cyclodextrin, and collect the distilled aqueous solution in another device. Combine the medicinal residues of Gansong with 600g Bupleuri and 360g licorice, add water to decoct three times, each time for 1 hour, filter, combine the filtrate, combine with the distilled aqueous solution, concentrate to a thick paste, and combine with the thick paste of Schisandra chinensis above, Dry, crush into fine powder, add volatile oil clathrate powder and mix, then add appropriate amount of soluble starch, mix well, dry to make granules.

Embodiment 2

[0022] Weigh 300g of Schisandra chinensis, heat and reflux extraction with 8 times the amount of 90% ethanol, extract three times, each time for 1 hour, filter, combine the filtrates, recover ethanol under reduced pressure and concentrate into a thick paste. Weigh 180g Nardinosa, extract the volatile oil by steam distillation, clathrate with β-cyclodextrin, and collect the distilled aqueous solution in another device. Combine the dregs of Gansong with 300g Bupleuri and 180g licorice, add water and decoct three times for 1 hour each time, filter, combine the filtrate, combine with the distilled aqueous solution, concentrate to a thick paste, and combine with the thick paste of Schisandra chinensis above, Drying, crushing into fine powder, adding volatile oil clathrate powder and mixing, then adding appropriate amount of soluble starch, mixing, drying to make granules, and packing into capsules to obtain capsules.

Embodiment 3

[0024] 1 material

[0025] 1.1 Experimental animals

[0026] 516 healthy Kunming mice, half male and half female, weighing 20±2g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2012-0001.

[0027] 1.2 Reagents and medicines

[0028] 1.2.1 Pharmaceutical composition of the present invention

[0029] The granules prepared in Example 1.

[0030] 1.2.2 Schisandra extract

[0031] Schisandra chinensis was extracted three times with 90% ethanol under reflux, each time for 1 hour, filtered, combined filtrate, recovered ethanol under reduced pressure and concentrated to a thick paste, dried. Every 0.18g of schisandra alcohol extract is equivalent to 1g of schisandra medicinal material.

[0032] 1.2.3 Nardinus extract

[0033] Steam distilled pine nuts to extract the volatile oil, grind and clathrate with 6 times the amount of β-cyclodextrin; add 10 times the amount of water to the residue and decoct three times, 1 ...

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Abstract

The invention provides an anti-depression pharmaceutical composition. The anti-depression pharmaceutical composition is a preparation prepared from the following crude drugs in parts by weight: 3-10 parts of radix bupleuri, 3-9 parts of rhizoma nardostachyos, 6-12 parts of schisandra chinensis, 2-10 parts of radix glycyrrhizae. The pharmaceutical composition prepared in the invention has an anti-depression effect, can be used for treating depression, and is especially specific in pesticide effect of treating liver-qi stagnation type and liver-stagnation spleen-stagnation type depression. A new drug use selection is provided for the clinical treatment.

Description

technical field [0001] The invention relates to an antidepressant pharmaceutical composition, and also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Depression is an affective disorder whose main symptoms are persistent low mood and cognitive dysfunction, including restlessness, anhedonia, sleep disturbance, guilt, and repeated suicidal thoughts. , social and other factors. With the continuous development of society, the pace of modern life continues to accelerate, the pressure and competition faced by people in daily life and work are increasing day by day, the occurrence of depression is gradually increasing, and it has become a mental disease that seriously endangers human physical and mental health. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world, and it is estimated that by 2020, it will become the second most harmful disease afte...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/57A61P25/24
CPCA61K9/1652A61K36/185A61K36/233A61K36/484A61K36/57A61K36/79A61K2236/333A61K2236/37A61K2300/00
Inventor 裴妙荣李慧峰
Owner 闻喜复康心脑专科医院
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