Compound traditional Chinese medicine for treating depression
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A technology of depression and traditional Chinese medicine, applied in the field of medicine, can solve problems such as easy recurrence, high drug price, and large toxic and side effects
Active Publication Date: 2012-05-23
HUNAN UNIV OF CHINESE MEDICINE
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[0003] For the treatment of depression, Western medicine currently uses 5-hydroxytryptamine reuptake inhibitors, monoamine oxidase inhibitors, phenylpyrazine derivatives, 5-hydroxytryptamine-norepinephrine reuptake inhibitors, aminoketones,
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Embodiment 1
[0014] The granule dosage form of embodiment 1 pharmaceutical composition of the present invention
[0015] Using the conventional method of preparing granules, take 2 parts of lily, 2 parts of jujube seed, 1 part of turmeric, 1.5 parts of Hypericum perforatum, 1 part of ginseng, and 1.5 parts of perilla, soak them in water for 0.5 hours and then extract them twice, adding 10 parts of water respectively. times, 8 times, the first extraction for 2 hours, the second extraction for 1.5 hours, filtering, combining the filtrates, concentrating, drying, pulverizing, adding an appropriate amount of excipients, mixing, granulating, sieving, and drying to obtain a granular dosage form Pharmaceutical composition preparation.
Embodiment 2
[0016] Tablet dosage form of embodiment 2 pharmaceutical composition of the present invention
[0017] Using the conventional method for preparing tablets, take 0.8 parts of Lily, 1 part of Jujube Seed, 0.8 part of Turmeric, 0.3 part of Hypericum perforatum, 0.8 part of Perilla, and 1 part of Bupleurum, soak them in 70% ethanol for 0.5 hours, and then extract twice. The amount of water added is 6 times and 4 times respectively, the first extraction is 2 hours, the second extraction is 1 hour, filtered, the filtrate is combined, concentrated, dried, crushed, and an appropriate amount of auxiliary materials is added, mixed, granulated, sieved, and dried. The prepared granules are further compressed and dried to obtain a pharmaceutical composition preparation in the form of a tablet.
Embodiment 3
[0018] The capsule dosage form of embodiment 3 pharmaceutical compositions of the present invention
[0019] Using the conventional method for preparing capsules, take 1 part of lily flower, 1.5 parts of jujube seed, 0.9 part of turmeric, 1 part of Hypericum perforatum, 0.8 part of ginseng, 1 part of perilla, and 0.5 part of Bupleurum bupleurum, add 60% ethanol to soak for 0.5 hours Extract 2 times, add water 7 times and 5 times respectively, extract for 2 hours for the first time, extract for 1 hour for the second time, filter, combine the filtrate, concentrate, dry and crush, add an appropriate amount of auxiliary materials, mix well, granulate, pass Sieve, dry, and pack the prepared granules into capsule shells to make capsules, that is, to obtain a pharmaceutical composition preparation in the form of capsules.
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Abstract
The invention discloses a Chinese medicinal composition for treating depression. The medicine adopts lilies, semen ziziphi apinosae, curcuma longa, hypericum perforatum L., perilla, ginseng, and radix bupleuri as raw materials, which are then separate and extracted by 0-75% ethanol so as to be prepared into certain preparation form. The above six drugs used together can soothe liver and relieve depression, reconcile and activate qi, tranquilize the mind and calm the nerves, and can be used for mild and moderate depression and patients belonging to stagnation of qi due to depression of liver, as well as heart-spleen deficiency. Pharmacodynamic research indicates that: the medicinal composition has substantial antagonistic effects on reserpine induced depression models, mouse akinesia and hypothermia, and can increase the spontaneous movements of tail suspension and forced swimming induced despair animal models, as well as the immobility time of tail suspension and swimming. Clinical research results show that a HAMD (Hamilton depression scale) used for evaluating depression severity and Chinese medicinal syndromes before and after treatment are taken as main curative effect indexes, which show that the Chinese medicinal composition in the invention has substantial curative effects. The composition provided in the invention can be prepared into medically acceptable oral preparations, such as tablets, capsules (soft capsules and hard capsules), granules, and other preparation forms. Clinical effects and pharmacodynamic research prove that the Chinese medicinal composition of the invention has the functions of liver soothing and depression relieving, mind tranquilizing as well as nerve calming, and is an effective medicine special for depression treatment.
Description
technical field [0001] The invention belongs to the technical field of medicine, and relates to a medicine for treating depression, in particular to a traditional Chinese medicine composition of lily flower, jujube seed, turmeric, hypericum perforatum, ginseng and perilla. Background technique [0002] Depression is a common emotional and mental disorder. With the acceleration of the pace of social life, depression has become a high-risk disease in today's society. According to the statistics of the World Health Organization in 2005, the prevalence of various depressions accounts for about 11% of the global population. According to the epidemiological survey in my country in 2003, there are at least 36 million depression patients in my country, of which only 5% of severe patients receive relevant treatment. Many patients with major depressive disorder commit suicide due to lack of regular treatment in time. According to the analysis of death data in 2003, at least 287,000 ...
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Application Information
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