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Antiallergic nasal medicine composition with high moisture retention and preparation methods and applications thereof

A technology with high moisture retention and composition, which is applied in the field of medicine, can solve the problems of organic lesions that can only relieve symptoms, inconvenience for patients, and rapid nasal dryness, so as to overcome the problem of bioavailability, reduce gastrointestinal excretion, The effect of lowering the dosage

Inactive Publication Date: 2019-01-29
XIAN LIBANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The basic method is to use appropriate tools to thoroughly rinse the nasal cavity, remove allergens, germs, inflammatory secretions and other dirty things in the nasal cavity, eliminate the basis for the continued development of inflammation, and eliminate the edema and swelling of the nasal mucosa. Restore the normal physiological function of the nasal cavity, but only relieve symptoms for organic lesions
The main components of nasal washes commonly used in clinical practice are physiological sodium chloride or isotonic sea salt water. However, the biggest problem with this type of device is that the nasal cavity dries quickly after nasal washes are rinsed, and the moisture retention is very short. times, the patient is very inconvenient

Method used

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  • Antiallergic nasal medicine composition with high moisture retention and preparation methods and applications thereof
  • Antiallergic nasal medicine composition with high moisture retention and preparation methods and applications thereof
  • Antiallergic nasal medicine composition with high moisture retention and preparation methods and applications thereof

Examples

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Effect test

preparation example 1

[0115] The basic composition of the sea saline solution for nasal use provided by the invention (excluding main ingredients), as shown in Table 1.

[0116] Table 1 Basic composition of nasal pharmaceutical composition (aqueous solution)

[0117]

[0118] The preparation method of the aqueous solution is as follows: taking the prescribed amount of sodium hyaluronate and dissolving it in purified water, fully stirring until completely dissolved, then adding the prescribed amount of glycerin, sea salt and main ingredients in sequence and stirring evenly to obtain the product.

preparation example 2

[0120] The basic composition of the nasal pharmaceutical composition (aqueous solution) provided by the present invention is shown in Table 2.

[0121] Table 2 Basic composition of nasal pharmaceutical composition (aqueous solution)

[0122]

[0123] The main drug is selected from levocetirizine hydrochloride, azastatine maleate, stastatine hydrochloride, bilastine fumarate, clemastine fumarate, epinastine hydrochloride, moxifloxacin hydrochloride one or more of.

[0124] The preparation method of the aqueous solution is as follows: take the prescribed amount of sodium hyaluronate and dissolve it in purified water, fully stir until it is completely dissolved, then add the prescribed amount of glycerin, sea salt and the main ingredient and stir evenly, and adjust the appropriate amount of pH regulator to pH 6.0 It can be obtained within the range of ~7.0.

preparation example 3

[0126] The basic composition of the nasal pharmaceutical composition (beta-cyclodextrin inclusion solution) provided by the present invention is shown in Table 3.

[0127] Table 3 Basic composition of nasal pharmaceutical composition (β-cyclodextrin inclusion solution)

[0128]

[0129] Note: The main drug is loratadine.

[0130] The preparation method of the β-cyclodextrin inclusion solution is as follows: weighing the raw materials of the prescription amount and adding an appropriate amount of ethanol to dissolve to obtain the ethanol solution. Dissolve hyaluronate in purified water and stir until it is completely dissolved. Add the prescribed amount of glycerin and sea salt to the solution, stir evenly, then add the prescribed amount of β-cyclodextrin, and heat to 40°C to obtain an aqueous solution. Slowly add the ethanol solution to the mixture, stirring while adding, the stirring speed is 50rpm. After the addition, stir for 20 minutes, let it stand overnight, and fil...

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Abstract

The invention provides an antiallergic nasal medicine composition with high moisture retention and preparation methods and applications thereof. The composition has high moisture retention and no irritation to a nasal mucosa. The composition comprises levocetirizine, azatadine, loratadine, ebastine, setastine, bilastine, clemastine, mizolastine, epinastine and moxifloxacin which are antiallergic medicine as main medicine, wherein the main medicine can be salts or free alkalis, sea salt as an osmotic pressure regulator, and a mixture of sodium hyaluronate and glycerin of different molecular weights as a moisturizing excipient. Plant essential oil can be contained in the composition. Preparations can be an aqueous solution, a cyclodextrin-coated suspension or a nanosuspension. Dosage forms include spray, aerosol and nose drops. Main indications include nasal dryness, runny nose, nasal itching, nasal obstruction and the like due to allergic rhinitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a highly moisturizing anti-allergic nasal pharmaceutical composition, a preparation method and application thereof. Background technique [0002] Allergic rhinitis is a kind of allergic inflammation, also known as perennial allergic rhinitis, vasomotor rhinitis. The main clinical manifestations are paroxysmal nasal itching, dry nose, sneezing, a large amount of watery nasal discharge during acute attack, less and thicker when relieved, and mucopurulent, intermittent or persistent, unilateral or bilateral nasal congestion in concurrent infection , hyposmia or disappearance, headache, tinnitus, tearing, hoarseness and chronic cough. Systemic symptoms include headache, loss of appetite, easy fatigue, memory loss and insomnia. [0003] The clinical symptoms of rhinitis are different, and they are extremely harmful. When the physiological function of the nasal cavity is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K47/36A61K47/10A61K47/26A61P11/02A61P37/08A61K36/534A61K36/53A61K36/752
CPCA61K45/00A61K47/10A61K47/26A61K47/36A61K9/0043A61K36/53A61K36/534A61K36/752A61K2300/00
Inventor 李选民鹿静卢伍党王九成
Owner XIAN LIBANG PHARMA TECH
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